Plasma mitochondrial DNA is elevated in obese type 2 diabetes mellitus patients and correlates positively with insulin resistance
Yuzefovych, Larysa V, Pastukh, Viktor M, Ruchko, Mykhaylo V, Simmons, Jon D, Richards, William O, Rachek, Lyudmila I
Published in PloS one (10.10.2019)
Published in PloS one (10.10.2019)
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Journal Article
Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription
Al-Mehdi, Abu-Bakr, Pastukh, Viktor M, Swiger, Brad M, Reed, Darla J, Patel, Mita R, Bardwell, Gina C, Pastukh, Viktoriya V, Alexeyev, Mikhail F, Gillespie, Mark N
Published in Science signaling (03.07.2012)
Published in Science signaling (03.07.2012)
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Journal Article
Effect of Bariatric Surgery on Plasma Cell-Free Mitochondrial DNA, Insulin Sensitivity and Metabolic Changes in Obese Patients
Yuzefovych, Larysa V, Pastukh, Viktor M, Mulekar, Madhuri S, Ledbetter, Kate, Richards, William O, Rachek, Lyudmila I
Published in Biomedicines (01.09.2023)
Published in Biomedicines (01.09.2023)
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Journal Article
Novel attributes of cell‐free plasma mitochondrial DNA in traumatic injury
Daly, Grant T., Pastukh, Viktor M., Tan, Yong B., Francis, C. Michael, Aggen, C. Zack, Groark, S. Chris, Edwards, Carson, Mulekar, Madhuri S., Hamo, Mohammad, Simmons, Jon D., Kutcher, Matthew E., Hartsell, Emily M., Dinwiddie, Darrell L., Turpin, Zachary M., Bass, Hank W., Roberts, Justin T., Gillespie, Mark N., Langley, Raymond J.
Published in Clinical and translational medicine (01.10.2022)
Published in Clinical and translational medicine (01.10.2022)
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Journal Article
Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences
Pastukh, Viktor M, Zhang, Li, Ruchko, Mykhaylo V, Gorodnya, Olena, Bardwell, Gina C, Tuder, Rubin M, Gillespie, Mark N
Published in International journal of chronic obstructive pulmonary disease (01.01.2011)
Published in International journal of chronic obstructive pulmonary disease (01.01.2011)
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Journal Article
Mitochondrial DNA damage-associated molecular patterns mediate a feed-forward cycle of bacteria-induced vascular injury in perfused rat lungs
Kuck, Jamie L, Obiako, Boniface O, Gorodnya, Olena M, Pastukh, Viktor M, Kua, Justin, Simmons, Jon D, Gillespie, Mark N
Published in American journal of physiology. Lung cellular and molecular physiology (15.05.2015)
Published in American journal of physiology. Lung cellular and molecular physiology (15.05.2015)
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Journal Article
Potential contribution of mitochondrial DNA damage associated molecular patterns in transfusion products to the development of acute respiratory distress syndrome after multiple transfusions
Simmons, Jon D, Lee, Yann-Leei L, Pastukh, Viktor M, Capley, Gina, Muscat, Cherry A, Muscat, David C, Marshall, Michael L, Brevard, Sidney B, Gillespie, Mark N
Published in The journal of trauma and acute care surgery (01.06.2017)
Published in The journal of trauma and acute care surgery (01.06.2017)
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Journal Article
PFKFB3 Inhibits Fructose Metabolism in Pulmonary Microvascular Endothelial Cells
Lee, Ji Young, Stevens, Reece P, Pastukh, Viktoriya V, Pastukh, Viktor M, Kozhukhar, Natalya, Alexeyev, Mikhail F, Reisz, Julie A, Nerguizian, David, D'Alessandro, Angelo, Koloteva, Anna, Gwin, Meredith S, Roberts, Justin T, Borchert, Glen M, Wagener, Brant M, Pittet, Jean-François, Graham, Brian B, Stenmark, Kurt R, Stevens, Troy
Published in American journal of respiratory cell and molecular biology (01.09.2023)
Published in American journal of respiratory cell and molecular biology (01.09.2023)
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Journal Article
Mitochondrial DNA damage associated molecular patterns in ventilator-associated pneumonia: Prevention and reversal by intratracheal DNase I
Simmons, Jon D, Freno, Daniel R, Muscat, C Annie, Obiako, Boniface, Lee, Yann-Leei L, Pastukh, Viktor M, Brevard, Sidney B, Gillespie, Mark N
Published in The journal of trauma and acute care surgery (01.01.2017)
Published in The journal of trauma and acute care surgery (01.01.2017)
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Journal Article
Mitochondrial DNA Damage Initiates Acute Lung Injury and Multi-Organ System Failure Evoked in Rats by Intra-Tracheal Pseudomonas Aeruginosa
Lee, Yann-Leei, Obiako, Boniface, Gorodnya, Olena M, Ruchko, Mykhaylo V, Kuck, Jamie L, Pastukh, Viktor M, Wilson, Glenn L, Simmons, Jon D, Gillespie, Mark N
Published in Shock (Augusta, Ga.) (01.07.2017)
Published in Shock (Augusta, Ga.) (01.07.2017)
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Journal Article
Enhanced Mitochondrial DNA Repair Resuscitates Transplantable Lungs Donated After Circulatory Death
Tan, Yong B., Pastukh, Viktor M., Gorodnya, Olena M., Mulekar, Madhuri S., Simmons, Jon D., Machuca, Tiago N., Beaver, Thomas M., Wilson, Glenn L., Gillespie, Mark N.
Published in The Journal of surgical research (01.01.2020)
Published in The Journal of surgical research (01.01.2020)
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Journal Article
Plasma Transfusion Products and Contamination with Cellular and Associated Pro-Inflammatory Debris
Tan, Yong B., Rieske, Richard R., Audia, Jon P., Pastukh, Viktor M., Capley, Gina C., Gillespie, Mark N., Smith, Alison A., Tatum, Danielle M., Duchesne, Juan C., Kutcher, Matt E., Kerby, Jeffrey D., Simmons, Jon D.
Published in Journal of the American College of Surgeons (01.09.2019)
Published in Journal of the American College of Surgeons (01.09.2019)
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Journal Article
Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs
Chouteau, Joshua M, Obiako, Boniface, Gorodnya, Olena M, Pastukh, Viktor M, Ruchko, Mykhaylo V, Wright, Anthony J, Wilson, Glenn L, Gillespie, Mark N
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2011)
Published in American journal of physiology. Lung cellular and molecular physiology (01.12.2011)
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Journal Article
Controlled DNA “damage” and repair in hypoxic signaling
Gillespie, Mark N, Pastukh, Viktor M, Ruchko, Mykhaylo V
Published in Respiratory physiology & neurobiology (31.12.2010)
Published in Respiratory physiology & neurobiology (31.12.2010)
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Journal Article
Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes
Ruchko, Mykhaylo V., Gorodnya, Olena M., Pastukh, Viktor M., Swiger, Brad M., Middleton, Natavia S., Wilson, Glenn L., Gillespie, Mark N.
Published in Free radical biology & medicine (01.02.2009)
Published in Free radical biology & medicine (01.02.2009)
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Journal Article
The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells
Ruchko, Mykhaylo V., Gorodnya, Olena M., Zuleta, Andres, Pastukh, Viktor M., Gillespie, Mark N.
Published in Free radical biology & medicine (01.05.2011)
Published in Free radical biology & medicine (01.05.2011)
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Journal Article
Mitochondrial DNA DAMPs Induce Inflammation and Insulin Resistance
YUZEFOVYCH, LARYSA, PASTUKH, VIKTOR M., RACHEK, LYUDMILA
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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Journal Article