Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
Chaidos, Aristeidis, Caputo, Valentina, Gouvedenou, Katerina, Liu, Binbin, Marigo, Ilaria, Chaudhry, Mohammed Suhail, Rotolo, Antonia, Tough, David F., Smithers, Nicholas N., Bassil, Anna K., Chapman, Trevor D., Harker, Nicola R., Barbash, Olena, Tummino, Peter, Al-Mahdi, Niam, Haynes, Andrea C., Cutler, Leanne, Le, BaoChau, Rahemtulla, Amin, Roberts, Irene, Kleijnen, Maurits, Witherington, Jason J., Parr, Nigel J., Prinjha, Rab K., Karadimitris, Anastasios
Published in Blood (30.01.2014)
Published in Blood (30.01.2014)
Get full text
Journal Article
Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Bandukwala, Hozefa S, Gagnon, John, Togher, Susan, Greenbaum, Jason A, Lamperti, Edward D, Parr, Nigel J, Molesworth, Amy M. H, Smithers, Nicholas, Lee, Kevin, Witherington, Jason, Tough, David F, Prinjha, Rab K, Peters, Bjoern, Rao, Anjana
Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
Get full text
Journal Article
The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes
Atkinson, Stephen J., Soden, Peter E., Angell, Davina C., Bantscheff, Marcus, Chung, Chun-wa, Giblin, Kathryn A., Smithers, Nicholas, Furze, Rebecca C., Gordon, Laurie, Drewes, Gerard, Rioja, Inmaculada, Witherington, Jason, Parr, Nigel J., Prinjha, Rab K.
Published in MedChemComm (2014)
Published in MedChemComm (2014)
Get full text
Journal Article
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease
Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
Get full text
Journal Article
Long‐term changes in bone mineral density and predicted fracture risk in patients receiving androgen‐deprivation therapy for prostate cancer, with stratification of treatment based on presenting values
Wadhwa, Vivek K., Weston, Robin, Mistry, Rahul, Parr, Nigel J.
Published in BJU international (01.09.2009)
Published in BJU international (01.09.2009)
Get full text
Journal Article
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
Piha-Paul, Sarina A, Hann, Christine L, French, Christopher A, Cousin, Sophie, Braña, Irene, Cassier, Phillippe A, Moreno, Victor, de Bono, Johann S, Harward, Sara Duckworth, Ferron-Brady, Geraldine, Barbash, Olena, Wyce, Anastasia, Wu, Yuehui, Horner, Thierry, Annan, Meg, Parr, Nigel J, Prinjha, Rabinder K, Carpenter, Christopher L, Hilton, John, Hong, David S, Haas, Naomi B, Markowski, Mark C, Dhar, Arindam, O'Dwyer, Peter J, Shapiro, Geoffrey I
Published in JNCI cancer spectrum (01.04.2020)
Published in JNCI cancer spectrum (01.04.2020)
Get full text
Journal Article
Phase 1 and preclinical profiling of ESM‐HDAC391, a myeloid‐targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia
Furze, Rebecca C., Molnar, Judit, Parr, Nigel J., Ahmad, Faiz, Henry, Yvette, Howe, David, Singh, Rajendra, Toal, Martin, Bassil, Anna K., Bernard, Sharon G., Davis, Robert P., Gibson, Adele, Maller, N. Claire, Sharp, Catriona, Tough, David F., Prinjha, Rab K., Lewis, Huw D.
Published in British journal of clinical pharmacology (01.12.2022)
Published in British journal of clinical pharmacology (01.12.2022)
Get full text
Journal Article
Extramammary Paget's disease of the penis: a case report and review of the literature
Ekwueme, Kingsley C, Zakhour, Hani D, Parr, Nigel J
Published in Journal of medical case reports (06.01.2009)
Published in Journal of medical case reports (06.01.2009)
Get full text
Journal Article
The treatment of penile carcinoma in situ (CIS) within a UK supra‐regional network
Lucky, Marc, Murthy, Kusuma V.R., Rogers, Beverley, Jones, Stephen, Lau, Maurice W., Sangar, Vijay K., Parr, Nigel J.
Published in BJU international (01.04.2015)
Published in BJU international (01.04.2015)
Get full text
Journal Article
Should centralized histopathological review in penile cancer be the global standard?
Tang, Vincent, Clarke, Laurence, Gall, Zara, Shanks, Jonathan H., Nonaka, Daisuke, Parr, Nigel J., Elliott, P. Anthony, Clarke, Noel W., Ramani, Vijay, Lau, Maurice W., Sangar, Vijay K.
Published in BJU international (01.09.2014)
Published in BJU international (01.09.2014)
Get full text
Journal Article
Chemical Composition of Gases Surgeons Are Exposed to During Endoscopic Urological Resections
Weston, Robin, Stephenson, Richard N, Kutarski, Paul W, Parr, Nigel J
Published in Urology (Ridgewood, N.J.) (01.11.2009)
Published in Urology (Ridgewood, N.J.) (01.11.2009)
Get full text
Journal Article
Severe eosinophilic cystitis in a woman with anorexia nervosa
PHILIP, JOE, ALI, FAISAL SM, ZAKHOUR, HANI D, PARR, NIGEL J
Published in International journal of urology (01.08.2006)
Published in International journal of urology (01.08.2006)
Get full text
Journal Article