Probabilistic fine-mapping of transcriptome-wide association studies
Mancuso, Nicholas, Freund, Malika K., Johnson, Ruth, Shi, Huwenbo, Kichaev, Gleb, Gusev, Alexander, Pasaniuc, Bogdan
Published in Nature genetics (01.04.2019)
Published in Nature genetics (01.04.2019)
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Leveraging Polygenic Functional Enrichment to Improve GWAS Power
Kichaev, Gleb, Bhatia, Gaurav, Loh, Po-Ru, Gazal, Steven, Burch, Kathryn, Freund, Malika K., Schoech, Armin, Pasaniuc, Bogdan, Price, Alkes L.
Published in American journal of human genetics (03.01.2019)
Published in American journal of human genetics (03.01.2019)
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Colocalization of GWAS and eQTL Signals Detects Target Genes
Hormozdiari, Farhad, van de Bunt, Martijn, Segrè, Ayellet V., Li, Xiao, Joo, Jong Wha J., Bilow, Michael, Sul, Jae Hoon, Sankararaman, Sriram, Pasaniuc, Bogdan, Eskin, Eleazar
Published in American journal of human genetics (01.12.2016)
Published in American journal of human genetics (01.12.2016)
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Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms
Walker, Rebecca L., Ramaswami, Gokul, Hartl, Christopher, Mancuso, Nicholas, Gandal, Michael J., de la Torre-Ubieta, Luis, Pasaniuc, Bogdan, Stein, Jason L., Geschwind, Daniel H.
Published in Cell (17.10.2019)
Published in Cell (17.10.2019)
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A Bayesian framework for multiple trait colocalization from summary association statistics
Giambartolomei, Claudia, Zhenli Liu, Jimmy, Zhang, Wen, Hauberg, Mads, Shi, Huwenbo, Boocock, James, Pickrell, Joe, Jaffe, Andrew E, Pasaniuc, Bogdan, Roussos, Panos
Published in Bioinformatics (01.08.2018)
Published in Bioinformatics (01.08.2018)
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Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification
Ding, Yi, Hou, Kangcheng, Burch, Kathryn S., Lapinska, Sandra, Privé, Florian, Vilhjálmsson, Bjarni, Sankararaman, Sriram, Pasaniuc, Bogdan
Published in Nature genetics (01.01.2022)
Published in Nature genetics (01.01.2022)
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Efficient variance components analysis across millions of genomes
Pazokitoroudi, Ali, Wu, Yue, Burch, Kathryn S., Hou, Kangcheng, Zhou, Aaron, Pasaniuc, Bogdan, Sankararaman, Sriram
Published in Nature communications (11.08.2020)
Published in Nature communications (11.08.2020)
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Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization
Pathak, Gita A., Singh, Kritika, Miller-Fleming, Tyne W., Wendt, Frank R., Ehsan, Nava, Hou, Kangcheng, Johnson, Ruth, Lu, Zeyun, Gopalan, Shyamalika, Yengo, Loic, Mohammadi, Pejman, Pasaniuc, Bogdan, Polimanti, Renato, Davis, Lea K., Mancuso, Nicholas
Published in Nature communications (27.07.2021)
Published in Nature communications (27.07.2021)
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Journal Article
Integrating functional data to prioritize causal variants in statistical fine-mapping studies
Kichaev, Gleb, Yang, Wen-Yun, Lindstrom, Sara, Hormozdiari, Farhad, Eskin, Eleazar, Price, Alkes L, Kraft, Peter, Pasaniuc, Bogdan
Published in PLoS genetics (01.10.2014)
Published in PLoS genetics (01.10.2014)
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Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies
Feng, Helian, Mancuso, Nicholas, Gusev, Alexander, Majumdar, Arunabha, Major, Megan, Pasaniuc, Bogdan, Kraft, Peter
Published in PLoS genetics (08.04.2021)
Published in PLoS genetics (08.04.2021)
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Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis
Mandric, Igor, Schwarz, Tommer, Majumdar, Arunabha, Hou, Kangcheng, Briscoe, Leah, Perez, Richard, Subramaniam, Meena, Hafemeister, Christoph, Satija, Rahul, Ye, Chun Jimmie, Pasaniuc, Bogdan, Halperin, Eran
Published in Nature communications (30.10.2020)
Published in Nature communications (30.10.2020)
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Improved methods for multi-trait fine mapping of pleiotropic risk loci
Kichaev, Gleb, Roytman, Megan, Johnson, Ruth, Eskin, Eleazar, Lindström, Sara, Kraft, Peter, Pasaniuc, Bogdan
Published in Bioinformatics (Oxford, England) (15.01.2017)
Published in Bioinformatics (Oxford, England) (15.01.2017)
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Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
Choi, Jiyeon, Zhang, Tongwu, Vu, Andrew, Ablain, Julien, Makowski, Matthew M., Colli, Leandro M., Xu, Mai, Hennessey, Rebecca C., Yin, Jinhu, Rothschild, Harriet, Gräwe, Cathrin, Kovacs, Michael A., Funderburk, Karen M., Brossard, Myriam, Taylor, John, Pasaniuc, Bogdan, Chari, Raj, Chanock, Stephen J., Hoggart, Clive J., Demenais, Florence, Barrett, Jennifer H., Law, Matthew H., Iles, Mark M., Yu, Kai, Vermeulen, Michiel, Zon, Leonard I., Brown, Kevin M.
Published in Nature communications (01.06.2020)
Published in Nature communications (01.06.2020)
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Journal Article
Contrasting the Genetic Architecture of 30 Complex Traits from Summary Association Data
Shi, Huwenbo, Kichaev, Gleb, Pasaniuc, Bogdan
Published in American journal of human genetics (07.07.2016)
Published in American journal of human genetics (07.07.2016)
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Journal Article
Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data
Shi, Huwenbo, Burch, Kathryn S., Johnson, Ruth, Freund, Malika K., Kichaev, Gleb, Mancuso, Nicholas, Manuel, Astrid M., Dong, Natalie, Pasaniuc, Bogdan
Published in American journal of human genetics (04.06.2020)
Published in American journal of human genetics (04.06.2020)
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Journal Article
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights
Gusev, Alexander, Mancuso, Nicholas, Won, Hyejung, Kousi, Maria, Finucane, Hilary K., Reshef, Yakir, Song, Lingyun, Safi, Alexias, McCarroll, Steven, Neale, Benjamin M., Ophoff, Roel A., O’Donovan, Michael C., Crawford, Gregory E., Geschwind, Daniel H., Katsanis, Nicholas, Sullivan, Patrick F., Pasaniuc, Bogdan, Price, Alkes L.
Published in Nature genetics (01.04.2018)
Published in Nature genetics (01.04.2018)
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Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD
Gandal, Michael J., Haney, Jillian R., Wamsley, Brie, Yap, Chloe X., Parhami, Sepideh, Emani, Prashant S., Chang, Nathan, Chen, George T., Hoftman, Gil D., de Alba, Diego, Ramaswami, Gokul, Hartl, Christopher L., Bhattacharya, Arjun, Luo, Chongyuan, Jin, Ting, Wang, Daifeng, Kawaguchi, Riki, Quintero, Diana, Ou, Jing, Wu, Ye Emily, Parikshak, Neelroop N., Swarup, Vivek, Belgard, T. Grant, Gerstein, Mark, Pasaniuc, Bogdan, Geschwind, Daniel H.
Published in Nature (London) (17.11.2022)
Published in Nature (London) (17.11.2022)
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A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes
Majumdar, Arunabha, Patel, Preksha, Pasaniuc, Bogdan, Ophoff, Roel A
Published in European journal of human genetics : EJHG (01.05.2022)
Published in European journal of human genetics : EJHG (01.05.2022)
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