Identification of cytochrome P450 enzymes in human colorectal metastases and the surrounding liver: a proteomic approach
Lane, C.S., Nisar, S., Griffiths, W.J., Fuller, B.J., Davidson, B.R., Hewes, J., Welham, K.J., Patterson, L.H.
Published in European journal of cancer (1990) (01.09.2004)
Published in European journal of cancer (1990) (01.09.2004)
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Journal Article
Colon Cancer―Specific Cytochrome P450 2W1 Converts Duocarmycin Analogues into Potent Tumor Cytotoxins
TRAVICA, Sandra, PORS, Klaus, LOADMAN, Paul M, SHNYDER, Steven D, JOHANSSON, Inger, ALANDAS, Mohammed N, SHELDRAKE, Helen M, MKRTCHIAN, Souren, PATTERSON, Laurence H, INGELMAN-SUNDBERG, Magnus
Published in Clinical cancer research (01.06.2013)
Published in Clinical cancer research (01.06.2013)
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Journal Article
Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity
Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H, Pors, Klaus
Published in Journal of medicinal chemistry (08.08.2013)
Published in Journal of medicinal chemistry (08.08.2013)
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Journal Article
The use of pharmacokinetic and pharmacodynamic end points to determine the dose of AQ4N, a novel hypoxic cell cytotoxin, given with fractionated radiotherapy in a phase I study
Steward, WP, Middleton, M, Benghiat, A, Loadman, PM, Hayward, C, Waller, S, Ford, S, Halbert, G, Patterson, LH, Talbot, D
Published in Annals of oncology (01.06.2007)
Published in Annals of oncology (01.06.2007)
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Journal Article
Minor structural modifications to alchemix influence mechanism of action and pharmacological activity
Abdallah, Qasem M.A., Phillips, Roger M., Johansson, Fredrik, Helleday, Thomas, Cosentino, Laura, Abdel-Rahman, Hamdy, Etzad, Jasarat, Wheelhouse, Richard T., Kiakos, Konstantinos, Bingham, John P., Hartley, John A., Patterson, Laurence H., Pors, Klaus
Published in Biochemical pharmacology (01.06.2012)
Published in Biochemical pharmacology (01.06.2012)
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Journal Article
Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor
Pors, K, Paniwnyk, Z, Ruparelia, KC, Teesdale-Spittle, PH, Hartley, JA, Kelland, LR, Patterson, LH
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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Journal Article
Progress in drugging CYP1A1, 1B1 and CYP2W1 overexpressed in cancer
Pors, K, Le Morvan, V, Travica, S, Shnyder, SD, Sutherland, M, Sheldrake, HM, Searcey, M, Johansson, I, Mkrtchian, S, Loadman, PM, Robert, J, Ingelman-Sundberg, M, Patterson, LH
Published in EUROPEAN JOURNAL OF CANCER (2014)
Published in EUROPEAN JOURNAL OF CANCER (2014)
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Conference Proceeding
CYP2W1 as a novel therapeutic target in colon cancer
Pors, K, Loadman, PM, Travica, S, Shnyder, SD, Sutherland, M, Sheldrake, H, Searcey, M, Johansson, I, Mkrtchian, S, Ingelman-Sundberg, M, Patterson, LH
Published in CANCER RESEARCH (2014)
Published in CANCER RESEARCH (2014)
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Conference Proceeding
Development of Nonsymmetrical 1,4-Disubstituted Anthraquinones That Are Potently Active against Cisplatin-Resistant Ovarian Cancer Cells
Pors, Klaus, Plumb, Jane A, Brown, Robert, Teesdale-Spittle, Paul, Searcey, Mark, Smith, Paul J, Patterson, Laurence H
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Journal Article
Design and synthesis of a DNA-crosslinking azinomycin analogue
Casely-Hayford, MA, Pors, K, James, CH, Patterson, LH, Hartley, JA, Searcey, M
Published in Organic & biomolecular chemistry (07.10.2005)
Published in Organic & biomolecular chemistry (07.10.2005)
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Journal Article
Bioreductive GDEPT using cytochrome P450 3A4 in combination with AQ4N
McCarthy, Helen O, Yakkundi, Anita, McErlane, Verna, Hughes, Ciara M, Keilty, Gillian, Murray, Margaret, Patterson, Laurence H, Hirst, David G, McKeown, Stephanie R, Robson, Tracy
Published in Cancer gene therapy (01.01.2003)
Published in Cancer gene therapy (01.01.2003)
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Journal Article
Truncated azinomycin analogues intercalate into DNA
Casely-Hayford, Maxwell A., Pors, Klaus, Patterson, Laurence H., Gerner, Clive, Neidle, Stephen, Searcey, Mark
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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Journal Article