A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC
Mohammad, Helai P., Smitheman, Kimberly N., Kamat, Chandrashekhar D., Soong, David, Federowicz, Kelly E., Van Aller, Glenn S., Schneck, Jess L., Carson, Jeffrey D., Liu, Yan, Butticello, Michael, Bonnette, William G., Gorman, Shelby A., Degenhardt, Yan, Bai, Yuchen, McCabe, Michael T., Pappalardi, Melissa B., Kasparec, Jiri, Tian, Xinrong, McNulty, Kenneth C., Rouse, Meagan, McDevitt, Patrick, Ho, Thau, Crouthamel, Michelle, Hart, Timothy K., Concha, Nestor O., McHugh, Charles F., Miller, William H., Dhanak, Dashyant, Tummino, Peter J., Carpenter, Christopher L., Johnson, Neil W., Hann, Christine L., Kruger, Ryan G.
Published in Cancer cell (13.07.2015)
Published in Cancer cell (13.07.2015)
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Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
McCabe, Michael T, Graves, Alan P, Ganji, Gopinath, Diaz, Elsie, Halsey, Wendy S, Jiang, Yong, Smitheman, Kimberly N, Ott, Heidi M, Pappalardi, Melissa B, Allen, Kimberly E, Chen, Stephanie B, Della Pietra, Anthony III, Dul, Edward, Hughes, Ashley M, Gilbert, Seth A, Thrall, Sara H, Tummino, Peter J, Kruger, Ryan G, Brandt, Martin, Schwartz, Benjamin, Creasy, Caretha L
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (21.02.2012)
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A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation
Ge, Alex Y., Arab, Abolfazl, Dai, Raymond, Navickas, Albertas, Fish, Lisa, Garcia, Kristle, Asgharian, Hosseinali, Goudreau, Jackson, Lee, Sean, Keenan, Kathryn, Pappalardi, Melissa B., McCabe, Michael T., Przybyla, Laralynne, Goodarzi, Hani, Gilbert, Luke A.
Published in Scientific reports (29.10.2024)
Published in Scientific reports (29.10.2024)
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Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all- trans retinoic acid in acute myeloid leukemia across subtypes
Smitheman, Kimberly N, Severson, Tesa M, Rajapurkar, Satyajit R, McCabe, Michael T, Karpinich, Natalie, Foley, James, Pappalardi, Melissa B, Hughes, Ashley, Halsey, Wendy, Thomas, Elizabeth, Traini, Christopher, Federowicz, Kelly E, Laraio, Jenny, Mobegi, Fredrick, Ferron-Brady, Geraldine, Prinjha, Rabinder K, Carpenter, Christopher L, Kruger, Ryan G, Wessels, Lodewyk, Mohammad, Helai P
Published in Haematologica (Roma) (01.06.2019)
Published in Haematologica (Roma) (01.06.2019)
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A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation
Ott, Heidi M, Graves, Alan P, Pappalardi, Melissa B, Huddleston, Michael, Halsey, Wendy S, Hughes, Ashley M, Groy, Arthur, Dul, Edward, Jiang, Yong, Bai, Yuchen, Annan, Roland, Verma, Sharad K, Knight, Steven D, Kruger, Ryan G, Dhanak, Dashyant, Schwartz, Benjamin, Tummino, Peter J, Creasy, Caretha L, McCabe, Michael T
Published in Molecular cancer therapeutics (01.12.2014)
Published in Molecular cancer therapeutics (01.12.2014)
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Dnmt1 has de novo activity targeted to transposable elements
Haggerty, Chuck, Kretzmer, Helene, Riemenschneider, Christina, Kumar, Abhishek Sampath, Mattei, Alexandra L., Bailly, Nina, Gottfreund, Judith, Giesselmann, Pay, Weigert, Raha, Brändl, Björn, Giehr, Pascal, Buschow, René, Galonska, Christina, von Meyenn, Ferdinand, Pappalardi, Melissa B., McCabe, Michael T., Wittler, Lars, Giesecke-Thiel, Claudia, Mielke, Thorsten, Meierhofer, David, Timmermann, Bernd, Müller, Franz-Josef, Walter, Jörn, Meissner, Alexander
Published in Nature structural & molecular biology (01.07.2021)
Published in Nature structural & molecular biology (01.07.2021)
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Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
Wiseman, Ashley K., Tiedemann, Rochelle L., Fan, Huihui, Shen, Hui, Madaj, Zachary, McCabe, Michael T., Pappalardi, Melissa B., Jones, Peter A.
Published in Communications biology (02.06.2022)
Published in Communications biology (02.06.2022)
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EP-1990: Comparison of dose optimisation methods for vaginal HDR brachytherapy with multichannel applicators
Cusumano, D, Carrara, M, Borroni, M, Tenconi, C, Grisotto, S, Mazzarella, E, Cerrotta, A, Pappalardi, B, Fallai, C, Pignoli, E
Published in Radiotherapy and oncology (01.04.2016)
Published in Radiotherapy and oncology (01.04.2016)
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Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites
Pappalardi, Melissa B, McNulty, Dean E, Martin, John D, Fisher, Kelly E, Jiang, Yong, Burns, Matthew C, Zhao, Huizhen, Ho, Thau, Sweitzer, Sharon, Schwartz, Benjamin, Annan, Roland S, Copeland, Robert A, Tummino, Peter J, Luo, Lusong
Published in Biochemical journal (01.06.2011)
Published in Biochemical journal (01.06.2011)
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PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Patel, Amish J, Warda, Sarah, Maag, Jesper L V, Misra, Rohan, Miranda-Román, Miguel A, Pachai, Mohini R, Lee, Cindy J, Li, Dan, Wang, Naitao, Bayshtok, Gabriella, Fishinevich, Eve, Meng, Yinuo, Wong, Elissa W P, Yan, Juan, Giff, Emily, Pappalardi, Melissa B, McCabe, Michael T, Fletcher, Jonathan A, Rudin, Charles M, Chandarlapaty, Sarat, Scandura, Joseph M, Koche, Richard P, Glass, Jacob L, Antonescu, Cristina R, Zheng, Deyou, Chen, Yu, Chi, Ping
Published in Cancer discovery (02.09.2022)
Published in Cancer discovery (02.09.2022)
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OC-0175: In vivo rectal dose measures compared to planned and reconstructed doses in US-based HDR prostate brachytherapy
Carrara, M, Tenconi, C, Cutajar, D, Borroni, M, Grisotto, S, Cerrotta, A, Pappalardi, B, Fallai, C, Petasecca, M, Bucci, J, Lerch, M, Gambarini, G, Rosenfeld, A, Pignoli, E
Published in Radiotherapy and oncology (01.04.2015)
Published in Radiotherapy and oncology (01.04.2015)
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PO-0701: Toxicity and outcome of recurrent prostate cancer patients treated with 11-C Choline PET/CT-guided tomotherapy
Berardi, G, Fodor, A, Pappalardi, B, Fiorino, C, Cozzarini, C, Guazzoni, G, Calandrino, R, Di Muzio, N.G
Published in Radiotherapy and oncology (01.03.2013)
Published in Radiotherapy and oncology (01.03.2013)
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Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing
Gerhart, Sarah V., Kellner, Wendy A., Thompson, Christine, Pappalardi, Melissa B., Zhang, Xi-Ping, Montes de Oca, Rocio, Penebre, Elayne, Duncan, Kenneth, Boriack-Sjodin, Ann, Le, BaoChau, Majer, Christina, McCabe, Michael T., Carpenter, Chris, Johnson, Neil, Kruger, Ryan G., Barbash, Olena
Published in Scientific reports (26.06.2018)
Published in Scientific reports (26.06.2018)
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Development and application of a trans-rectal US probe integrated with MOSkin dosimeters: In vivo rectal wall measurements during HDR prostate brachytherapy
Carrara, M, Tenconi, C, Rossi, G, Borroni, M, Cerrotta, A, Grisotto, S, Pappalardi, B, Cutajar, D, Petasecca, M, Lerch, M, Bucci, J, Fallai, C, Gambarini, G, Rosenfeld, A, Pignoli, E
Published in Physica medica (01.02.2016)
Published in Physica medica (01.02.2016)
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Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors
Horton, John R., Pathuri, Sarath, Wong, Kristen, Ren, Ren, Rueda, Lourdes, Fosbenner, David T., Heerding, Dirk A., McCabe, Michael T., Pappalardi, Melissa B., Zhang, Xing, King, Bryan W., Cheng, Xiaodong
Published in Structure (London) (02.06.2022)
Published in Structure (London) (02.06.2022)
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Hypofractionated Tomotherapy Treatment (HTT) in Prostate Cancer Lymph Nodal Relapse Detected by 11C-Choline PET/CT
Berardi, G, Alongi, F, Fiorino, C, Pappalardi, B, Pasetti, M, Mangili, P, Guazzoni, G, Calandrino, R, Di Muzio, N.G
Published in International journal of radiation oncology, biology, physics (2010)
Published in International journal of radiation oncology, biology, physics (2010)
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High-dose Moderately Hypofractionated Tomotherapy for Localized Prostate Cancer: Promising 3-year Results
Di Muzio, N, Fiorino, C, Cozzarini, C, Alongi, F, Pappalardi, B, Mangili, P, Valdagni, R, Berardi, G, Calandrino, R, Guazzoni, G
Published in International journal of radiation oncology, biology, physics (2010)
Published in International journal of radiation oncology, biology, physics (2010)
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An assay for Fe(II)/2-oxoglutarate-dependent dioxygenases by enzyme-coupled detection of succinate formation
Luo, Lusong, Pappalardi, Melissa B., Tummino, Peter J., Copeland, Robert A., Fraser, Marie E., Grzyska, Piotr K., Hausinger, Robert P.
Published in Analytical biochemistry (01.06.2006)
Published in Analytical biochemistry (01.06.2006)
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Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens
Diaz, Elsie, Machutta, Carl A, Chen, Stephanie, Jiang, Yong, Nixon, Christopher, Hofmann, Glenn, Key, Danielle, Sweitzer, Sharon, Patel, Mehul, Wu, Zining, Creasy, Caretha L, Kruger, Ryan G, LaFrance, Louis, Verma, Sharad K, Pappalardi, Melissa B, Le, Baochau, Van Aller, Glenn S, McCabe, Michael T, Tummino, Peter J, Pope, Andrew J, Thrall, Sara H, Schwartz, Benjamin, Brandt, Martin
Published in Journal of biomolecular screening (01.12.2012)
Published in Journal of biomolecular screening (01.12.2012)
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