A Gut Microbial Metabolite of Linoleic Acid, 10-Hydroxy-cis-12-octadecenoic Acid, Ameliorates Intestinal Epithelial Barrier Impairment Partially via GPR40-MEK-ERK Pathway
Miyamoto, Junki, Mizukure, Taichi, Park, Si-Bum, Kishino, Shigenobu, Kimura, Ikuo, Hirano, Kanako, Bergamo, Paolo, Rossi, Mauro, Suzuki, Takuya, Arita, Makoto, Ogawa, Jun, Tanabe, Soichi
Published in The Journal of biological chemistry (30.01.2015)
Published in The Journal of biological chemistry (30.01.2015)
Get full text
Journal Article
Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition
Kishino, Shigenobu, Takeuchi, Michiki, Park, Si-Bum, Hirata, Akiko, Kitamura, Nahoko, Kunisawa, Jun, Kiyono, Hiroshi, Iwamoto, Ryo, Isobe, Yosuke, Arita, Makoto, Arai, Hiroyuki, Ueda, Kazumitsu, Shima, Jun, Takahashi, Satomi, Yokozeki, Kenzo, Shimizu, Sakayu, Ogawa, Jun
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (29.10.2013)
Get full text
Journal Article
α-Linolenic acid-derived metabolites from gut lactic acid bacteria induce differentiation of anti-inflammatory M2 macrophages through G protein-coupled receptor 40
Ohue-Kitano, Ryuji, Yasuoka, Yumiko, Goto, Tsuyoshi, Kitamura, Nahoko, Park, Si-Bum, Kishino, Shigenobu, Kimura, Ikuo, Kasubuchi, Mayu, Takahashi, Haruya, Li, Yongjia, Yeh, Yu-Sheng, Jheng, Huei-Fen, Iwase, Mari, Tanaka, Masashi, Masuda, Shinya, Inoue, Takayuki, Yamakage, Hajime, Kusakabe, Toru, Tani, Fumito, Shimatsu, Akira, Takahashi, Nobuyuki, Ogawa, Jun, Satoh-Asahara, Noriko, Kawada, Teruo
Published in The FASEB journal (01.01.2018)
Published in The FASEB journal (01.01.2018)
Get more information
Journal Article
Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage‐mediated inflammation in adipocytes
Yang, Ha‐Eun, Li, Yongjia, Nishimura, Akira, Jheng, Huei‐Fen, Yuliana, Ana, Kitano‐Ohue, Ryuji, Nomura, Wataru, Takahashi, Nobuyuki, Kim, Chu‐Sook, Yu, Rina, Kitamura, Nahoko, Park, Si‐Bum, Kishino, Shigenobu, Ogawa, Jun, Kawada, Teruo, Goto, Tsuyoshi
Published in Molecular nutrition & food research (01.10.2017)
Published in Molecular nutrition & food research (01.10.2017)
Get full text
Journal Article
Supplemental feeding of a gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, alleviates spontaneous atopic dermatitis and modulates intestinal microbiota in NC/nga mice
Kaikiri, Hiroko, Miyamoto, Junki, Kawakami, Takahiro, Park, Si-Bum, Kitamura, Nahoko, Kishino, Shigenobu, Yonejima, Yasunori, Hisa, Keiko, Watanabe, Jun, Ogita, Tasuku, Ogawa, Jun, Tanabe, Soichi, Suzuki, Takuya
Published in International journal of food sciences and nutrition (01.12.2017)
Published in International journal of food sciences and nutrition (01.12.2017)
Get full text
Journal Article
10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress
Furumoto, Hidehiro, Nanthirudjanar, Tharnath, Kume, Toshiaki, Izumi, Yasuhiko, Park, Si-Bum, Kitamura, Nahoko, Kishino, Shigenobu, Ogawa, Jun, Hirata, Takashi, Sugawara, Tatsuya
Published in Toxicology and applied pharmacology (01.04.2016)
Published in Toxicology and applied pharmacology (01.04.2016)
Get full text
Journal Article
Gut Microbial Fatty Acid Metabolites Reduce Triacylglycerol Levels in Hepatocytes
Nanthirudjanar, Tharnath, Furumoto, Hidehiro, Zheng, Jiawen, Kim, Young-Il, Goto, Tsuyoshi, Takahashi, Nobuyuki, Kawada, Teruo, Park, Si-Bum, Hirata, Akiko, Kitamura, Nahoko, Kishino, Shigenobu, Ogawa, Jun, Hirata, Takashi, Sugawara, Tatsuya
Published in Lipids (01.11.2015)
Published in Lipids (01.11.2015)
Get full text
Journal Article
Structure and reaction mechanism of a novel enone reductase
Hou, Feng, Miyakawa, Takuya, Kitamura, Nahoko, Takeuchi, Michiki, Park, Si‐Bum, Kishino, Shigenobu, Ogawa, Jun, Tanokura, Masaru
Published in The FEBS journal (01.04.2015)
Published in The FEBS journal (01.04.2015)
Get full text
Journal Article
Production of dicarboxylic acids from novel unsaturated fatty acids by laccase-catalyzed oxidative cleavage
Takeuchi, Michiki, Kishino, Shigenobu, Park, Si-Bum, Kitamura, Nahoko, Watanabe, Hiroko, Saika, Azusa, Hibi, Makoto, Yokozeki, Kenzo, Ogawa, Jun
Published in Bioscience, biotechnology, and biochemistry (01.11.2016)
Published in Bioscience, biotechnology, and biochemistry (01.11.2016)
Get full text
Journal Article
17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression
Saika, Azusa, Nagatake, Takahiro, Kishino, Shigenobu, Park, Si‐Bum, Honda, Tetsuya, Matsumoto, Naomi, Shimojou, Michiko, Morimoto, Sakiko, Tiwari, Prabha, Node, Eri, Hirata, So‐ichiro, Hosomi, Koji, Kabashima, Kenji, Ogawa, Jun, Kunisawa, Jun
Published in FASEB bioAdvances (01.01.2020)
Published in FASEB bioAdvances (01.01.2020)
Get full text
Journal Article
Hydroxy fatty acid production by Pediococcus sp
Takeuchi, Michiki, Kishino, Shigenobu, Tanabe, Kaori, Hirata, Akiko, Park, Si-Bum, Shimizu, Sakayu, Ogawa, Jun
Published in European journal of lipid science and technology (01.04.2013)
Published in European journal of lipid science and technology (01.04.2013)
Get full text
Journal Article
Characterization of hydroxy fatty acid dehydrogenase involved in polyunsaturated fatty acid saturation metabolism in Lactobacillus plantarum AKU 1009a
Takeuchi, Michiki, Kishino, Shigenobu, Park, Si-Bum, Kitamura, Nahoko, Ogawa, Jun
Published in Journal of molecular catalysis. B, Enzymatic (01.07.2015)
Published in Journal of molecular catalysis. B, Enzymatic (01.07.2015)
Get full text
Journal Article
Gut microbial metabolites of linoleic acid are metabolized by accelerated peroxisomal β-oxidation in mammalian cells
Morito, Katsuya, Shimizu, Ryota, Kitamura, Nahoko, Park, Si-Bum, Kishino, Shigenobu, Ogawa, Jun, Fukuta, Tatsuya, Kogure, Kentaro, Tanaka, Tamotsu
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.11.2019)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.11.2019)
Get full text
Journal Article
Characterization of the linoleic acid Δ9 hydratase catalyzing the first step of polyunsaturated fatty acid saturation metabolism in Lactobacillus plantarum AKU 1009a
Takeuchi, Michiki, Kishino, Shigenobu, Hirata, Akiko, Park, Si-Bum, Kitamura, Nahoko, Ogawa, Jun
Published in Journal of bioscience and bioengineering (01.06.2015)
Published in Journal of bioscience and bioengineering (01.06.2015)
Get full text
Journal Article
10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis
Goto, Tsuyoshi, Kim, Young-Il, Furuzono, Tomoya, Takahashi, Nobuyuki, Yamakuni, Kanae, Yang, Ha-Eun, Li, Yongjia, Ohue, Ryuji, Nomura, Wataru, Sugawara, Tatsuya, Yu, Rina, Kitamura, Nahoko, Park, Si-Bum, Kishino, Shigenobu, Ogawa, Jun, Kawada, Teruo
Published in Biochemical and biophysical research communications (17.04.2015)
Published in Biochemical and biophysical research communications (17.04.2015)
Get full text
Journal Article
Novel multi-component enzyme machinery in lactic acid bacteria catalyzing C C double bond migration useful for conjugated fatty acid synthesis
Kishino, Shigenobu, Park, Si-Bum, Takeuchi, Michiki, Yokozeki, Kenzo, Shimizu, Sakayu, Ogawa, Jun
Published in Biochemical and biophysical research communications (09.12.2011)
Published in Biochemical and biophysical research communications (09.12.2011)
Get full text
Journal Article
Characterization of a trifunctional fatty acid desaturase from oleaginous filamentous fungus Mortierella alpina 1S-4 using a yeast expression system
Kikukawa, Hiroshi, Sakuradani, Eiji, Kishino, Shigenobu, Park, Si-Bum, Ando, Akinori, Shima, Jun, Ochiai, Misa, Shimizu, Sakayu, Ogawa, Jun
Published in Journal of bioscience and bioengineering (01.12.2013)
Published in Journal of bioscience and bioengineering (01.12.2013)
Get full text
Journal Article