Robust isolation protocol for mouse leukocytes from blood and liver resident cells for immunology research
De Pooter, Dorien, De Clerck, Ben, Dockx, Koen, De Santis, Domenica, Sauviller, Sarah, Dehertogh, Pascale, Beyens, Matthias, Bergiers, Isabelle, Nájera, Isabel, Van Gulck, Ellen, Conceição-Neto, Nádia, Pierson, Wim
Published in PloS one (22.08.2024)
Published in PloS one (22.08.2024)
Get full text
Journal Article
In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435
LENZ, Oliver, VERBINNEN, Thierry, VERMEIREN, Katrien, IVENS, Tania, RABOISSON, Pierre, EDLUND, Michael, STORM, Susan, VRANG, Lotta, DE KOCK, Herman, FANNING, Gregory C, SIMMEN, Kenneth A, LIN, Tse-I, VIJGEN, Leen, CUMMINGS, Maxwell D, LINDBERG, Jimmy, MARTIN BERKE, Jan, DEHERTOGH, Pascale, FRANSEN, Els, SCHOLLIERS, Annick
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
Published in Antimicrobial Agents and Chemotherapy (01.05.2010)
Get full text
Journal Article
Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories
Hayeshi, Rose, Hilgendorf, Constanze, Artursson, Per, Augustijns, Patrick, Brodin, Birger, Dehertogh, Pascale, Fisher, Karen, Fossati, Lina, Hovenkamp, Egbert, Korjamo, Timo, Masungi, Chantal, Maubon, Nathalie, Mols, Raf, Müllertz, Anette, Mönkkönen, Jukka, O’Driscoll, Caitriona, Oppers-Tiemissen, H.M., Ragnarsson, Eva G.E., Rooseboom, Martijn, Ungell, Anna-Lena
Published in European journal of pharmaceutical sciences (18.12.2008)
Published in European journal of pharmaceutical sciences (18.12.2008)
Get full text
Journal Article
TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage
DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Published in Antimicrobial Agents and Chemotherapy (01.09.2012)
Get full text
Journal Article
Indolopyridones Inhibit Human Immunodeficiency Virus Reverse Transcriptase with a Novel Mechanism of Action
JOCHMANS, Dirk, DEVAL, Jérome, EHTESHAMI, Maryam, WIGERINCK, Piet, GÖTTE, Matthias, HERTOGS, Kurt, KESTELEYN, Bart, VAN MARCK, Herwig, BETTENS, Eva, DE BAERE, Inky, DEHERTOGH, Pascale, IVENS, Tania, VAN GINDEREN, Marcia, VAN SCHOUBROECK, Bertrand
Published in Journal of Virology (01.12.2006)
Published in Journal of Virology (01.12.2006)
Get full text
Journal Article
1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors
NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Get full text
Journal Article
1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus
NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver
Published in Journal of Virology (01.03.2010)
Published in Journal of Virology (01.03.2010)
Get full text
Journal Article
Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
MARTIN BERKE, Jan, VIJGEN, Leen, VAN DEN EYNDE, Christel, LECLERCQ, Laurent, JONCKERS, Tim H. M, RABOISSON, Pierre, NILSSON, Magnus, SAMUELSSON, Bertil, ROSENQUIST, Asa, FANNING, Gregory C, LIN, Tse-I, LACHAU-DURAND, Sophie, POWDRILL, Megan H, RAWE, Svea, SJUVARSSON, Elena, ERIKSSON, Staffan, GÖTTE, Matthias, FRANSEN, Els, DEHERTOGH, Pascale
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Get full text
Journal Article
A Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutational Pattern Confers Phenotypic Lamivudine Resistance in the Absence of Mutation 184V
HERTOGS, K, BLOOR, S, MILLER, V, LARDER, B. A, DE VROEY, V, VAN DEN EYNDE, C, DEHERTOGH, P, VAN CAUWENBERGE, A, STÜRMER, M, ALCORN, T, WEGNER, S, VAN HOUTTE, M
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
Published in Antimicrobial Agents and Chemotherapy (01.03.2000)
Get full text
Journal Article
Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus
Berke, Jan Martin, Dehertogh, Pascale, Vergauwen, Karen, Van Damme, Ellen, Mostmans, Wendy, Vandyck, Koen, Pauwels, Frederik
Published in Antimicrobial agents and chemotherapy (01.08.2017)
Published in Antimicrobial agents and chemotherapy (01.08.2017)
Get full text
Journal Article
Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379
Berke, Jan Martin, Dehertogh, Pascale, Vergauwen, Karen, Mostmans, Wendy, Vandyck, Koen, Raboisson, Pierre, Pauwels, Frederik
Published in Antimicrobial agents and chemotherapy (21.04.2020)
Published in Antimicrobial agents and chemotherapy (21.04.2020)
Get full text
Journal Article
Anti-HBV activity of the HBV capsid assembly modulator JNJ-56136379 across full-length genotype A–H clinical isolates and core site-directed mutants in vitro
Verbinnen, Thierry, Tan, Ying, Wang, Gengyan, Dehertogh, Pascale, Vergauwen, Karen, Neefs, Jean-Marc, Jacoby, Edgar, Lenz, Oliver, Berke, Jan Martin
Published in Journal of antimicrobial chemotherapy (01.09.2020)
Published in Journal of antimicrobial chemotherapy (01.09.2020)
Get full text
Journal Article
Synthesis and Evaluation of N‑Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV)
Vandyck, Koen, Rombouts, Geert, Stoops, Bart, Tahri, Abdellah, Vos, Ann, Verschueren, Wim, Wu, Yiming, Yang, Jingmei, Hou, Fuliang, Huang, Bing, Vergauwen, Karen, Dehertogh, Pascale, Berke, Jan Martin, Raboisson, Pierre
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
Get full text
Journal Article
Antiviral profiling of the capsid assembly modulator BAY41-4109 on full-length HBV genotype A-H clinical isolates and core site-directed mutants in vitro
Berke, Jan Martin, Tan, Ying, Verbinnen, Thierry, Dehertogh, Pascale, Vergauwen, Karen, Vos, Ann, Lenz, Oliver, Pauwels, Frederik
Published in Antiviral research (01.08.2017)
Published in Antiviral research (01.08.2017)
Get full text
Journal Article
Robust isolation protocol for mouse leukocytes from blood and liver resident cells for immunology research
Dorien De Pooter, Ben De Clerck, Koen Dockx, Domenica De Santis, Sarah Sauviller, Pascale Dehertogh, Matthias Beyens, Isabelle Bergiers, Isabel Nájera, Ellen Van Gulck, Nádia Conceição-Neto, Wim Pierson
Published in PloS one (01.01.2024)
Published in PloS one (01.01.2024)
Get full text
Journal Article
Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Nyanguile, Origène, Simmen, Kenny, Van Remoortere, Pieter, Raboisson, Pierre, Vendeville, Sandrine
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties
Cummings, Maxwell D., Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre, Vendeville, Sandrine
Published in Angewandte Chemie International Edition (07.05.2012)
Published in Angewandte Chemie International Edition (07.05.2012)
Get full text
Journal Article
Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055
Vendeville, Sandrine, Lin, Tse-I., Hu, Lili, Tahri, Abdellah, McGowan, David, Cummings, Maxwell D., Amssoms, Katie, Canard, Maxime, Last, Stefaan, Van den Steen, Iris, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Fanning, Gregory, Van Emelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Get full text
Journal Article
Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series
McGowan, David, Vendeville, Sandrine, Lin, Tse-I, Tahri, Abdellah, Hu, Lili, Cummings, Maxwell D., Amssoms, Katie, Berke, Jan Martin, Canard, Maxime, Cleiren, Erna, Dehertogh, Pascale, Last, Stefaan, Fransen, Els, Van Der Helm, Elisabeth, Van den Steen, Iris, Vijgen, Leen, Rouan, Marie-Claude, Fanning, Gregory, Nyanguile, Origène, Van Emelen, Kristof, Simmen, Kenneth, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Get full text
Journal Article
Structure-Based Macrocyclization Yields HepatitisC Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties
Cummings, Maxwell D, Lin, Tse-I, Hu, Lili, Tahri, Abdellah, McGowan, David, Amssoms, Katie, Last, Stefaan, Devogelaere, Benoit, Rouan, Marie-Claude, Vijgen, Leen, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, vanderHelm, Liesbet, Fanning, Gregory, VanEmelen, Kristof, Nyanguile, Origène, Simmen, Kenny, Raboisson, Pierre, Vendeville, Sandrine
Published in Angewandte Chemie International Edition (07.05.2012)
Published in Angewandte Chemie International Edition (07.05.2012)
Get full text
Journal Article