Chemical genomics reveals histone deacetylases are required for core regulatory transcription
Gryder, Berkley E., Wu, Lei, Woldemichael, Girma M., Pomella, Silvia, Quinn, Taylor R., Park, Paul M. C., Cleveland, Abigail, Stanton, Benjamin Z., Song, Young, Rota, Rossella, Wiest, Olaf, Yohe, Marielle E., Shern, Jack F., Qi, Jun, Khan, Javed
Published in Nature communications (08.07.2019)
Published in Nature communications (08.07.2019)
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Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma
Song, Yan, Park, Paul M. C., Wu, Lei, Ray, Arghya, Picaud, Sarah, Li, Deyao, Wimalasena, Virangika K., Du, Ting, Filippakopoulos, Panagis, Anderson, Kenneth C., Qi, Jun, Chauhan, Dharminder
Published in Leukemia (01.11.2019)
Published in Leukemia (01.11.2019)
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Synthetic transcription elongation factors license transcription across repressive chromatin
Erwin, Graham S., Grieshop, Matthew P., Ali, Asfa, Qi, Jun, Lawlor, Matthew, Kumar, Deepak, Ahmad, Istaq, McNally, Anna, Teider, Natalia, Worringer, Katie, Sivasankaran, Rajeev, Syed, Deeba N., Eguchi, Asuka, Ashraf, Md, Jeffery, Justin, Xu, Mousheng, Park, Paul M. C., Mukhtar, Hasan, Srivastava, Achal K., Faruq, Mohammed, Bradner, James E., Ansari, Aseem Z.
Published in Science (American Association for the Advancement of Science) (22.12.2017)
Published in Science (American Association for the Advancement of Science) (22.12.2017)
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YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis
Ye, Shuai, Lawlor, Matthew A, Rivera-Reyes, Adrian, Egolf, Shaun, Chor, Susan, Pak, Koreana, Ciotti, Gabrielle E, Lee, Avery C, Marino, Gloria E, Shah, Jennifer, Niedzwicki, David, Weber, Kristy, Park, Paul M C, Alam, Md Zahidul, Grazioli, Alison, Haldar, Malay, Xu, Mousheng, Perry, Jennifer A, Qi, Jun, Eisinger-Mathason, T S Karin
Published in Cancer research (Chicago, Ill.) (15.05.2018)
Published in Cancer research (Chicago, Ill.) (15.05.2018)
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EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma
Durbin, Adam D, Wang, Tingjian, Wimalasena, Virangika K, Zimmerman, Mark W, Li, Deyao, Dharia, Neekesh V, Mariani, Luca, Shendy, Noha A M, Nance, Stephanie, Patel, Anand G, Shao, Ying, Mundada, Maya, Maxham, Lily, Park, Paul M C, Sigua, Logan H, Morita, Ken, Conway, Amy Saur, Robichaud, Amanda L, Perez-Atayde, Antonio R, Bikowitz, Melissa J, Quinn, Taylor R, Wiest, Olaf, Easton, John, Schönbrunn, Ernst, Bulyk, Martha L, Abraham, Brian J, Stegmaier, Kimberly, Look, A Thomas, Qi, Jun
Published in Cancer discovery (01.03.2022)
Published in Cancer discovery (01.03.2022)
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Polymerization of ZBTB transcription factors regulates chromatin occupancy
Park, Paul M.C., Park, Jiho, Brown, Jared, Hunkeler, Moritz, Roy Burman, Shourya S., Donovan, Katherine A., Yoon, Hojong, Nowak, Radosław P., Słabicki, Mikołaj, Ebert, Benjamin L., Fischer, Eric S.
Published in Molecular cell (11.07.2024)
Published in Molecular cell (11.07.2024)
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UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability
Tsai, Jonathan M, Aguirre, Jacob D, Li, Yen-Der, Brown, Jared, Focht, Vivian, Kater, Lukas, Kempf, Georg, Sandoval, Brittany, Schmitt, Stefan, Rutter, Justine C, Galli, Pius, Sandate, Colby R, Cutler, Jevon A, Zou, Charles, Donovan, Katherine A, Lumpkin, Ryan J, Cavadini, Simone, Park, Paul M C, Sievers, Quinlan, Hatton, Charlie, Ener, Elizabeth, Regalado, Brandon D, Sperling, Micah T, Słabicki, Mikołaj, Kim, Jeonghyeon, Zon, Rebecca, Zhang, Zinan, Miller, Peter G, Belizaire, Roger, Sperling, Adam S, Fischer, Eric S, Irizarry, Rafael, Armstrong, Scott A, Thomä, Nicolas H, Ebert, Benjamin L
Published in Molecular cell (03.08.2023)
Published in Molecular cell (03.08.2023)
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BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models
Zhao, Xiaohong, Ren, Yuan, Lawlor, Matthew, Shah, Bijal D., Park, Paul M.C., Lwin, Tint, Wang, Xuefeng, Liu, Kenian, Wang, Michelle, Gao, Jing, Li, Tao, Xu, Mousheng, Silva, Ariosto S., Lee, Kaplan, Zhang, Tinghu, Koomen, John M., Jiang, Huijuan, Sudalagunta, Praneeth R., Meads, Mark B., Cheng, Fengdong, Bi, Chengfeng, Fu, Kai, Fan, Huitao, Dalton, William S., Moscinski, Lynn C., Shain, Kenneth H., Sotomayor, Eduardo M., Wang, Gang Greg, Gray, Nathanael S., Cleveland, John L., Qi, Jun, Tao, Jianguo
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Template-assisted covalent modification underlies activity of covalent molecular glues
Li, Yen-Der, Ma, Michelle W, Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Rutter, Justine C, Lumpkin, Ryan J, Sandoval, Brittany, Jin, Cyrus Y, Schmoker, Anna M, Ficarro, Scott B, Cheong, Hakyung, Metivier, Rebecca J, Wang, Michelle Y, Xu, Shawn, Byun, Woong Sub, Groendyke, Brian J, You, Inchul, Sigua, Logan H, Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M, Park, Paul M C, Yoon, Hojong, Majewski, Felix C, Sperling, Haniya T, Marto, Jarrod A, Qi, Jun, Nowak, Radosław P, Donovan, Katherine A, Słabicki, Mikołaj, Gray, Nathanael S, Fischer, Eric S, Ebert, Benjamin L
Published in Nature chemical biology (29.07.2024)
Published in Nature chemical biology (29.07.2024)
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BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes
Zaiken, Michael C., Flynn, Ryan, Paz, Katelyn G., Rhee, Stephanie Y., Jin, Sujeong, Mohamed, Fathima A., Saha, Asim, Thangavelu, Govindarajan, Park, Paul M.C., Hemming, Matthew L., Sage, Peter T., Sharpe, Arlene H., DuPage, Michel, Bluestone, Jeffrey A., Panoskaltsis-Mortari, Angela, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Luznik, Leo, Maillard, Ivan, Hill, Geoffrey R., MacDonald, Kelli P.A., Munn, David H., Serody, Jonathan S., Murphy, William J., Kean, Leslie S., Zhang, Yi, Bradner, James E., Qi, Jun, Blazar, Bruce R.
Published in Blood (12.05.2022)
Published in Blood (12.05.2022)
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A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma
Pak, Ekaterina, MacKenzie, Ethan L, Zhao, Xuesong, Pazyra-Murphy, Maria F, Park, Paul M C, Wu, Lei, Shaw, Daniel L, Addleson, Emily C, Cayer, Suzanne S, Lopez, Begoña G-C, Agar, Nathalie Y R, Rubin, Lee L, Qi, Jun, Merk, Daniel J, Segal, Rosalind A
Published in Neuro-oncology (Charlottesville, Va.) (06.09.2019)
Published in Neuro-oncology (Charlottesville, Va.) (06.09.2019)
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YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma
Rivera-Reyes, Adrian, Ye, Shuai, E. Marino, Gloria, Egolf, Shaun, E. Ciotti, Gabrielle, Chor, Susan, Liu, Ying, Posimo, Jessica M., Park, Paul M. C., Pak, Koreana, Babichev, Yael, Sostre-Colón, Jaimarie, Tameire, Feven, Leli, Nektaria Maria, Koumenis, Constantinos, C. Brady, Donita, Mancuso, Anthony, Weber, Kristy, Gladdy, Rebecca, Qi, Jun, Eisinger-Mathason, T. S. Karin
Published in Cell death & disease (31.10.2018)
Published in Cell death & disease (31.10.2018)
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Journal Article
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma
Ohguchi, Hiroto, Park, Paul M C, Wang, Tingjian, Gryder, Berkley E, Ogiya, Daisuke, Kurata, Keiji, Zhang, Xiaofeng, Li, Deyao, Pei, Chengkui, Masuda, Takeshi, Johansson, Catrine, Wimalasena, Virangika K, Kim, Yong, Hino, Shinjiro, Usuki, Shingo, Kawano, Yawara, Samur, Mehmet K, Tai, Yu-Tzu, Munshi, Nikhil C, Matsuoka, Masao, Ohtsuki, Sumio, Nakao, Mitsuyoshi, Minami, Takashi, Lauberth, Shannon, Khan, Javed, Oppermann, Udo, Durbin, Adam D, Anderson, Kenneth C, Hideshima, Teru, Qi, Jun
Published in Blood cancer discovery (01.07.2021)
Published in Blood cancer discovery (01.07.2021)
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The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein
Zou, Charles, Yoon, Hojong, Park, Paul M.C., Patten, J.J., Pellman, Jesse, Carreiro, Jeannie, Tsai, Jonathan M., Li, Yen-Der, Roy Burman, Shourya S., Donovan, Katherine A., Gasser, Jessica, Sperling, Adam S., Nowak, Radosław P., Fischer, Eric S., Davey, Robert A., Ebert, Benjamin L., Słabicki, Mikołaj
Published in iScience (19.05.2023)
Published in iScience (19.05.2023)
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Journal Article
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Li, Yen-Der, Ma, Michelle W, Hassan, Muhammad Murtaza, Hunkeler, Moritz, Teng, Mingxing, Puvar, Kedar, Lumpkin, Ryan, Sandoval, Brittany, Jin, Cyrus Y, Ficarro, Scott B, Wang, Michelle Y, Xu, Shawn, Groendyke, Brian J, Sigua, Logan H, Tavares, Isidoro, Zou, Charles, Tsai, Jonathan M, Park, Paul M C, Yoon, Hojong, Majewski, Felix C, Marto, Jarrod A, Qi, Jun, Nowak, Radosław P, Donovan, Katherine A, Słabicki, Mikołaj, Gray, Nathanael S, Fischer, Eric S, Ebert, Benjamin L
Published in bioRxiv (15.02.2023)
Published in bioRxiv (15.02.2023)
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Paper
Abstract LB193: Lysine demethylase 5A is required for MYC driven transcription in multiple myeloma
Qi, Jun, Ohguchi, hiroto, Park, Paul MC, wang, tingjian, Anderson, Kenneth C., Hideshima, Teru, Johansson, Catrine, Oppermann, Udo, Durbin, Adam D., Gryder, Berkley, Khan, Javed, zhang, xiaofeng
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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