A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers
Smith, Patrick F., Krishnarajah, Janakan, Nunn, Philip A., Hill, Ron J., Karr, Dane, Tam, D., Masjedizadeh, Mohammad, Funk, Jens O., Gourlay, Steve G.
Published in British journal of clinical pharmacology (01.11.2017)
Published in British journal of clinical pharmacology (01.11.2017)
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Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results
Oey, Abbie, McClure, Matthew, Symons, Julian A, Chanda, Sushmita, Fry, John, Smith, Patrick F, Luciani, Kathia, Fayon, Michael, Chokephaibulkit, Kulkanya, Uppala, Rattapon, Bernatoniene, Jolanta, Furuno, Kenji, Stanley, Thorsten, Huntjens, Dymphy, Witek, James
Published in PloS one (19.07.2023)
Published in PloS one (19.07.2023)
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Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial
Gane, Edward J, Dr, Roberts, Stuart K, MD, Stedman, Catherine AM, MD, Angus, Peter W, Prof, Ritchie, Brett, MD, Elston, Rob, PhD, Ipe, David, MS, Morcos, Peter N, PharmD, Baher, Linda, BS, Najera, Isabel, PhD, Chu, Tom, MD, Lopatin, Uri, MD, Berrey, M Michelle, MD, Bradford, William, MD, Laughlin, Mark, MD, Shulman, Nancy S, MD, Smith, Patrick F, PharmD
Published in The Lancet (British edition) (30.10.2010)
Published in The Lancet (British edition) (30.10.2010)
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Journal Article
An evaluation of a supratherapeutic dose of inclisiran on cardiac repolarization in healthy volunteers: A phase I, randomized study
Kallend, David, Mason, Jay, Smith, Patrick F., Koren, Michael J., Stoekenbroek, Robert, He, YanLing, Wijngaard, Peter
Published in Clinical and translational science (01.11.2022)
Published in Clinical and translational science (01.11.2022)
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Journal Article
Optimizing COVID‐19 Candidate Therapeutics: Thinking Without Borders
Rayner, Craig R., Smith, Patrick F., Hershberger, Kevin, Wesche, David
Published in Clinical and Translational Science (01.09.2020)
Published in Clinical and Translational Science (01.09.2020)
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Journal Article
Web Resource
Phase 1 clinical trial evaluating safety, exposure and pharmacodynamics of BTK inhibitor tolebrutinib (PRN2246, SAR442168)
Owens, Timothy D., Smith, Patrick F., Redfern, Andrew, Xing, Yan, Shu, Jin, Karr, Dane E., Hartmann, Sonja, Francesco, Michelle R., Langrish, Claire L., Nunn, Philip A., Gourlay, Steven G.
Published in Clinical and translational science (01.02.2022)
Published in Clinical and translational science (01.02.2022)
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Journal Article
Rilzabrutinib, a reversible covalent Bruton's tyrosine kinase inhibitor: Absorption, metabolism, excretion, and absolute bioavailability in healthy participants
Ucpinar, Sibel, Smith, Patrick F., Long, Li, Li, Fujun, Yan, Hui, Wadhwa, Jyoti, Chu, Katherine A., Shu, Jin, Nunn, Philip, Li, Mengyao
Published in Clinical and translational science (01.07.2023)
Published in Clinical and translational science (01.07.2023)
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Journal Article
Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection
Smith, Patrick F, Ogundele, Abayomi, Forrest, Alan, Wilton, John, Salzwedel, Karl, Doto, Judy, Allaway, Graham P, Martin, David E
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
Published in Antimicrobial Agents and Chemotherapy (01.10.2007)
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A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects
Ucpinar, Sibel, Darpo, Borje, Neale, Ann, Nunn, Philip, Shu, Jin, Chu, Katherine A., Kavanagh, Marianne, Xue, Hongqi, Phiasivongsa, Pasit, Thomas, Dolca, Smith, Patrick F.
Published in Clinical and translational science (01.06.2022)
Published in Clinical and translational science (01.06.2022)
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Journal Article
Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks
Wollacott, Andrew M., Boni, Maciej F., Szretter, Kristy J., Sloan, Susan E., Yousofshahi, Mona, Viswanathan, Karthik, Bedard, Sylvain, Hay, Catherine A., Smith, Patrick F., Shriver, Zachary, Trevejo, Jose M.
Published in EBioMedicine (01.03.2016)
Published in EBioMedicine (01.03.2016)
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Journal Article
Characterization of the Transmembrane Transport and Absolute Bioavailability of the HCV Protease Inhibitor Danoprevir
Brennan, Barbara J., Poirier, Agnès, Moreira, Sebastian, Morcos, Peter N., Goelzer, Petra, Portmann, Renée, Asthappan, Jiney, Funk, Christoph, Smith, Patrick F.
Published in Clinical pharmacokinetics (01.05.2015)
Published in Clinical pharmacokinetics (01.05.2015)
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Journal Article
Population Pharmacokinetics of Oseltamivir: Pediatrics through Geriatrics
KAMAL, Mohamed A, VAN WART, Scott A, RAYNER, Craig R, SUBRAMONEY, Vishak, REYNOLDS, Daniel K, BULIK, Catharine C, SMITH, Patrick F, BHAVNANI, Sujata M, AMBROSE, Paul G, FORREST, Alan
Published in Antimicrobial Agents and Chemotherapy (01.08.2013)
Published in Antimicrobial Agents and Chemotherapy (01.08.2013)
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Journal Article
Dosing will be a key success factor in repurposing antivirals for COVID‐19
Smith, Patrick F., Dodds, Michael, Bentley, Darren, Yeo, Karen, Rayner, Craig
Published in British journal of clinical pharmacology (01.09.2021)
Published in British journal of clinical pharmacology (01.09.2021)
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Journal Article
Attenuated Vancomycin Bactericidal Activity against Staphylococcus aureus hemB Mutants Expressing the Small-Colony-Variant Phenotype
TSUJI, Brian T, VON EIFF, Christof, KELCHLIN, Pamela A, FORREST, Alan, SMITH, Patrick F
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
Published in Antimicrobial Agents and Chemotherapy (01.04.2008)
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Journal Article
Pharmacokinetics and Pharmacodynamics of Setrobuvir, an Orally Administered Hepatitis C Virus Non-Nucleoside Analogue Inhibitor
Mallalieu, Navita L., PhD, Rahimy, Mohamad H., PhD, Crowley, Constance A., BSc, Appleman, James R., PhD, Smith, Patrick F., PharmD, Freddo, James L., MD
Published in Clinical therapeutics (01.12.2014)
Published in Clinical therapeutics (01.12.2014)
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Journal Article
Pharmacokinetics of a Three-Way Drug Interaction Between Danoprevir, Ritonavir and the Organic Anion Transporting Polypeptide (OATP) Inhibitor Ciclosporin
Brennan, Barbara J., Moreira, Sebastian A., Morcos, Peter N., Navarro, Mercidita T., Asthappan, Jiney, Goelzer, Petra, Weigl, Paul, Smith, Patrick F.
Published in Clinical pharmacokinetics (01.09.2013)
Published in Clinical pharmacokinetics (01.09.2013)
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Journal Article
Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection
SCHAEFER, Caralee J, KOSSEN, Karl, LIM, Sharlene R, LIN, Jiing-Huey, LIN PAN, BRADFORD, Williamson, SMITH, Patrick F, SEIWERT, Scott D
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
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