RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Patel, Snahel, Webster, Joshua D, Varfolomeev, Eugene, Kwon, Youngsu C, Cheng, Jason H, Zhang, Juan, Dugger, Debra L, Wickliffe, Kate E, Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M, Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P, van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S, Junttila, Melissa R, Newton, Kim, Vucic, Domagoj
Published in Cell death and differentiation (01.01.2020)
Published in Cell death and differentiation (01.01.2020)
Get full text
Journal Article
Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
Grafton, Francis, Ho, Jaclyn, Ranjbarvaziri, Sara, Farshidfar, Farshad, Budan, Anastasiia, Steltzer, Stephanie, Maddah, Mahnaz, Loewke, Kevin E, Green, Kristina, Patel, Snahel, Hoey, Tim, Mandegar, Mohammad Ali
Published in eLife (02.08.2021)
Published in eLife (02.08.2021)
Get full text
Journal Article
Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease
Le Pichon, Claire E, Meilandt, William J, Dominguez, Sara, Solanoy, Hilda, Lin, Han, Ngu, Hai, Gogineni, Alvin, Sengupta Ghosh, Arundhati, Jiang, Zhiyu, Lee, Seung-Hye, Maloney, Janice, Gandham, Vineela D, Pozniak, Christine D, Wang, Bei, Lee, Sebum, Siu, Michael, Patel, Snahel, Modrusan, Zora, Liu, Xingrong, Rudhard, York, Baca, Miriam, Gustafson, Amy, Kaminker, Josh, Carano, Richard A D, Huang, Eric J, Foreman, Oded, Weimer, Robby, Scearce-Levie, Kimberly, Lewcock, Joseph W
Published in Science translational medicine (16.08.2017)
Published in Science translational medicine (16.08.2017)
Get more information
Journal Article
Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: Alleviating hERG interactions through structure based design
Patel, Snahel D., Habeski, Wendy M., Cheng, Alan C., de la Cruz, Elisa, Loh, Christine, Kablaoui, Natasha M.
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Published in Bioorganic & medicinal chemistry letters (15.06.2009)
Get full text
Journal Article
Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective α2C adrenergic receptor antagonist
PATEL, Snahel D, HABESKI, Wendy M, JOHNSON, Douglas S, CHAUDHRY, Archana, CHARLTON, Maura E, KABLAOUI, Natasha M, MIN, Hyunsuk, JIANSU ZHANG, ROOF, Robin, SNYDER, Bradley, BORA, Gary, CAMPBELL, Brian, LI, Cheryl, HIDAYETOGLU, Debra
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Get full text
Journal Article
RIP1 kinase activity is critical for skin inflammation but not for viral propagation
Webster, Joshua D., Kwon, Youngsu C., Park, Summer, Zhang, Hua, Corr, Nick, Ljumanovic, Nina, Adedeji, Adeyemi O., Varfolomeev, Eugene, Goncharov, Tatiana, Preston, Jessica, Santagostino, Sara F., Patel, Snahel, Xu, Min, Maher, Jonathan, McKenzie, Brent S., Vucic, Domagoj
Published in Journal of leukocyte biology (01.06.2020)
Published in Journal of leukocyte biology (01.06.2020)
Get full text
Journal Article
Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer’s Disease
Patel, Snahel, Meilandt, William J, Erickson, Rebecca I, Chen, Jinhua, Deshmukh, Gauri, Estrada, Anthony A, Fuji, Reina N, Gibbons, Paul, Gustafson, Amy, Harris, Seth F, Imperio, Jose, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Lyssikatos, Joseph P, Ma, Changyou, Yin, Jianping, Lewcock, Joseph W, Siu, Michael
Published in Journal of medicinal chemistry (12.10.2017)
Published in Journal of medicinal chemistry (12.10.2017)
Get full text
Journal Article
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors
Hu, Dennis X., Patel, Snahel, Chen, Huifen, Wang, Shumei, Staben, Steven T., Dimitrova, Yoana N., Wallweber, Heidi Ackerly, Lee, Joanna Y., Chan, Grace Ka Yan, Sneeringer, Christopher J., Prangley, Madeleine S., Moffat, John G., Wu, Kai C., Schutt, Leah K., Salphati, Laurent, Pang, Jodie, McNamara, Erin, Huang, Haochu, Chen, Yong, Wang, Yunli, Zhao, Wensheng, Lim, Junghyun, Murthy, Aditya, Siu, Michael
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
Get full text
Journal Article
BICYCLIC KETONE COMPOUNDS AND METHODS OF USE THEREOF
ZHAO GUILING, CHEN HUIFEN, HAMILTON GREGORY, STIVALA CRAIG, DANIELS BLAKE, PATEL SNAHEL
Year of Publication 14.05.2024
Get full text
Year of Publication 14.05.2024
Patent
Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group
Hamilton, Gregory L., Chen, Huifen, Deshmukh, Gauri, Eigenbrot, Charles, Fong, Rina, Johnson, Adam, Kohli, Pawan Bir, Lupardus, Patrick J., Liederer, Bianca M., Ramaswamy, Sreemathy, Wang, Haowei, Wang, Jian, Xu, Zhaowu, Zhu, Yunliang, Vucic, Domagoj, Patel, Snahel
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Published in Bioorganic & medicinal chemistry letters (15.06.2019)
Get full text
Journal Article
Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N‑(1H‑Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12)
Patel, Snahel, Harris, Seth F, Gibbons, Paul, Deshmukh, Gauri, Gustafson, Amy, Kellar, Terry, Lin, Han, Liu, Xingrong, Liu, Yanzhou, Liu, Yichin, Ma, Changyou, Scearce-Levie, Kimberly, Ghosh, Arundhati Sengupta, Shin, Young G, Solanoy, Hilda, Wang, Jian, Wang, Bei, Yin, Jianping, Siu, Michael, Lewcock, Joseph W
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
Get full text
Journal Article
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors
Liang, Jun, Labadie, Sharada, Zhang, Birong, Ortwine, Daniel F., Patel, Snahel, Vinogradova, Maia, Kiefer, James R., Mauer, Till, Gehling, Victor S., Harmange, Jean-Christophe, Cummings, Richard, Lai, Tommy, Liao, Jiangpeng, Zheng, Xiaoping, Liu, Yichin, Gustafson, Amy, Van der Porten, Erica, Mao, Weifeng, Liederer, Bianca M., Deshmukh, Gauri, An, Le, Ran, Yingqing, Classon, Marie, Trojer, Patrick, Dragovich, Peter S., Murray, Lesley
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Published in Bioorganic & medicinal chemistry letters (01.07.2017)
Get full text
Journal Article
KRAS G12C 억제제
TANAKA HIROKO, WILLIAMS MONIKA JANE, WIDEN JOHN C, DOTSENKO IRINA, GERKEN PHILIP A, ERLANSON DANIEL A, PATEL SNAHEL
Year of Publication 24.07.2024
Get full text
Year of Publication 24.07.2024
Patent
Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models
Patel, Snahel, Cohen, Frederick, Dean, Brian J., De La Torre, Kelly, Deshmukh, Gauri, Estrada, Anthony A., Ghosh, Arundhati Sengupta, Gibbons, Paul, Gustafson, Amy, Huestis, Malcolm P., Le Pichon, Claire E., Lin, Han, Liu, Wendy, Liu, Xingrong, Liu, Yichin, Ly, Cuong Q., Lyssikatos, Joseph P., Ma, Changyou, Scearce-Levie, Kimberly, Shin, Young G., Solanoy, Hilda, Stark, Kimberly L., Wang, Jian, Wang, Bei, Zhao, Xianrui, Lewcock, Joseph W., Siu, Michael
Published in Journal of medicinal chemistry (08.01.2015)
Published in Journal of medicinal chemistry (08.01.2015)
Get full text
Journal Article
Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors
Zak, Mark, Yuen, Po-wai, Liu, Xiongcai, Patel, Snahel, Sampath, Deepak, Oeh, Jason, Liederer, Bianca M, Wang, Weiru, O’Brien, Thomas, Xiao, Yang, Skelton, Nicholas, Hua, Rongbao, Sodhi, Jasleen, Wang, Yunli, Zhang, Lei, Zhao, Guiling, Zheng, Xiaozhang, Ho, Yen-Ching, Bair, Kenneth W, Dragovich, Peter S
Published in Journal of medicinal chemistry (22.09.2016)
Published in Journal of medicinal chemistry (22.09.2016)
Get full text
Journal Article
2고리 설폰 및 설폭사이드, 및 이의 사용 방법
CHEN HUIFEN, HAMILTON GREGORY, STIVALA CRAIG, DANIELS BLAKE, PATEL SNAHEL
Year of Publication 08.07.2020
Get full text
Year of Publication 08.07.2020
Patent
BICYCLIC LACTAMS AND METHODS OF USE THEREOF
ZHAO GUILING, CHEN HUIFEN, HAMILTON GREGORY, STIVALA CRAIG, PATEL SNAHEL
Year of Publication 31.12.2019
Get full text
Year of Publication 31.12.2019
Patent