In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
Sharma, Vikas K., Patapoff, Thomas W., Kabakoff, Bruce, Pai, Satyan, Hilario, Eric, Zhang, Boyan, Li, Charlene, Borisov, Oleg, Kelley, Robert F., Chorny, Ilya, Zhou, Joe Z., Dill, Ken A., Swartz, Trevor E.
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (30.12.2014)
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Journal Article
Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload
Adem, Yilma T, Schwarz, Kelly A, Duenas, Eileen, Patapoff, Thomas W, Galush, William J, Esue, Osigwe
Published in Bioconjugate chemistry (16.04.2014)
Published in Bioconjugate chemistry (16.04.2014)
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Journal Article
In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Bown, Hanne Kinnunen, Bonn, Catherine, Yohe, Stefan, Yadav, Daniela Bumbaca, Patapoff, Thomas W., Daugherty, Ann, Mrsny, Randall J.
Published in Journal of controlled release (10.03.2018)
Published in Journal of controlled release (10.03.2018)
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Journal Article
A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components
Kinnunen, Hanne M., Sharma, Vikas, Contreras-Rojas, Luis Rodrigo, Yu, Yafei, Alleman, Chlöe, Sreedhara, Alavattam, Fischer, Stefan, Khawli, Leslie, Yohe, Stefan T., Bumbaca, Daniela, Patapoff, Thomas W., Daugherty, Ann L., Mrsny, Randall J.
Published in Journal of controlled release (28.09.2015)
Published in Journal of controlled release (28.09.2015)
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Journal Article
Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies
Chaudhri, Anuj, Zarraga, Isidro E, Kamerzell, Tim J, Brandt, J. Paul, Patapoff, Thomas W, Shire, Steven J, Voth, Gregory A
Published in The journal of physical chemistry. B (19.07.2012)
Published in The journal of physical chemistry. B (19.07.2012)
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Journal Article
Protein Aggregation in Frozen Trehalose Formulations: Effects of Composition, Cooling Rate, and Storage Temperature
Connolly, Brian D., Le, Lan, Patapoff, Thomas W., Cromwell, Mary E.M., Moore, Jamie M.R., Lam, Philippe
Published in Journal of pharmaceutical sciences (01.12.2015)
Published in Journal of pharmaceutical sciences (01.12.2015)
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Journal Article
The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling
Chaudhri, Anuj, Zarraga, Isidro E, Yadav, Sandeep, Patapoff, Thomas W, Shire, Steven J, Voth, Gregory A
Published in The journal of physical chemistry. B (07.02.2013)
Published in The journal of physical chemistry. B (07.02.2013)
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Journal Article
Trehalose Limits BSA Aggregation in Spray-Dried Formulations at High Temperatures: Implications in Preparing Polymer Implants for Long-Term Protein Delivery
Rajagopal, Karthikan, Wood, Joseph, Tran, Benjamin, Patapoff, Thomas W., Nivaggioli, Thierry
Published in Journal of pharmaceutical sciences (01.08.2013)
Published in Journal of pharmaceutical sciences (01.08.2013)
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Journal Article
Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody
Brandt, J. Paul, Patapoff, Thomas W., Aragon, Sergio R.
Published in Biophysical journal (04.08.2010)
Published in Biophysical journal (04.08.2010)
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Journal Article
Molecular Simulations of the Pairwise Interaction of Monoclonal Antibodies
Lapelosa, Mauro, Patapoff, Thomas W, Zarraga, Isidro E
Published in The journal of physical chemistry. B (20.11.2014)
Published in The journal of physical chemistry. B (20.11.2014)
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Journal Article
Polysorbate 20 prevents the precipitation of a monoclonal antibody during shear
Patapoff, Thomas W, Esue, Osigwe
Published in Pharmaceutical development and technology (01.12.2009)
Published in Pharmaceutical development and technology (01.12.2009)
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Journal Article
Opposite Effects of Polyols on Antibody Aggregation: Thermal Versus Mechanical Stresses
Abbas, Shermeen A., Sharma, Vikas K., Patapoff, Thomas W., Kalonia, Devendra S.
Published in Pharmaceutical research (01.03.2012)
Published in Pharmaceutical research (01.03.2012)
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Journal Article
Multiscale Coarse-Grained Approach to Investigate Self-Association of Antibodies
Izadi, Saeed, Patapoff, Thomas W., Walters, Benjamin T.
Published in Biophysical journal (02.06.2020)
Published in Biophysical journal (02.06.2020)
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Journal Article
Mutational landscape of antibody variable domains reveals a switch modulating the interdomain conformational dynamics and antigen binding
Koenig, Patrick, Lee, Chingwei V., Walters, Benjamin T., Janakiraman, Vasantharajan, Stinson, Jeremy, Patapoff, Thomas W., Fuh, Germaine
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.01.2017)
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Journal Article
Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying
Sundaramurthi, Prakash, Patapoff, Thomas W, Suryanarayanan, Raj
Published in Pharmaceutical research (01.11.2010)
Published in Pharmaceutical research (01.11.2010)
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Journal Article
Influence of glycosylation pattern on the molecular properties of monoclonal antibodies
Zheng, Kai, Yarmarkovich, Mark, Bantog, Christopher, Bayer, Robert, Patapoff, Thomas W
Published in mAbs (01.05.2014)
Published in mAbs (01.05.2014)
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Journal Article