Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review
Vertzoni, Maria, Augustijns, Patrick, Grimm, Michael, Koziolek, Mirko, Lemmens, Glenn, Parrott, Neil, Pentafragka, Christina, Reppas, Christos, Rubbens, Jari, Van Den Αbeele, Jens, Vanuytsel, Tim, Weitschies, Werner, Wilson, Clive G.
Published in European journal of pharmaceutical sciences (15.06.2019)
Published in European journal of pharmaceutical sciences (15.06.2019)
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Journal Article
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
Guo, Yingying, Chu, Xiaoyan, Parrott, Neil J, Brouwer, Kim L R, Hsu, Vicky, Nagar, Swati, Matsson, Pär, Sharma, Pradeep, Snoeys, Jan, Sugiyama, Yuichi, Tatosian, Daniel, Unadkat, Jashvant D, Huang, Shiew-Mei, Galetin, Aleksandra
Published in Clinical pharmacology and therapeutics (01.11.2018)
Published in Clinical pharmacology and therapeutics (01.11.2018)
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Journal Article
The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group
Koziolek, Mirko, Alcaro, Stefano, Augustijns, Patrick, Basit, Abdul W., Grimm, Michael, Hens, Bart, Hoad, Caroline L., Jedamzik, Philipp, Madla, Christine M., Maliepaard, Marc, Marciani, Luca, Maruca, Annalisa, Parrott, Neil, Pávek, Petr, Porter, Christopher J.H., Reppas, Christos, van Riet-Nales, Diana, Rubbens, Jari, Statelova, Marina, Trevaskis, Natalie L., Valentová, Kateřina, Vertzoni, Maria, Čepo, Dubravka Vitali, Corsetti, Maura
Published in European journal of pharmaceutical sciences (15.06.2019)
Published in European journal of pharmaceutical sciences (15.06.2019)
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Journal Article
Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
Bahnasawy, Salma M., Parrott, Neil J., Gijsen, Matthias, Spriet, Isabel, Friberg, Lena E., Nielsen, Elisabet I.
Published in International journal of antimicrobial agents (01.12.2024)
Published in International journal of antimicrobial agents (01.12.2024)
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Journal Article
Physiologically‐Based Pharmacokinetic Modeling in Renal and Hepatic Impairment Populations: A Pharmaceutical Industry Perspective
Heimbach, Tycho, Chen, Yuan, Chen, Jun, Dixit, Vaishali, Parrott, Neil, Peters, Sheila Annie, Poggesi, Italo, Sharma, Pradeep, Snoeys, Jan, Shebley, Mohamad, Tai, Guoying, Tse, Susanna, Upreti, Vijay V., Wang, Ying‐Hong, Tsai, Alice, Xia, Binfeng, Zheng, Ming, Zhu, Andy Z.X., Hall, Stephen
Published in Clinical pharmacology and therapeutics (01.08.2021)
Published in Clinical pharmacology and therapeutics (01.08.2021)
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Journal Article
Perspectives from the Innovation and Quality Consortium Induction Working Group on Factors Impacting Clinical Drug-Drug Interactions Resulting from Induction: Focus on Cytochrome 3A Substrates
Ramsden, Diane, Fung, Conrad, Hariparsad, Niresh, Kenny, Jane R, Mohutsky, Michael, Parrott, Neil J, Robertson, Sarah, Tweedie, Donald J
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling
Kratochwil, Nicole A., Meille, Christophe, Fowler, Stephen, Klammers, Florian, Ekiciler, Aynur, Molitor, Birgit, Simon, Sandrine, Walter, Isabelle, McGinnis, Claudia, Walther, Johanna, Leonard, Brian, Triyatni, Miriam, Javanbakht, Hassan, Funk, Christoph, Schuler, Franz, Lavé, Thierry, Parrott, Neil J.
Published in The AAPS journal (01.03.2017)
Published in The AAPS journal (01.03.2017)
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Journal Article
Mechanistic Population Pharmacokinetic Model of Oseltamivir and Oseltamivir Carboxylate Accounting for Physiological Changes to Predict Exposures in Neonates and Infants
Gibiansky, Leonid, Ravva, Patanjali, Parrott, Neil J., Bhardwaj, Rajinder, Zwanziger, Elke, Grimsey, Paul, Clinch, Barry, Sturm, Stefan
Published in Clinical pharmacology and therapeutics (01.07.2020)
Published in Clinical pharmacology and therapeutics (01.07.2020)
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Journal Article
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
Riedmaier, Arian Emami, DeMent, Kevin, Huckle, James, Bransford, Phil, Stillhart, Cordula, Lloyd, Richard, Alluri, Ravindra, Basu, Sumit, Chen, Yuan, Dhamankar, Varsha, Dodd, Stephanie, Kulkarni, Priyanka, Olivares-Morales, Andrés, Peng, Chi-Chi, Pepin, Xavier, Ren, Xiaojun, Tran, Thuy, Tistaert, Christophe, Heimbach, Tycho, Kesisoglou, Filippos, Wagner, Christian, Parrott, Neil
Published in The AAPS journal (27.09.2020)
Published in The AAPS journal (27.09.2020)
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Journal Article
Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry
Badée, Justine, Qiu, Nahong, Parrott, Neil, Collier, Abby C, Schmidt, Stephan, Fowler, Stephen
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Journal Article
Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs
Kristoffersson, Anders N., David-Pierson, Pascale, Parrott, Neil J., Kuhlmann, Olaf, Lave, Thierry, Friberg, Lena E., Nielsen, Elisabet I.
Published in Pharmaceutical research (01.05.2016)
Published in Pharmaceutical research (01.05.2016)
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Journal Article
Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state
Arndt, Marcel, Chokshi, Hitesh, Tang, Kin, Parrott, Neil J., Reppas, Christos, Dressman, Jennifer B.
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2013)
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2013)
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Journal Article
Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound, Basmisanil, Through Absorption Modelling and Dissolution Testing
Stillhart, Cordula, Parrott, Neil J., Lindenberg, Marc, Chalus, Pascal, Bentley, Darren, Szepes, Anikó
Published in The AAPS journal (01.05.2017)
Published in The AAPS journal (01.05.2017)
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Journal Article
Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach
Pepin, Xavier J. H., Huckle, James E., Alluri, Ravindra V., Basu, Sumit, Dodd, Stephanie, Parrott, Neil, Emami Riedmaier, Arian
Published in The AAPS journal (04.01.2021)
Published in The AAPS journal (04.01.2021)
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Journal Article
Evaluation of the potential impact on pharmacokinetics of various cytochrome P450 substrates of increasing IL‐6 levels following administration of the T‐cell bispecific engager glofitamab
Djebli, Nassim, Parrott, Neil, Jaminion, Felix, O'Jeanson, Amaury, Guerini, Elena, Carlile, David
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
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Journal Article
Development and application of neonatal physiology‐based pharmacokinetic models of amikacin and fosfomycin to assess pharmacodynamic target attainment
Darlow, Christopher A., Parrott, Neil, Peck, Richard W., Hope, William
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
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Journal Article
Importance of target-mediated drug disposition for small molecules
Smith, Dennis A., van Waterschoot, Robert A.B., Parrott, Neil J., Olivares-Morales, Andrés, Lavé, Thierry, Rowland, Malcolm
Published in Drug discovery today (01.12.2018)
Published in Drug discovery today (01.12.2018)
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Journal Article