Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J
Published in Nature chemical biology (01.05.2017)
Published in Nature chemical biology (01.05.2017)
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Journal Article
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors
Khateb, Ali, Deshpande, Anagha, Feng, Yongmei, Finlay, Darren, Lee, Joo Sang, Lazar, Ikrame, Fabre, Bertrand, Li, Yan, Fujita, Yu, Zhang, Tongwu, Yin, Jun, Pass, Ian, Livneh, Ido, Jeremias, Irmela, Burian, Carol, Mason, James R, Almog, Ronit, Horesh, Nurit, Ofran, Yishai, Brown, Kevin, Vuori, Kristiina, Jackson, Michael, Ruppin, Eytan, Deshpande, Aniruddha J, Ronai, Ze'ev A
Published in Nature communications (13.09.2021)
Published in Nature communications (13.09.2021)
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Journal Article
Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation
Stylli, Stanley S, Stacey, T.T.I, Verhagen, Anne M, Xu, San San, Pass, Ian, Courtneidge, Sara A, Lock, Peter
Published in Journal of cell science (01.08.2009)
Published in Journal of cell science (01.08.2009)
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Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)
Lambert, Lester J, Grotegut, Stefan, Celeridad, Maria, Gosalia, Palak, Backer, Laurent Js De, Bobkov, Andrey A, Salaniwal, Sumeet, Chung, Thomas Dy, Zeng, Fu-Yue, Pass, Ian, Lombroso, Paul J, Cosford, Nicholas Dp, Tautz, Lutz
Published in International journal of molecular sciences (23.04.2021)
Published in International journal of molecular sciences (23.04.2021)
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The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
Seals, Darren F., Azucena, Eduardo F., Pass, Ian, Tesfay, Lia, Gordon, Rebecca, Woodrow, Melissa, Resau, James H., Courtneidge, Sara A.
Published in Cancer cell (01.02.2005)
Published in Cancer cell (01.02.2005)
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Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape
Farhy, Chen, Hariharan, Santosh, Ylanko, Jarkko, Orozco, Luis, Zeng, Fu-Yue, Pass, Ian, Ugarte, Fernando, Forsberg, E Camilla, Huang, Chun-Teng, Andrews, David W, Terskikh, Alexey V
Published in eLife (22.10.2019)
Published in eLife (22.10.2019)
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A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo
Blouw, Barbara, Seals, Darren F., Pass, Ian, Diaz, Begoña, Courtneidge, Sara A.
Published in European journal of cell biology (01.09.2008)
Published in European journal of cell biology (01.09.2008)
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Journal Article
The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells
Abram, Clare L., Seals, Darren F., Pass, Ian, Salinsky, Daniel, Maurer, Lisa, Roth, Therese M., Courtneidge, Sara A.
Published in The Journal of biological chemistry (09.05.2003)
Published in The Journal of biological chemistry (09.05.2003)
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The Lipid Phosphatase Activity of PTEN is Critical for Its Tumor Supressor Function
Myers, Michael P., Pass, Ian, Batty, Ian H., Van Der Kaay, Jeroen, Stolarov, Javor P., Hemmings, Brian A., Wigler, Michael H., Downes, C. Peter, Tonks, Nicholas K.
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (10.11.1998)
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TR-FRET-based high-throughput screening assay for identification of UBC13 inhibitors
Madiraju, Charitha, Welsh, Kate, Cuddy, Michael P, Godoi, Paulo H, Pass, Ian, Ngo, Tram, Vasile, Stefan, Sergienko, Eduard A, Diaz, Paul, Matsuzawa, Shu-Ichi, Reed, John C
Published in Journal of biomolecular screening (01.02.2012)
Published in Journal of biomolecular screening (01.02.2012)
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High-throughput screening of compounds targeting RNA editing in Trypanosoma brucei: Novel molecular scaffolds with broad trypanocidal effects
Rostamighadi, Mojtaba, Kamelshahroudi, Arezou, Mehta, Vaibhav, Zeng, Fu-Yue, Pass, Ian, Chung, Thomas D Y, Salavati, Reza
Published in Biochemical pharmacology (01.01.2024)
Published in Biochemical pharmacology (01.01.2024)
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EPEN-26. DRUG SCREENING IN PATIENT-DERIVED MODELS OF POSTERIOR FOSSA A EPENDYMOMA REVEALS NOVEL PHARMACOLOGICAL VULNERABILITIES
Larson, Jon D, Finlay, Darren, Murad, Rabi, Lo, Yan Yuen, Zhao, Ming, Manuvel, Antony Michealraj Kulandai, Kumar, Sachin A, Pass, Ian, Handley, Charles, Wechsler-Reya, Robert J, Taylor, Michael D, Vuori, Kristiina, Chavez, Lukas, Jackson, Michael
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
Published in Neuro-oncology (Charlottesville, Va.) (18.06.2024)
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Abstract C040: Discovery and development of novel ATG13 degrading compounds that inhibit autophagy and treat Non-Small Cell Lung Cancer
Hagan, Patrick M, Emami, Atoosa, Austin, Hilarie, Pass, Ian, Limpert, Allison, Sheffler, Douglas, Cosford, Nicholas
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Journal Article
Serine-Threonine Kinase TAO3-Mediated Trafficking of Endosomes Containing the Invadopodia Scaffold TKS5α Promotes Cancer Invasion and Tumor Growth
Iizuka, Shinji, Quintavalle, Manuela, Navarro, Jose C, Gribbin, Kyle P, Ardecky, Robert J, Abelman, Matthew M, Ma, Chen-Ting, Sergienko, Eduard, Zeng, Fu-Yue, Pass, Ian, Thomas, George V, McWeeney, Shannon K, Hassig, Christian A, Pinkerton, Anthony B, Courtneidge, Sara A
Published in Cancer research (Chicago, Ill.) (15.03.2021)
Published in Cancer research (Chicago, Ill.) (15.03.2021)
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RNF5 Defines Acute Myeloid Leukemia Growth and Susceptibility to Histone Deacetylase Inhibitors
Khateb, Ali, Deshpande, Anagha, Feng, Yongmei, Lazar, Ikrame, Lee, Joo Sang, Fabre, Bertrand, Li, Yan, Finlay, Darren, Fujita, Yu, Zhang, Tongwu, Pass, Ian, Livneh, Ido, Burian, Carol, Mason, James R., Almog, Ronit, Horesh, Nurit, Ofran, Yishai, Brown, Kevin, Vuori, Kristiina, Jackson, Michael, Ruppin, Eytan, Deshpande, Aniruddha J., Ronai, Ze'ev A.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells
Feng, Yongmei, Sessions, E. Hampton, Zhang, Fan, Ban, Fuqiang, Placencio-Hickok, Veronica, Ma, Chen-Ting, Zeng, Fu-Yue, Pass, Ian, Terry, David B., Cadwell, Gregory, Bankston, Laurie A., Liddington, Robert C., Chung, Thomas D.Y., Pinkerton, Anthony B., Sergienko, Eduard, Gleave, Martin, Bhowmick, Neil A., Jackson, Michael R., Cherkasov, Artem, Ronai, Ze'ev A.
Published in Cancer letters (01.05.2019)
Published in Cancer letters (01.05.2019)
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Journal Article
Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN
Patel, Lisa, Pass, Ian, Coxon, Phil, Downes, C.Peter, Smith, Stephen A., Macphee, Colin H.
Published in Current biology (15.05.2001)
Published in Current biology (15.05.2001)
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