Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1
Tardif, Keith D, Rogers, Aaron, Cassiano, Jared, Roth, Bruce L, Cimbora, Daniel M, McKinnon, Rena, Peterson, Ashley, Douce, Thomas B, Robinson, Rosann, Dorweiler, Irene, Davis, Thaylon, Hess, Mark A, Ostanin, Kirill, Papac, Damon I, Baichwal, Vijay, McAlexander, Ian, Willardsen, J Adam, Saunders, Michael, Christophe, Hoarau, Kumar, D Vijay, Wettstein, Daniel A, Carlson, Robert O, Williams, Brandi L
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys
Jones, Andrew J.S, Papac, Damon I, Chin, Edward H, Keck, Rodney, Baughman, Sharon A, Lin, Yvonne S, Kneer, Johannes, Battersby, John E
Published in Glycobiology (Oxford) (01.05.2007)
Published in Glycobiology (Oxford) (01.05.2007)
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Discovery of (2S)‑1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]‑9H‑purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor
Kim, Se-Ho, Bajji, Ashok, Tangallapally, Rajendra, Markovitz, Benjamin, Trovato, Richard, Shenderovich, Mark, Baichwal, Vijay, Bartel, Paul, Cimbora, Daniel, McKinnon, Rena, Robinson, Rosann, Papac, Damon, Wettstein, Daniel, Carlson, Robert, Yager, Kraig M
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors
Vijay Kumar, D., Hoarau, Christophe, Bursavich, Matthew, Slattum, Paul, Gerrish, David, Yager, Kraig, Saunders, Michael, Shenderovich, Mark, Roth, Bruce L., McKinnon, Rena, Chan, Ashley, Cimbora, Daniel M., Bradford, Chad, Reeves, Leslie, Patton, Scott, Papac, Damon I., Williams, Brandi L., Carlson, Robert O.
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
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Quantification of recombinant human parathyroid hormone (rhPTH(1-84)) in human plasma by immunoassay: Commercial kit evaluation and validation to support pharmacokinetic studies
Sukovaty, Richard L., Lee, Jean W., Fox, John, Toney, Karen, Papac, Damon I., Grover, Thomas A., Wells, David S.
Published in Journal of pharmaceutical and biomedical analysis (18.09.2006)
Published in Journal of pharmaceutical and biomedical analysis (18.09.2006)
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Direct Analysis of Affinity-Bound Analytes by MALDI/TOF MS
Papac, Damon I, Hoyes, John, Tomer, Kenneth B
Published in Analytical chemistry (Washington) (01.09.1994)
Published in Analytical chemistry (Washington) (01.09.1994)
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Mass spectrometric identification of phosphorylation sites in bleached bovine rhodopsin
Papac, Damon I, Oatis, John E, Crouch, Rosalie K, Knapp, Daniel R
Published in Biochemistry (Easton) (15.06.1993)
Published in Biochemistry (Easton) (15.06.1993)
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Pharmacokinetic and Chemical Synthesis Optimization of a Potent d‑Peptide HIV Entry Inhibitor Suitable for Extended-Release Delivery
Redman, Joseph S, Francis, J. Nicholas, Marquardt, Robert, Papac, Damon, Mueller, Alan L, Eckert, Debra M, Welch, Brett D, Kay, Michael S
Published in Molecular pharmaceutics (05.03.2018)
Published in Molecular pharmaceutics (05.03.2018)
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Journal Article
Discovery of (2 S )-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9 H -purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor
Kim, Se-Ho, Bajji, Ashok, Tangallapally, Rajendra, Markovitz, Benjamin, Trovato, Richard, Shenderovich, Mark, Baichwal, Vijay, Bartel, Paul, Cimbora, Daniel, McKinnon, Rena, Robinson, Rosann, Papac, Damon, Wettstein, Daniel, Carlson, Robert, Yager, Kraig M.
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
Discovery of an l-alanine ester prodrug of the Hsp90 inhibitor, MPC-3100
Kim, Se-Ho, Tangallapally, Rajendra, Kim, In Chul, Trovato, Richard, Parker, Daniel, Patton, J. Scott, Reeves, Leslie, Bradford, Chad, Wettstein, Daniel, Baichwal, Vijay, Papac, Damon, Bajji, Ashok, Carlson, Robert, Yager, Kraig M.
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Abstract 2628: Antitumor activity of MPC-3100, a synthetic Hsp90 inhibitor, in combination with erlotinib and sorafenib
Baichwal, Vijay R., Brown, Brita, Wettstein, Daniel, Papac, Damon I., Mather, Gary G., Carlson, Robert O.
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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11th GCC Closed Forum: cumulative stability; matrix stability; immunogenicity assays; laboratory manuals; biosimilars; chiral methods; hybrid LBA/LCMS assays; fit-for-purpose validation; China Food and Drug Administration bioanalytical method validation
Islam, Rafiq, Briscoe, Chad, Bower, Joseph, Cape, Stephanie, Arnold, Mark, Hayes, Roger, Warren, Mark, Karnik, Shane, Stouffer, Bruce, Xiao, Yi Qun, van der Strate, Barry, Sikkema, Daniel, Fang, Xinping, Tudoroniu, Ariana, Tayyem, Rabab, Brant, Ashley, Spriggs, Franklin, Barry, Colin, Khan, Masood, Keyhani, Anahita, Zimmer, Jennifer, Caturla, Maria Cruz, Couerbe, Philippe, Khadang, Ardeshir, Bourdage, James, Datin, Jim, Zemo, Jennifer, Hughes, Nicola, Fatmi, Saadya, Sheldon, Curtis, Fountain, Scott, Satterwhite, Christina, Colletti, Kelly, Vija, Jenifer, Yu, Mathilde, Stamatopoulos, John, Lin, Jenny, Wilfahrt, Jim, Dinan, Andrew, Ohorodnik, Susan, Hulse, James, Patel, Vimal, Garofolo, Wei, Savoie, Natasha, Brown, Michael, Papac, Damon, Buonarati, Mike, Hristopoulos, George, Beaver, Chris, Boudreau, Nadine, Williard, Clark, Liu, Yansheng, Ray, Gene, Warrino, Dominic, Xu, Allan, Green, Rachel, Hayward-Sewell, Joanne, Marcelletti, John, Sanchez, Christina, Kennedy, Michael, Charles, Jessica St, Bouhajib, Mohammed, Nehls, Corey, Tabler, Edward, Tu, Jing, Joyce, Philip, Iordachescu, Adriana, DuBey, Ira, Lindsay, John, Yamashita, Jim, Wells, Edward
Published in Bioanalysis (01.04.2018)
Published in Bioanalysis (01.04.2018)
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Abstract B137: Pharmacokinetics, antitumor activity, and therapeutic index of Nampt inhibitor MPC-8640 in mice
Carlson, Robert, Willardsen, Adam, Lockman, Jeffrey, Bradford, Chad, Patton, Scott, Papac, Damon, Boniface, Jay, Yager, Kraig, Baichwal, Vijay
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Journal Article
Combination electrospray-liquid secondary ion mass spectrometry ion source
Papac, Damon I, Schey, Kevin L, Knapp, Daniel R
Published in Analytical chemistry (Washington) (01.08.1991)
Published in Analytical chemistry (Washington) (01.08.1991)
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Journal Article
Parathyroid hormone is a heparin/polyanion binding protein: Binding energetics and structure modification
Kamerzell, Tim J., Joshi, Sangeeta B., McClean, Donald, Peplinskie, Lori, Toney, Karen, Papac, Damon, Li, Meili, Middaugh, C. Russell
Published in Protein science (01.06.2007)
Published in Protein science (01.06.2007)
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