Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice
Helsley, Robert N, Miyata, Tatsunori, Kadam, Anagha, Varadharajan, Venkateshwari, Sangwan, Naseer, Huang, Emily C, Banerjee, Rakhee, Brown, Amanda L, Fung, Kevin K, Massey, William J, Neumann, Chase, Orabi, Danny, Osborn, Lucas J, Schugar, Rebecca C, McMullen, Megan R, Bellar, Annette, Poulsen, Kyle L, Kim, Adam, Pathak, Vai, Mrdjen, Marko, Anderson, James T, Willard, Belinda, McClain, Craig J, Mitchell, Mack, McCullough, Arthur J, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Garcia-Garcia, Jose Carlos, Rotroff, Daniel M, Allende, Daniela S, Wang, Zeneng, Hazen, Stanley L, Nagy, Laura E, Brown, Jonathan Mark
Published in eLife (27.01.2022)
Published in eLife (27.01.2022)
Get full text
Journal Article
Membrane-bound O -acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Gulshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark
Published in eLife (22.04.2024)
Published in eLife (22.04.2024)
Get full text
Journal Article
Multiomics-Identified Intervention to Restore Ethanol-Induced Dysregulated Proteostasis and Secondary Sarcopenia in Alcoholic Liver Disease
Singh, Shashi Shekhar, Kumar, Avinash, Welch, Nicole, Sekar, Jinendiran, Mishra, Saurabh, Bellar, Annette, Gangadhariah, Mahesha, Attaway, Amy, Al Khafaji, Hayder, Wu, Xiaoqin, Pathak, Vai, Agrawal, Vandana, McMullen, Megan R, Hornberger, Troy A, Nagy, Laura E, Davuluri, Gangarao, Dasarathy, Srinivasan
Published in Cellular physiology and biochemistry (06.02.2021)
Published in Cellular physiology and biochemistry (06.02.2021)
Get full text
Journal Article
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth
Nandadasa, Sumeda, Szafron, Jason M, Pathak, Vai, Murtada, Sae-Il, Kraft, Caroline M, O'Donnell, Anna, Norvik, Christian, Hughes, Clare, Caterson, Bruce, Domowicz, Miriam S, Schwartz, Nancy B, Tran-Lundmark, Karin, Veigl, Martina, Sedwick, David, Philipson, Elliot H, Humphrey, Jay D, Apte, Suneel S
Published in eLife (10.09.2020)
Published in eLife (10.09.2020)
Get full text
Journal Article
Phosphoproteomics identifies pathways underlying the role of receptor‐interaction protein kinase 3 in alcohol‐associated liver disease and uncovers apoptosis signal‐regulating kinase 1 as a target
Singh, Vaibhav, Huang, Emily, Pathak, Vai, Willard, Belinda B., Allende, Daniela S., Nagy, Laura E.
Published in Hepatology communications (01.08.2022)
Published in Hepatology communications (01.08.2022)
Get full text
Journal Article
Altered anti-viral immune responses in monocytes in overweight heavy drinkers
Kim, Adam, Ortega-Ribera, Martí, McMullen, Megan R., Bellar, Annette, Taiwo, Moyinoluwa, Pathak, Vai, Streem, David, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Vachharajani, Vidula, Nagy, Laura E.
Published in iScience (21.07.2023)
Published in iScience (21.07.2023)
Get full text
Journal Article
THU-330 Complement protein signatures in patients with alcohol-associated hepatitis
Nagy, Laura, Taiwo, Moyinoluwa, Huang, Emily, Pathak, Vai, Schaefer, Esperance, Luther, Jay, Day, Le, Jacobs, Jon, Goodman, Russell, Rotroff, Daniel, Szabo, Gyongyi
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
Get full text
Journal Article
Macrophage-derived MLKL in alcohol-associated liver disease: Regulation of phagocytosis
Wu, Xiaoqin, Fan, Xiude, McMullen, Megan R, Miyata, Tatsunori, Kim, Adam, Pathak, Vai, Wu, Jianguo, Day, Le Z, Hardesty, Josiah E, Welch, Nicole, Dasarathy, Jaividhya, Allende, Daniela S, McCullough, Arthur J, Jacobs, Jon M, Rotroff, Daniel M, Dasarathy, Srinivasan, Nagy, Laura E
Published in Hepatology (Baltimore, Md.) (01.03.2023)
Published in Hepatology (Baltimore, Md.) (01.03.2023)
Get full text
Journal Article
Role of macrophage-derived MLKL in alcohol-associated liver disease
Wu, Xiaoqin, Fan, Xiude, McMullen, Megan, Miyata, Tatsunori, Kim, Adam, Pathak, Vai, Wu, Jianguo, Welch, Nicole, Dasarathy, Jaividhya, Dasarathy, Srinivasan, Nagy, Laura
Published in Journal of hepatology (01.07.2022)
Published in Journal of hepatology (01.07.2022)
Get full text
Journal Article
Phosphoproteomic analysis reveals pathways underlying the role of receptor interacting protein kinase 3 (RIP3) in alcohol-associated liver disease and uncovers apoptosis signal-regulating kinase 1 (ASK1) as an important target
Singh, Vaibhav, Huang, Emily, Pathak, Vai, Willard, Belinda B., Nagy, Laura E.
Published in Alcohol (Fayetteville, N.Y.) (01.11.2021)
Published in Alcohol (Fayetteville, N.Y.) (01.11.2021)
Get full text
Journal Article
Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury
Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Gulshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark
Published in eLife (22.04.2024)
Published in eLife (22.04.2024)
Get full text
Journal Article
Dysregulated meta-organismal metabolism of aromatic amino acids in alcohol-associated liver disease
Mrdjen, Marko, Huang, Emily, Pathak, Vai, Bellar, Annette, Welch, Nicole, Dasarathy, Jaividhya, Streem, David, McClain, Craig J, Mitchell, Mack, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Wang, Zeneng, Hazen, Stanley L, Brown, J Mark, Nagy, Laura E
Published in Hepatology communications (01.11.2023)
Published in Hepatology communications (01.11.2023)
Get full text
Journal Article
Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis
Taiwo, Moyinoluwa, Huang, Emily, Pathak, Vai, Bellar, Annette, Welch, Nicole, Dasarathy, Jaividhya, Streem, David, McClain, Craig J, Mitchell, Mack C, Barton, Bruce A, Szabo, Gyongyi, Dasarathy, Srinivasan, Schaefer, Esperance A, Luther, Jay, Day, Le Z, Ouyang, Xinshou, Suyavaran, Arumugam, Mehal, Wajahat Z, Jacobs, Jon M, Goodman, Russell P, Rotroff, Daniel M, Nagy, Laura E
Published in JCI insight (08.05.2024)
Published in JCI insight (08.05.2024)
Get full text
Journal Article
Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis
Overstreet, Anne-Marie C, Burge, McKenzie, Bellar, Annette, McMullen, Megan, Czarnecki, Douglas, Huang, Emily, Pathak, Vai, Finney, Chelsea, Vij, Raveena, Dasarathy, Srinivasan, Dasarathy, Jaividhya, Streem, David, Welch, Nicole, Rotroff, Daniel, Schmitt, Adam M, Nagy, Laura E, Messer, Jeannette S
Published in medRxiv : the preprint server for health sciences (06.09.2024)
Get more information
Published in medRxiv : the preprint server for health sciences (06.09.2024)
Journal Article
Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
Varadharajan, Venkateshwari, Ramachandiran, Lyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Guilshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark
Published in bioRxiv : the preprint server for biology (10.01.2024)
Get more information
Published in bioRxiv : the preprint server for biology (10.01.2024)
Journal Article
Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice
Helsley, Robert N, Miyata, Tatsunori, Kadam, Anagha, Varadharajan Venkateshwari, Sangwan, Naseer, Huang, Emily C, Banerjee, Rakhee, Brown, Amanda L, Fung, Kevin K, Massey, William, Neumann, Chase, Orabi Danny, Osborn, Lucas J, Schugar, Rebecca C, Mcmullen, Megan R, Bellar, Annette, Poulsen, Kyle L, Kim, Adam, Pathak, Vai, Mrdjen, Marko, Anderson, James T, Willard, Belinda, Mcclain, Craig J, Mack, Mitchell, Mccullough, Arthur J, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Srinivasan Dasarathy, Garcia-Garcia, Jose Carlos, Rotroff, Daniel M, Allende, Daniela S, Wang, Zeneng, Hazen, Stanley L, Nagy, Laura E, Brown, Jonathan Mark
Published in bioRxiv (01.01.2022)
Published in bioRxiv (01.01.2022)
Get full text
Paper
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth
Nandadasa, Sumeda, Szafron, Jason M, Pathak, Vai, Sae-Il Murtada, Craft, Caroline M, O'donnell, Anna, Norvik, Christian, Hughes, Clare, Caterson, Bruce, Domowicz, Miriam S, Schwartz, Nancy B, Tran-Lundmark, Karin, Veigl, Martina, Sedwick, David, Philipson, Elliot H, Humphrey, Jay D, Apte, Suneel S
Published in bioRxiv (03.07.2020)
Published in bioRxiv (03.07.2020)
Get full text
Paper