Homology Modeling of G-Protein-Coupled Receptors and Implications in Drug Design
PATNY, Akshay, DESAI, Prashant V, AVERY, Mitchell A
Published in Current medicinal chemistry (01.06.2006)
Published in Current medicinal chemistry (01.06.2006)
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Discovery of Clinical Candidate 1‑{[(2S,3S,4S)‑3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin‑1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design
Lee, Katherine L, Ambler, Catherine M, Anderson, David R, Boscoe, Brian P, Bree, Andrea G, Brodfuehrer, Joanne I, Chang, Jeanne S, Choi, Chulho, Chung, Seungwon, Curran, Kevin J, Day, Jacqueline E, Dehnhardt, Christoph M, Dower, Ken, Drozda, Susan E, Frisbie, Richard K, Gavrin, Lori K, Goldberg, Joel A, Han, Seungil, Hegen, Martin, Hepworth, David, Hope, Heidi R, Kamtekar, Satwik, Kilty, Iain C, Lee, Arthur, Lin, Lih-Ling, Lovering, Frank E, Lowe, Michael D, Mathias, John P, Morgan, Heidi M, Murphy, Elizabeth A, Papaioannou, Nikolaos, Patny, Akshay, Pierce, Betsy S, Rao, Vikram R, Saiah, Eddine, Samardjiev, Ivan J, Samas, Brian M, Shen, Marina W. H, Shin, Julia H, Soutter, Holly H, Strohbach, Joseph W, Symanowicz, Peter T, Thomason, Jennifer R, Trzupek, John D, Vargas, Richard, Vincent, Fabien, Yan, Jiangli, Zapf, Christoph W, Wright, Stephen W
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Chrencik, Jill E., Patny, Akshay, Leung, Iris K., Korniski, Brian, Emmons, Thomas L., Hall, Troii, Weinberg, Robin A., Gormley, Jennifer A., Williams, Jennifer M., Day, Jacqueline E., Hirsch, Jeffrey L., Kiefer, James R., Leone, Joseph W., Fischer, H. David, Sommers, Cynthia D., Huang, Horng-Chih, Jacobsen, E.J., Tenbrink, Ruth E., Tomasselli, Alfredo G., Benson, Timothy E.
Published in Journal of molecular biology (16.07.2010)
Published in Journal of molecular biology (16.07.2010)
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Identification of Novel Parasitic Cysteine Protease Inhibitors Using Virtual Screening. 1. The ChemBridge Database
Desai, Prashant V, Patny, Akshay, Sabnis, Yogesh, Tekwani, Babu, Gut, Jiri, Rosenthal, Philip, Srivastava, Anuradha, Avery, Mitchell
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
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Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor
Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T, Altman, Michael D, Rush, Thomas S, Cornea, Anda, Conn, P. Michael
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
Published in Molecular endocrinology (Baltimore, Md.) (01.02.2009)
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Design, Synthesis, and Docking Studies of Novel Benzimidazoles for the Treatment of Metabolic Syndrome
Mizuno, Cassia S, Chittiboyina, Amar G, Shah, Falgun H, Patny, Akshay, Kurtz, Theodore W, Pershadsingh, Harrihar A, Speth, Robert C, Karamyan, Vardan T, Carvalho, Paulo B, Avery, Mitchell A
Published in Journal of medicinal chemistry (11.02.2010)
Published in Journal of medicinal chemistry (11.02.2010)
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Identification of Novel Parasitic Cysteine Protease Inhibitors by Use of Virtual Screening. 2. The Available Chemical Directory
Desai, Prashant V, Patny, Akshay, Gut, Jiri, Rosenthal, Philip J, Tekwani, Babu, Srivastava, Anuradha, Avery, Mitchell
Published in Journal of medicinal chemistry (09.03.2006)
Published in Journal of medicinal chemistry (09.03.2006)
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Ligand-supported homology modeling of the human angiotensin II type 1 (AT1) receptor: Insights into the molecular determinants of telmisartan binding
Patny, Akshay, Desai, Prashant V., Avery, Mitchell A.
Published in Proteins, structure, function, and bioinformatics (01.12.2006)
Published in Proteins, structure, function, and bioinformatics (01.12.2006)
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Design and Synthesis of the First Generation of Dithiolane Thiazolidinedione- and Phenylacetic Acid-Based PPARγ Agonists
Chittiboyina, Amar G, Venkatraman, Meenakshi S, Mizuno, Cassia S, Desai, Prashant V, Patny, Akshay, Benson, Stephen C, Ho, Christopher I, Kurtz, Theodore W, Pershadsingh, Harrihar A, Avery, Mitchell A
Published in Journal of medicinal chemistry (13.07.2006)
Published in Journal of medicinal chemistry (13.07.2006)
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PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
LO WILLIAM C, HUNTER JAMES E, BORUWA JOSHODEEP, WATSON GERALD B, IYER PRAVIN S, PATNY AKSHAY
Year of Publication 31.08.2015
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Year of Publication 31.08.2015
Patent
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
LO WILLIAM C, HUNTER JAMES E, BORUWA JOSHODEEP, WATSON GERALD B, IYER PRAVIN S, PATNY AKSHAY
Year of Publication 27.08.2015
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Year of Publication 27.08.2015
Patent
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
LO WILLIAM C, HUNTER JAMES E, BORUWA JOSHODEEP, WATSON GERALD B, IYER PRAVIN S, PATNY AKSHAY
Year of Publication 26.08.2015
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Year of Publication 26.08.2015
Patent
PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
LO WILLIAM C, HUNTER JAMES E, BORUWA JOSHODEEP, WATSON GERALD B, IYER PRAVIN S, PATNY AKSHAY
Year of Publication 26.08.2015
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Year of Publication 26.08.2015
Patent
Bioassay for the Identification of Natural Product-Based Activators of Peroxisome Proliferator-Activated Receptor-γ (PPARγ): The Marine Sponge Metabolite Psammaplin A Activates PPARγ and Induces Apoptosis in Human Breast Tumor Cells
Mora, Flor D, Jones, Deborah K, Desai, Prashant V, Patny, Akshay, Avery, Mitchell A, Feller, Dennis R, Smillie, Troy, Zhou, Yu-Dong, Nagle, Dale G
Published in Journal of natural products (Washington, D.C.) (01.04.2006)
Published in Journal of natural products (Washington, D.C.) (01.04.2006)
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PESTICIDAL COMPOSITIONS AND RELATED METHODS
LOWE CHRISTIAN T, KNUEPPEL DANIEL, DEMETER DAVID A, LEPLAE PAUL R, TRULLINGER TONY K, GARIZI NEGAR, PATNY AKSHAY, ZHANG YU, WALSH MARTIN J, BUYSSE ANN M, HUNTER RICKY, NIYAZ NOORMOHAMED M
Year of Publication 29.06.2016
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Year of Publication 29.06.2016
Patent
BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS AND THEIR USE AS IRAK4 INHIBITORS
ZAPF CHRISTOPH WOLFGANG, ANDERSON DAVID RANDOLPH, DEHNHARDT CHRISTOPH MARTIN, BUNNAGE MARK EDWARD, VARGAS RICHARD, PAPAIOANNOU NIKOLAOS, LEE ARTHUR, LEE KATHERINE LIN, STROHBACH JOSEPH WALTER, TRZUPEK JOHN DAVID, WANG XIAOLUN, PATNY AKSHAY, LOVERING FRANK ELDRIDGE, PIERCE BETSY SUSAN, HUANG HORNG CHIH, WRIGHT STEPHEN WAYNE, GOLDBERG JOEL ADAM, SAIAH EDDINE, HEPWORTH DAVID, CURRAN KEVIN JOSEPH, LOWE MICHAEL DENNIS, GAVRIN LORI KRIM, MATHIAS JOHN PAUL, HAN SEUNGIL
Year of Publication 25.11.2016
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Year of Publication 25.11.2016
Patent
Design, synthesis, and docking studies of telmisartan analogs for the treatment of metabolic syndrome
Mizuno, Cassia S, Chittiboyina, Amar G, Patny, Akshay, Kurtz, Theodore W, Pershadsingh, Harrihar A, Speth, Robert C, Karamyan, Vardan T, Avery, Mitchell A
Published in Medicinal chemistry research (01.11.2009)
Published in Medicinal chemistry research (01.11.2009)
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Design, synthesis, and docking studies of novel telmisartan-glitazone hybrid analogs for the treatment of metabolic syndrome
Chittiboyina, Amar G, Mizuno, Cassia S, Desai, Prashant V, Patny, Akshay, Kurtz, Theodore W, Pershadsingh, Harrihar A, Speth, Robert C, Karamyan, Vardan, Avery, Mitchell A
Published in Medicinal chemistry research (01.09.2009)
Published in Medicinal chemistry research (01.09.2009)
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