Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease
Pascoal, T A, Mathotaarachchi, S, Mohades, S, Benedet, A L, Chung, C-O, Shin, M, Wang, S, Beaudry, T, Kang, M S, Soucy, J-P, Labbe, A, Gauthier, S, Rosa-Neto, P
Published in Molecular psychiatry (01.02.2017)
Published in Molecular psychiatry (01.02.2017)
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Impact of the biological definition of Alzheimer's disease using amyloid, tau and neurodegeneration (ATN): what about the role of vascular changes, inflammation, Lewy body pathology?
Gauthier, S, Zhang, H, Ng, K P, Pascoal, T A, Rosa-Neto, P
Published in Translational neurodegeneration (31.05.2018)
Published in Translational neurodegeneration (31.05.2018)
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Neuroinflammation Biomarkers in the AT(N) Framework Across the Alzheimer's Disease Continuum
Bieger, A, Rocha, A, Bellaver, B, Machado, L, Da Ros, L, Borelli, W V, Therriault, J, Macedo, A C, Pascoal, T A, Gauthier, S, Rosa-Neto, P, Zimmer, E R
Published in The journal of prevention of Alzheimer's disease (2023)
Published in The journal of prevention of Alzheimer's disease (2023)
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Clinical Correlates of the PET-based Braak Staging Framework in Alzheimer's Disease
Macedo, A C, Durço, D F P A, Tissot, C, Therriault, J, Vilela de Faria, A O, Aumont, É, Servaes, S, Rahmouni, N, Fernandez-Arias, J, Wang, Y-T, Lussier, F Z, Bieger, A, Zimmer, E R, Pascoal, T A, Gauthier, S, Rosa-Neto, P
Published in The journal of prevention of Alzheimer's disease (2024)
Published in The journal of prevention of Alzheimer's disease (2024)
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Staging of Alzheimer?s disease: past, present and future perspectives
Therriault, J., Zimmer, E. R., Lessa Benedet, Andréa, Pascoal, T. A., Gauthier, S., Rosa-Neto, P.
Published in Trends in molecular medicine (01.09.2022)
Published in Trends in molecular medicine (01.09.2022)
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Journal Article
Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility
Karikari, Thomas K, Ashton, Nicholas J, Brinkmalm, Gunnar, Brum, Wagner S, Benedet, Andréa L, Montoliu-Gaya, Laia, Lantero-Rodriguez, Juan, Pascoal, Tharick Ali, Suárez-Calvet, Marc, Rosa-Neto, Pedro, Blennow, Kaj, Zetterberg, Henrik
Published in Nature reviews. Neurology (01.07.2022)
Published in Nature reviews. Neurology (01.07.2022)
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Journal Article
Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease
Bellaver, Bruna, Povala, Guilherme, Ferreira, Pamela C L, Ferrari-Souza, João Pedro, Leffa, Douglas T, Lussier, Firoza Z, Benedet, Andréa L, Ashton, Nicholas J, Triana-Baltzer, Gallen, Kolb, Hartmuth C, Tissot, Cécile, Therriault, Joseph, Servaes, Stijn, Stevenson, Jenna, Rahmouni, Nesrine, Lopez, Oscar L, Tudorascu, Dana L, Villemagne, Victor L, Ikonomovic, Milos D, Gauthier, Serge, Zimmer, Eduardo R, Zetterberg, Henrik, Blennow, Kaj, Aizenstein, Howard J, Klunk, William E, Snitz, Beth E, Maki, Pauline, Thurston, Rebecca C, Cohen, Ann D, Ganguli, Mary, Karikari, Thomas K, Rosa-Neto, Pedro, Pascoal, Tharick A
Published in Nature medicine (01.07.2023)
Published in Nature medicine (01.07.2023)
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Journal Article
Determining Amyloid-β Positivity Using 18F-AZD4694 PET Imaging
Therriault, Joseph, Benedet, Andrea L, Pascoal, Tharick A, Savard, Melissa, Ashton, Nicholas J, Chamoun, Mira, Tissot, Cecile, Lussier, Firoza, Kang, Min Su, Bezgin, Gleb, Wang, Tina, Fernandes-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Zetterberg, Henrik, Blennow, Kaj, Saha-Chaudhuri, Paramita, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro
Published in The Journal of nuclear medicine (1978) (01.02.2021)
Published in The Journal of nuclear medicine (1978) (01.02.2021)
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Journal Article
Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer's disease
Ferrari-Souza, João Pedro, Ferreira, Pâmela C L, Bellaver, Bruna, Tissot, Cécile, Wang, Yi-Ting, Leffa, Douglas T, Brum, Wagner S, Benedet, Andréa L, Ashton, Nicholas J, De Bastiani, Marco Antônio, Rocha, Andréia, Therriault, Joseph, Lussier, Firoza Z, Chamoun, Mira, Servaes, Stijn, Bezgin, Gleb, Kang, Min Su, Stevenson, Jenna, Rahmouni, Nesrine, Pallen, Vanessa, Poltronetti, Nina Margherita, Klunk, William E, Tudorascu, Dana L, Cohen, Ann D, Villemagne, Victor L, Gauthier, Serge, Blennow, Kaj, Zetterberg, Henrik, Souza, Diogo O, Karikari, Thomas K, Zimmer, Eduardo R, Rosa-Neto, Pedro, Pascoal, Tharick A
Published in Molecular psychiatry (01.11.2022)
Published in Molecular psychiatry (01.11.2022)
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Journal Article
Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages
Pascoal, Tharick A, Benedet, Andrea L, Tudorascu, Dana L, Therriault, Joseph, Mathotaarachchi, Sulantha, Savard, Melissa, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Kang, Min Su, Stevenson, Jenna, Massarweh, Gassan, Guiot, Marie-Christine, Soucy, Jean-Paul, Gauthier, Serge, Rosa-Neto, Pedro
Published in Brain (London, England : 1878) (16.12.2021)
Published in Brain (London, England : 1878) (16.12.2021)
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Journal Article
Plasma biomarkers identify older adults at risk of Alzheimer's disease and related dementias in a real-world population-based cohort
Ferreira, Pamela C L, Zhang, Yingjin, Snitz, Beth, Chang, Chung-Chou H, Bellaver, Bruna, Jacobsen, Erin, Kamboh, M Ilyas, Zetterberg, Henrik, Blennow, Kaj, Pascoal, Tharick A, Villemagne, Victor L, Ganguli, Mary, Karikari, Thomas K
Published in Alzheimer's & dementia (01.10.2023)
Published in Alzheimer's & dementia (01.10.2023)
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Journal Article
Biomarker modeling of Alzheimer's disease using PET-based Braak staging
Therriault, Joseph, Pascoal, Tharick A, Lussier, Firoza Z, Tissot, Cécile, Chamoun, Mira, Bezgin, Gleb, Servaes, Stijn, Benedet, Andrea L, Ashton, Nicholas J, Karikari, Thomas K, Lantero-Rodriguez, Juan, Kunach, Peter, Wang, Yi-Ting, Fernandez-Arias, Jaime, Massarweh, Gassan, Vitali, Paolo, Soucy, Jean-Paul, Saha-Chaudhuri, Paramita, Blennow, Kaj, Zetterberg, Henrik, Gauthier, Serge, Rosa-Neto, Pedro
Published in Nature aging (01.06.2022)
Published in Nature aging (01.06.2022)
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Journal Article
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer's disease
Therriault, Joseph, Servaes, Stijn, Tissot, Cécile, Rahmouni, Nesrine, Ashton, Nicholas J, Benedet, Andréa Lessa, Karikari, Thomas K, Macedo, Arthur C, Lussier, Firoza Z, Stevenson, Jenna, Wang, Yi-Ting, Fernandez-Arias, Jaime, Stevenson, Alyssa, Socualaya, Kely Quispialaya, Haeger, Arlette, Nazneen, Tahnia, Aumont, Étienne, Hosseini, Ali, Rej, Soham, Vitali, Paolo, Triana-Baltzer, Gallen, Kolb, Hartmuth C, Soucy, Jean-Paul, Pascoal, Tharick A, Gauthier, Serge, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro
Published in Alzheimer's & dementia (01.11.2023)
Published in Alzheimer's & dementia (01.11.2023)
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Journal Article
Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease
Kang, Min Su, Aliaga, Arturo Aliaga, Shin, Monica, Mathotaarachchi, Sulantha, Benedet, Andrea L, Pascoal, Tharick A, Therriault, Joseph, Chamoun, Mira, Savard, Melissa, Devenyi, Gabriel A, Mathieu, Axel, Chakravarty, M Mallar, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Soucy, Jean-Paul, Cuello, A Claudio, Massarweh, Gassan, Gauthier, Serge, Rosa-Neto, Pedro
Published in Molecular psychiatry (01.10.2021)
Published in Molecular psychiatry (01.10.2021)
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Journal Article
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older adults
Leffa, Douglas T, Ferrari-Souza, João Pedro, Bellaver, Bruna, Tissot, Cécile, Ferreira, Pamela C L, Brum, Wagner S, Caye, Arthur, Lord, Jodie, Proitsi, Petroula, Martins-Silva, Thais, Tovo-Rodrigues, Luciana, Tudorascu, Dana L, Villemagne, Victor L, Cohen, Ann D, Lopez, Oscar L, Klunk, William E, Karikari, Thomas K, Rosa-Neto, Pedro, Zimmer, Eduardo R, Molina, Brooke S G, Rohde, Luis Augusto, Pascoal, Tharick A
Published in Molecular psychiatry (01.03.2023)
Published in Molecular psychiatry (01.03.2023)
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Journal Article
Blood‐brain barrier integrity impacts the use of plasma amyloid‐β as a proxy of brain amyloid‐β pathology
Bellaver, Bruna, Puig‐Pijoan, Albert, Ferrari‐Souza, João Pedro, Leffa, Douglas T., Lussier, Firoza Z., Ferreira, Pamela C. L., Tissot, Cécile, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L., Ashton, Nicholas J., Servaes, Stijn, Chamoun, Mira, Stevenson, Jenna, Rahmouni, Nesrine, Vermeiren, Marie, Macedo, Arthur C., Fernández‐Lebrero, Aida, García‐Escobar, Greta, Navalpotro‐Gómez, Irene, Lopez, Oscar, Tudorascu, Dana L., Cohen, Ann, Villemagne, Victor L., Klunk, William E., Gauthier, Serge, Zimmer, Eduardo R., Karikari, Thomas K., Blennow, Kaj, Zetterberg, Henrik, Suárez‐Calvet, Marc, Rosa‐Neto, Pedro, Pascoal, Tharick A.
Published in Alzheimer's & dementia (01.09.2023)
Published in Alzheimer's & dementia (01.09.2023)
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Journal Article
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of 18F MK6240 Tau PET in Target Regions
Tissot, C., Servaes, S., Lussier, F. Z., Ferrai-Souza, J. P., Therriault, J., Ferreirat, P. C., Bezgin, G., Bellaver, B., Leffa, D. T., Mathotaarachchi, S. S., Chamoun, M., Stevenson, J., Rahmouni, N., Kang, M. S., Pallen, V., Margherita-Poltronetti, N., Wang, Y. T., Fernandez-Arias, J., Lessa Benedet, Andréa, Zimmer, E. R., Soucy, J. P., Tudorascu, D. L., Cohen, A. D., Sharp, M., Gauthier, S., Massarweh, G., Lopresti, B., Klunk, W. E., Baker, S. L., Villemagne, V. L., Rosa-Neto, P., Pascoal, T. A.
Published in The Journal of nuclear medicine (1978) (2023)
Published in The Journal of nuclear medicine (1978) (2023)
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Journal Article
Plasma and CSF concentrations of N‐terminal tau fragments associate with in vivo neurofibrillary tangle burden
Lantero‐Rodriguez, Juan, Tissot, Cécile, Snellman, Anniina, Servaes, Stijn, Benedet, Andrea L., Rahmouni, Nesrine, Montoliu‐Gaya, Laia, Therriault, Joseph, Brum, Wagner S., Stevenson, Jenna, Lussier, Firoza Z., Bezgin, Gleb, Macedo, Arthur C., Chamoun, Mira, Mathotaarachi, Sulantha S., Pascoal, Tharick A., Ashton, Nicholas J., Zetterberg, Henrik, Neto, Pedro Rosa, Blennow, Kaj
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Journal Article
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials
Ferreira, Pamela C L, Ferrari-Souza, João Pedro, Tissot, Cécile, Bellaver, Bruna, Leffa, Douglas T, Lussier, Firoza, Povala, Guilherme, Therriault, Joseph, Benedet, Andréa L, Ashton, Nicholas J, Cohen, Ann D, Lopez, Oscar L, Tudorascu, Dana L, Klunk, William E, Soucy, Jean-Paul, Gauthier, Serge, Villemagne, Victor, Zetterberg, Henrik, Blennow, Kaj, Rosa-Neto, Pedro, Zimmer, Eduardo R, Karikari, Thomas K, Pascoal, Tharick A
Published in Neurology (04.07.2023)
Published in Neurology (04.07.2023)
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Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic
Kang, Min Su, Shin, Monica, Ottoy, Julie, Aliaga, Arturo Aliaga, Mathotaarachchi, Sulantha, Quispialaya, Kely, Pascoal, Tharick A, Collins, D Louis, Chakravarty, M. Mallar, Mathieu, Axel, Sandelius, Åsa, Blennow, Kaj, Zetterberg, Henrik, Massarweh, Gassan, Soucy, Jean-Paul, Cuello, A Claudio, Gauthier, Serge, Waterston, Michael, Yoganathan, Nathan, Lessard, Etienne, Haqqani, Arsalan, Rennie, Kerry, Stanimirovic, Danica, Chakravarthy, Balu, Rosa-Neto, Pedro
Published in Journal of cerebral blood flow and metabolism (01.05.2022)
Published in Journal of cerebral blood flow and metabolism (01.05.2022)
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