Search Results - "Pascual, Rosalía" :: K.UTB vyhledávací portál

4‑Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ‑Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain

by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Fernández, Begoña, Port, Adriana, Pascual, Rosalía, Monroy, Xavier, Vidal-Torres, Alba, Serafini, María-Teresa, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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Bicyclic Diazepinones as Dual Ligands of the α2δ‑1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter

by Díaz, José Luis, Cuevas, Félix, Pazos, Gonzalo, Álvarez-Bercedo, Paula, Oliva, Ana I, Sarmentero, M. Ángeles, Font, Daniel, Jiménez-Aquino, Agustín, Morón, María, Port, Adriana, Pascual, Rosalía, Dordal, Albert, Portillo-Salido, Enrique, Reinoso, Raquel F, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (25.02.2021)

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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids

by Vidal-Torres, Alba, Fernández-Pastor, Begoña, García, Mónica, Ayet, Eva, Cabot, Anna, Burgueño, Javier, Monroy, Xavier, Aubel, Bertrand, Codony, Xavier, Romero, Luz, Pascual, Rosalía, Serafini, Maria Teresa, Encina, Gregorio, Almansa, Carmen, Zamanillo, Daniel, Merlos, Manuel, Vela, José Miguel
Published in Acta pharmaceutica Sinica. B (01.01.2023)

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WLB-87848, a Selective σ1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

by Christmann, Ute, Garriga, Lourdes, Llorente, Ana Virginia, Díaz, José Luis, Pascual, Rosalía, Bordas, Magda, Dordal, Albert, Porras, Mónica, Yeste, Sandra, Reinoso, Raquel F., Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (13.06.2024)

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A New Pharmacophore Model for the Design of Sigma-1 Ligands Validated on a Large Experimental Dataset

by Pascual, Rosalia, Almansa, Carmen, Plata-Salamán, Carlos, Vela, José Miguel
Published in Frontiers in pharmacology (31.05.2019)

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Critical comparison of shake-flask, potentiometric and chromatographic methods for lipophilicity evaluation (log Po/w) of neutral, acidic, basic, amphoteric, and zwitterionic drugs

by Port, Adriana, Bordas, Magda, Enrech, Raquel, Pascual, Rosalia, Rosés, Martí, Ràfols, Clara, Subirats, Xavier, Bosch, Elisabeth
Published in European journal of pharmaceutical sciences (15.09.2018)

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Synthesis and Structure–Activity Relationship Study of a New Series of Selective σ1 Receptor Ligands for the Treatment of Pain: 4‑Aminotriazoles

by Díaz, José Luis, Christmann, Ute, Fernández, Ariadna, Torrens, Antoni, Port, Adriana, Pascual, Rosalia, Álvarez, Inés, Burgueño, Javier, Monroy, Xavier, Montero, Ana, Balada, Ariadna, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2015)

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WLB-87848, a Selective σ 1 Receptor Agonist, with an Unusually Positioned NH Group as Positive Ionizable Moiety and Showing Neuroprotective Activity

by Christmann, Ute, Garriga, Lourdes, Llorente, Ana Virginia, Díaz, José Luis, Pascual, Rosalía, Bordas, Magda, Dordal, Albert, Porras, Mónica, Yeste, Sandra, Reinoso, Raquel F, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (13.06.2024)

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Comparison of Ligand-Based and Receptor-Based Virtual Screening of HIV Entry Inhibitors for the CXCR4 and CCR5 Receptors Using 3D Ligand Shape Matching and Ligand−Receptor Docking

by Pérez-Nueno, Violeta I, Ritchie, David W, Rabal, Obdulia, Pascual, Rosalia, Borrell, Jose I, Teixidó, Jordi
Published in Journal of chemical information and modeling (01.03.2008)

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4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ 1 Receptor Antagonists for the Treatment of Pain

by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Fernández, Begoña, Port, Adriana, Pascual, Rosalía, Monroy, Xavier, Vidal-Torres, Alba, Serafini, María-Teresa, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual mu-Opioid Receptor Agonists and sigma(1) Receptor Antagonists for the Treatment of Pain

by Garcia, Monica, Virgili, Marina, Alonso, Monica, Alegret, Caries, Fernandez, Begona, Port, Adriana, Pascual, Rosalia, Monroy, Xavier, Vidal-Torres, Alba, Serafini, Maria-Teresa, Miguel Vela, Jose, Almansa, Carmen
Published in Journal of medicinal chemistry (12.03.2020)

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Discovery of WLB-89462, a New Drug-like and Highly Selective s2 Receptor Ligand with Neuroprotective Properties

by Christmann, Ute, Diaz, Jose Luis, Pascual, Rosalia, Bordas, Magda, Alvarez, Ines, Monroy, Xavier, Porras, Monica, Yeste, Sandra, Reinoso, Raquel F., Merlos, Manuel, Vela, Jose Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (22.08.2023)

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Discovery of WLB-89462, a New Drug-like and Highly Selective σ 2 Receptor Ligand with Neuroprotective Properties

by Christmann, Ute, Díaz, José Luis, Pascual, Rosalia, Bordas, Magda, Álvarez, Inés, Monroy, Xavier, Porras, Mónica, Yeste, Sandra, Reinoso, Raquel F., Merlos, Manuel, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (14.09.2023)

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Pushing the Limits of Computational Structure-Based Drug Design with a Cryo-EM Structure: The Ca 2+ Channel α2δ-1 Subunit as a Test Case

by Kotev, Martin, Pascual, Rosalia, Almansa, Carmen, Guallar, Victor, Soliva, Robert
Published in Journal of chemical information and modeling (27.08.2018)

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Pushing the Limits of Computational Structure-Based Drug Design with a Cryo-EM Structure: The Ca2+ Channel α2δ‑1 Subunit as a Test Case

by Kotev, Martin, Pascual, Rosalia, Almansa, Carmen, Guallar, Victor, Soliva, Robert
Published in Journal of chemical information and modeling (27.08.2018)

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Pushing the Limits of Computational Structure-Based Drug Design with a Cryo-EM Structure: The Ca2+ Channel a2d-1 Subunit as a Test Case

by Kotev, Martin, Pascual, Rosalia, Almansa, Carmen, Guallar, Victor, Soliva, Robert
Published in Journal of chemical information and modeling (27.08.2018)

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Discovery of EST73502, a Dual mu-Opioid Receptor Agonist and sigma(1) Receptor Antagonist Clinical Candidate for the Treatment of Pain

by Garcia, Monica, Virgili, Marina, Alonso, Monica, Alegret, Carles, Farran, Joan, Fernandez, Begona, Bordas, Magda, Pascual, Rosalia, Burgueno, Javier, Vidal-Torres, Alba, Fernandez de Henestrosa, Antonio R., Ayet, Eva, Merlos, Manuel, Miguel Vela, Jose, Plata-Salaman, Carlos R., Almansa, Carmen
Published in Journal of medicinal chemistry (24.12.2020)

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Discovery of WLB-89462, a New Drug-like and Highly Selective σ2 Receptor Ligand with Neuroprotective Properties

by Christmann, Ute, Díaz, José Luis, Pascual, Rosalia, Bordas, Magda, Álvarez, Inés, Monroy, Xavier, Porras, Mónica, Yeste, Sandra, Reinoso, Raquel F., Merlos, Manuel, Vela, José Miguel, Almansa, Carmen
Published in Journal of medicinal chemistry (14.09.2023)

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Evaluation of log Po/w values of drugs from some molecular structure calculation software

by Pallicer, Juan M, Roses, Marti, Rafols, Clara, Bosch, Elisabeth, Pascual, Rosalia, Port, Adriana
Published in ADMET & DMPK (01.07.2014)

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Discovery of EST73502, a Dual μ‑Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain

by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Farran, Joan, Fernández, Begoña, Bordas, Magda, Pascual, Rosalia, Burgueño, Javier, Vidal-Torres, Alba, Fernández de Henestrosa, Antonio R, Ayet, Eva, Merlos, Manuel, Vela, Jose Miguel, Plata-Salamán, Carlos R, Almansa, Carmen
Published in Journal of medicinal chemistry (24.12.2020)

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