Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles
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Published in Cell (19.06.2014)
Published in Cell (19.06.2014)
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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d
Zhang, Cheng, Konermann, Silvana, Brideau, Nicholas J., Lotfy, Peter, Wu, Xuebing, Novick, Scott J., Strutzenberg, Timothy, Griffin, Patrick R., Hsu, Patrick D., Lyumkis, Dmitry
Published in Cell (20.09.2018)
Published in Cell (20.09.2018)
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Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
Zhou, X. Edward, He, Yuanzheng, de Waal, Parker W., Gao, Xiang, Kang, Yanyong, Van Eps, Ned, Yin, Yanting, Pal, Kuntal, Goswami, Devrishi, White, Thomas A., Barty, Anton, Latorraca, Naomi R., Chapman, Henry N., Hubbell, Wayne L., Dror, Ron O., Stevens, Raymond C., Cherezov, Vadim, Gurevich, Vsevolod V., Griffin, Patrick R., Ernst, Oliver P., Melcher, Karsten, Xu, H. Eric
Published in Cell (27.07.2017)
Published in Cell (27.07.2017)
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Structural and mechanistic bases for a potent HIV-1 capsid inhibitor
Bester, Stephanie M, Wei, Guochao, Zhao, Haiyan, Adu-Ampratwum, Daniel, Iqbal, Naseer, Courouble, Valentine V, Francis, Ashwanth C, Annamalai, Arun S, Singh, Parmit K, Shkriabai, Nikoloz, Van Blerkom, Peter, Morrison, James, Poeschla, Eric M, Engelman, Alan N, Melikyan, Gregory B, Griffin, Patrick R, Fuchs, James R, Asturias, Francisco J, Kvaratskhelia, Mamuka
Published in Science (American Association for the Advancement of Science) (16.10.2020)
Published in Science (American Association for the Advancement of Science) (16.10.2020)
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TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis
Ye, Li, Kleiner, Sandra, Wu, Jun, Sah, Rajan, Gupta, Rana K, Banks, Alexander S, Cohen, Paul, Khandekar, Melin J, Boström, Pontus, Mepani, Rina J, Laznik, Dina, Kamenecka, Theodore M, Song, Xinyi, Liedtke, Wolfgang, Mootha, Vamsi K, Puigserver, Pere, Griffin, Patrick R, Clapham, David E, Spiegelman, Bruce M
Published in Cell (28.09.2012)
Published in Cell (28.09.2012)
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The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
Long, Jonathan Z., Svensson, Katrin J., Bateman, Leslie A., Lin, Hua, Kamenecka, Theodore, Lokurkar, Isha A., Lou, Jesse, Rao, Rajesh R., Chang, Mi Ra, Jedrychowski, Mark P., Paulo, Joao A., Gygi, Steven P., Griffin, Patrick R., Nomura, Daniel K., Spiegelman, Bruce M.
Published in Cell (14.07.2016)
Published in Cell (14.07.2016)
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SPA70 is a potent antagonist of human pregnane X receptor
Lin, Wenwei, Wang, Yue-Ming, Chai, Sergio C., Lv, Lili, Zheng, Jie, Wu, Jing, Zhang, Qijun, Wang, Yong-Dong, Griffin, Patrick R., Chen, Taosheng
Published in Nature communications (29.09.2017)
Published in Nature communications (29.09.2017)
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Hydrogen–Deuterium Exchange Epitope Mapping of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase
O’Leary, Timothy R., Balasubramaniam, Deepa, Hughes, Kristin, Foster, Denisa, Boyles, Jeffrey, Coleman, Kristina, Griffin, Patrick R.
Published in Analytical chemistry (Washington) (11.07.2023)
Published in Analytical chemistry (Washington) (11.07.2023)
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A molecular switch regulating transcriptional repression and activation of PPARγ
Shang, Jinsai, Mosure, Sarah A., Zheng, Jie, Brust, Richard, Bass, Jared, Nichols, Ashley, Solt, Laura A., Griffin, Patrick R., Kojetin, Douglas J.
Published in Nature communications (19.02.2020)
Published in Nature communications (19.02.2020)
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Structure of the full-length glucagon class B G-protein-coupled receptor
Zhang, Haonan, Qiao, Anna, Yang, Dehua, Yang, Linlin, Dai, Antao, de Graaf, Chris, Reedtz-Runge, Steffen, Dharmarajan, Venkatasubramanian, Zhang, Hui, Han, Gye Won, Grant, Thomas D., Sierra, Raymond G., Weierstall, Uwe, Nelson, Garrett, Liu, Wei, Wu, Yanhong, Ma, Limin, Cai, Xiaoqing, Lin, Guangyao, Wu, Xiaoai, Geng, Zhi, Dong, Yuhui, Song, Gaojie, Griffin, Patrick R., Lau, Jesper, Cherezov, Vadim, Yang, Huaiyu, Hanson, Michael A., Stevens, Raymond C., Zhao, Qiang, Jiang, Hualiang, Wang, Ming-Wei, Wu, Beili
Published in Nature (London) (08.06.2017)
Published in Nature (London) (08.06.2017)
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One-step construction of circularized nanodiscs using SpyCatcher-SpyTag
Zhang, Shanwen, Ren, Qian, Novick, Scott J., Strutzenberg, Timothy S., Griffin, Patrick R., Bao, Huan
Published in Nature communications (14.09.2021)
Published in Nature communications (14.09.2021)
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CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase
He, Weiwei, Bai, Ge, Zhou, Huihao, Wei, Na, White, Nicholas M., Lauer, Janelle, Liu, Huaqing, Shi, Yi, Dumitru, Calin Dan, Lettieri, Karen, Shubayev, Veronica, Jordanova, Albena, Guergueltcheva, Velina, Griffin, Patrick R., Burgess, Robert W., Pfaff, Samuel L., Yang, Xiang-Lei
Published in Nature (London) (29.10.2015)
Published in Nature (London) (29.10.2015)
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Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases
Soon, Fen-Fen, Ng, Ley-Moy, Zhou, X. Edward, West, Graham M., Kovach, Amanda, Tan, M. H. Eileen, Suino-Powell, Kelly M., He, Yuanzheng, Xu, Yong, Chalmers, Michael J., Brunzelle, Joseph S., Zhang, Huiming, Yang, Huaiyu, Jiang, Hualiang, Li, Jun, Yong, Eu-Leong, Cutler, Sean, Zhu, Jian-Kang, Griffin, Patrick R., Melcher, Karsten, Xu, H. Eric
Published in Science (American Association for the Advancement of Science) (06.01.2012)
Published in Science (American Association for the Advancement of Science) (06.01.2012)
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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation
Shin, Mia, Watson, Edmond R., Song, Albert S., Mindrebo, Jeffrey T., Novick, Scott J., Griffin, Patrick R., Wiseman, R. Luke, Lander, Gabriel C.
Published in Nature communications (28.05.2021)
Published in Nature communications (28.05.2021)
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Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6
Liu, Wallace H., Zheng, Jie, Feldman, Jessica L., Klein, Mark A., Kuznetsov, Vyacheslav I., Peterson, Craig L., Griffin, Patrick R., Denu, John M.
Published in Nature communications (16.10.2020)
Published in Nature communications (16.10.2020)
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Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation
Fanning, Sean W, Mayne, Christopher G, Dharmarajan, Venkatasubramanian, Carlson, Kathryn E, Martin, Teresa A, Novick, Scott J, Toy, Weiyi, Green, Bradley, Panchamukhi, Srinivas, Katzenellenbogen, Benita S, Tajkhorshid, Emad, Griffin, Patrick R, Shen, Yang, Chandarlapaty, Sarat, Katzenellenbogen, John A, Greene, Geoffrey L
Published in eLife (02.02.2016)
Published in eLife (02.02.2016)
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Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3)
Li, Kuohan, Zheng, Jie, Wirawan, Melissa, Trinh, Nguyen Mai, Fedorova, Olga, Griffin, Patrick R, Pyle, Anna M, Luo, Dahai
Published in Nucleic acids research (27.09.2021)
Published in Nucleic acids research (27.09.2021)
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Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Zhang, Xianjun, Zhao, Fei, Wu, Yiran, Yang, Jun, Han, Gye Won, Zhao, Suwen, Ishchenko, Andrii, Ye, Lintao, Lin, Xi, Ding, Kang, Dharmarajan, Venkatasubramanian, Griffin, Patrick R., Gati, Cornelius, Nelson, Garrett, Hunter, Mark S., Hanson, Michael A., Cherezov, Vadim, Stevens, Raymond C., Tan, Wenfu, Tao, Houchao, Xu, Fei
Published in Nature communications (17.05.2017)
Published in Nature communications (17.05.2017)
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The Therapeutic Potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPARγ, RORs, and Rev-erbs
Marciano, David P., Chang, Mi Ra, Corzo, Cesar A., Goswami, Devrishi, Lam, Vinh Q., Pascal, Bruce D., Griffin, Patrick R.
Published in Cell metabolism (04.02.2014)
Published in Cell metabolism (04.02.2014)
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Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3
Zhao, Li-Hua, Zhou, X Edward, Yi, Wei, Wu, Zhongshan, Liu, Yue, Kang, Yanyong, Hou, Li, de Waal, Parker W, Li, Suling, Jiang, Yi, Scaffidi, Adrian, Flematti, Gavin R, Smith, Steven M, Lam, Vinh Q, Griffin, Patrick R, Wang, Yonghong, Li, Jiayang, Melcher, Karsten, Xu, H Eric
Published in Cell research (01.11.2015)
Published in Cell research (01.11.2015)
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