Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation
Jurado, Kellie A., Wang, Hao, Slaughter, Alison, Feng, Lei, Kessl, Jacques J., Koh, Yasuhiro, Wang, Weifeng, Ballandras-Colas, Allison, Patel, Pratiq A., Fuchs, James R., Kvaratskhelia, Mamuka, Engelman, Alan
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (21.05.2013)
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The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
Feng, Lei, Sharma, Amit, Slaughter, Alison, Jena, Nivedita, Koh, Yasuhiro, Shkriabai, Nikolozi, Larue, Ross C., Patel, Pratiq A., Mitsuya, Hiroaki, Kessl, Jacques J., Engelman, Alan, Fuchs, James R., Kvaratskhelia, Mamuka
Published in The Journal of biological chemistry (31.05.2013)
Published in The Journal of biological chemistry (31.05.2013)
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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling
Abbott, Jason R, Hodges, Timothy R, Daniels, R. Nathan, Patel, Pratiq A, Kennedy, J. Phillip, Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Sai, Jiqing, Sobolik, Tammy, Beesetty, Yugandhar, Lee, Taekyu, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Journal Article
Indole-based allosteric inhibitors of HIV-1 integrase
Patel, Pratiq A., Kvaratskhelia, Nina, Mansour, Yara, Antwi, Janet, Feng, Lei, Koneru, Pratibha, Kobe, Mathew J., Jena, Nivedita, Shi, Guqin, Mohamed, Mosaad S., Li, Chenglong, Kessl, Jacques J., Fuchs, James R.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
Wang, Hao, Jurado, Kellie A, Wu, Xiaolin, Shun, Ming-Chieh, Li, Xiang, Ferris, Andrea L, Smith, Steven J, Patel, Pratiq A, Fuchs, James R, Cherepanov, Peter, Kvaratskhelia, Mamuka, Hughes, Stephen H, Engelman, Alan
Published in Nucleic acids research (01.12.2012)
Published in Nucleic acids research (01.12.2012)
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Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones
Woodard, John L., Huntsman, Andrew C., Patel, Pratiq A., Chai, Hee-Byung, Kanagasabai, Ragu, Karmahapatra, Soumendrakrishna, Young, Alexandria N., Ren, Yulin, Cole, Malcolm S., Herrera, Denisse, Yalowich, Jack C., Kinghorn, A. Douglas, Burdette, Joanna E., Fuchs, James R.
Published in Bioorganic & medicinal chemistry (15.05.2018)
Published in Bioorganic & medicinal chemistry (15.05.2018)
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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS
Abbott, Jason R, Patel, Pratiq A, Howes, Jennifer E, Akan, Denis T, Kennedy, J. Phillip, Burns, Michael C, Browning, Carrie F, Sun, Qi, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W
Published in ACS medicinal chemistry letters (13.09.2018)
Published in ACS medicinal chemistry letters (13.09.2018)
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The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
Slaughter, Alison, Jurado, Kellie A, Deng, Nanjie, Feng, Lei, Kessl, Jacques J, Shkriabai, Nikoloz, Larue, Ross C, Fadel, Hind J, Patel, Pratiq A, Jena, Nivedita, Fuchs, James R, Poeschla, Eric, Levy, Ronald M, Engelman, Alan, Kvaratskhelia, Mamuka
Published in Retrovirology (25.11.2014)
Published in Retrovirology (25.11.2014)
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Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process
Wang, Tao, Phillips, Eric M, Dalby, Stephen M, Sirota, Eric, Axnanda, Stephanus, Shultz, C. Scott, Patel, Pratiq, Waldman, Jacob H, Alwedi, Embarek, Wang, Xiao, Zawatzky, Kerstin, Chow, Matthew, Padivitage, Nilusha, Weisel, Mark, Whittington, Michael, Duan, Jianjun, Lu, Taotao
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Franklin, Robert D., Armiger, Travis, Otte, Douglas A. L., Larson, Reed T., Spencer, Glenn, Patel, Pratiq A., Paulines, Mellie June, Hall, Jackson R., Xiao, Kai-Jiong, Fier, Patrick S., Rodrigues, Vailankanni L., Guetschow, Erik D., Kuhl, Nadine, Jellett, Lisa, Corry, James, Chung, Cheol K., Thaisrivongs, David A.
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Otte, Douglas A. L., Larson, Reed T., Alwedi, Embarek, Armiger, Travis, Chen, Yonggang, Chung, Cheol K., Corry, James, Desmond, Richard, Fier, Patrick S., Franklin, Robert D., Guetschow, Erik D., Hall, Jackson R., Halsey, Holst M., Hartmanshenn, Clara, Jellett, Lisa, Kuhl, Nadine, Lévesque, François, McMullen, Jonathan P., Patel, Pratiq A., Paulines, Mellie June, Ren, Hong, Rodrigues, Vailankanni L., Ruccolo, Serge, Tan, Lushi, Thaisrivongs, David A., Xiao, Kai-Jiong
Published in Organic process research & development (17.05.2024)
Published in Organic process research & development (17.05.2024)
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The mechanism of H171T resistance reveals the importance of N[delta]-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
Slaughter, Alison, Jurado, Kellie A, Deng, Nanjie, Feng, Lei, Kessl, Jacques J, Shkriabai, Nikoloz, Larue, Ross C, Fadel, Hind J, Patel, Pratiq A, Jena, Nivedita, Fuchs, James R, Poeschla, Eric, Levy, Ronald M, Engelman, Alan, Kvaratskhelia, Mamuka
Published in Retrovirology (25.11.2014)
Published in Retrovirology (25.11.2014)
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Journal Article
The mechanism of H171T resistance reveals the importance of N sub( delta )-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase
Slaughter, Alison, Jurado, Kellie A, Deng, Nanjie, Feng, Lei, Kessl, Jacques J, Shkriabai, Nikoloz, Larue, Ross C, Fadel, Hind J, Patel, Pratiq A, Jena, Nivedita, Fuchs, James R, Poeschla, Eric, Levy, Ronald M, Engelman, Alan, Kvaratskhelia, Mamuka
Published in Retrovirology (01.01.2014)
Published in Retrovirology (01.01.2014)
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Quinazoline compounds as modulators of Ras signaling
Fesik, Stephen W, Burns, Michael C, Abbott, Jason R, Patel, Pratiq, Waterson, Alex G, Phan, Jason, Kennedy, J. Phillip, Sun, Qi
Year of Publication 03.05.2022
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Year of Publication 03.05.2022
Patent
QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING
Fesik, Stephen W, Burns, Michael C, Abbott, Jason R, Patel, Pratiq, Waterson, Alex G, Phan, Jason, Kennedy, J. Phillip, Sun, Qi
Year of Publication 13.08.2020
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Year of Publication 13.08.2020
Patent
QUINAZOLINE COMPOUNDS AS MODULATORS OF RAS SIGNALING
KENNEDY, J. Phillip, PATEL, Pratiq, ABBOTT, Jason R, FESIK, Stephen W, BURNS, Michael C, PHAN, Jason, WATERSON, Alex G, SUN, Qi
Year of Publication 22.11.2018
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Year of Publication 22.11.2018
Patent