EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
Karakashev, Sergey, Fukumoto, Takeshi, Zhao, Bo, Lin, Jianhuang, Wu, Shuai, Fatkhutdinov, Nail, Park, Pyoung-Hwa, Semenova, Galina, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Kossenkov, Andrew V., Liu, Qin, Zhang, Rugang
Published in Cancer cell (10.02.2020)
Published in Cancer cell (10.02.2020)
Get full text
Journal Article
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
Karakashev, Sergey, Zhu, Hengrui, Wu, Shuai, Yokoyama, Yuhki, Bitler, Benjamin G., Park, Pyoung-Hwa, Lee, Jeong-Heon, Kossenkov, Andrew V., Gaonkar, Krutika Satish, Yan, Huihuang, Drapkin, Ronny, Conejo-Garcia, Jose R., Speicher, David W., Ordog, Tamas, Zhang, Rugang
Published in Nature communications (12.02.2018)
Published in Nature communications (12.02.2018)
Get full text
Journal Article
ARID1A-mutated ovarian cancers depend on HDAC6 activity
Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher III, Frank J., Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang
Published in Nature cell biology (01.08.2017)
Published in Nature cell biology (01.08.2017)
Get full text
Journal Article
SWI/SNF catalytic subunits’ switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells
Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Tang, Hsin-Yao, Zhang, Lin, Gardini, Alessandro, Speicher, David W., Zhang, Rugang
Published in Nature communications (08.10.2018)
Published in Nature communications (08.10.2018)
Get full text
Journal Article
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer
Park, Pyoung Hwa, Keith, Kelsey, Calendo, Gennaro, Jelinek, Jaroslav, Madzo, Jozef, Gharaibeh, Raad Z, Ghosh, Jayashri, Sapienza, Carmen, Jobin, Christian, Issa, Jean-Pierre J
Published in Gut microbes (01.01.2024)
Published in Gut microbes (01.01.2024)
Get full text
Journal Article
Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer
Fukumoto, Takeshi, Park, Pyoung Hwa, Wu, Shuai, Fatkhutdinov, Nail, Karakashev, Sergey, Nacarelli, Timothy, Kossenkov, Andrew V., Speicher, David W., Jean, Stephanie, Zhang, Lin, Wang, Tian-Li, Shih, Ie-Ming, Conejo-Garcia, Jose R., Bitler, Benjamin G., Zhang, Rugang
Published in Cell reports (Cambridge) (27.03.2018)
Published in Cell reports (Cambridge) (27.03.2018)
Get full text
Journal Article
Abstract NT-114: CATALYTIC SUBUNITS SWITCH DRIVES RESISTANCE TO EZH2 INHIBITORS IN ARID1A-MUTATED CELLS
Wu, Shuai, Fatkhutdinov, Nail, Fukumoto, Takeshi, Bitler, Benjamin G., Park, Pyoung Hwa, Kossenkov, Andrew V., Trizzino, Marco, Gardini, Alessandro, Speicher, David W., Zhang, Rugang
Published in Clinical cancer research (15.11.2019)
Published in Clinical cancer research (15.11.2019)
Get full text
Journal Article
Abstract LB-141: CIMP is associated with altered microbiota composition in colorectal cancer patients
Park, Pyoung Hwa, Gharaibeh, Raad Z., Cole, Lauren, Sun, Ang, Chung, Woonbok, Jelinek, Jaroslav, Pope, Jillian L., Jobin, Christian, Issa, Jean-Pierre J.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa
Sun, Ang, Park, Pyounghwa, Cole, Lauren, Vaidya, Himani, Maegawa, Shinji, Keith, Kelsey, Calendo, Gennaro, Madzo, Jozef, Jelinek, Jaroslav, Jobin, Christian, Issa, Jean-Pierre J.
Published in Epigenetics (01.12.2023)
Published in Epigenetics (01.12.2023)
Get full text
Journal Article
Amplification of the Mutation-Carrying BRCA2 Allele Promotes RAD51 Loading and PARP Inhibitor Resistance in the Absence of Reversion Mutations
Park, Pyoung Hwa, Yamamoto, Tomomi M, Li, Hua, Alcivar, Allen L, Xia, Bing, Wang, Yifan, Bernhardy, Andrea J, Turner, Kristen M, Kossenkov, Andrew V, Watson, Zachary L, Behbakht, Kian, Casadei, Silvia, Swisher, Elizabeth M, Mischel, Paul S, Johnson, Neil, Bitler, Benjamin G
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
Get full text
Journal Article
Abstract AP25: INHIBITION OF HDAC ACTIVITY SELECTIVELY INHIBITS ARID1A–MUTATED OVARIAN CLEAR CELL CARCINOMA THROUGH A NOVEL P53 REGULATORY MECHANISM
Bitler, Benjamin G., Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Huntsman, David G., Cho, Kathleen R., Christianson, David W., Zhang, Rugang
Published in Clinical cancer research (01.06.2017)
Published in Clinical cancer research (01.06.2017)
Get full text
Journal Article