Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists
Staas, Donnette D., Bell, Ian M., Burgey, Christopher S., Deng, James Z., Gallicchio, Steven N., Lim, John J., Paone, Daniel V., Potteiger, Craig M., Shaw, Anthony W., Stevenson, Heather, Stump, Craig A., Blair Zartman, C., Moore, Eric L., Bruno, Joseph G., Mosser, Scott D., White, Rebecca B., Kane, Stefanie A., Salvatore, Christopher A., Graham, Samuel L., Williams, Theresa M., Selnick, Harold G., Fraley, Mark E.
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
Published in Bioorganic & medicinal chemistry letters (01.11.2024)
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Comparison of a novel potentiator of CFTR channel activity to ivacaftor in ameliorating mucostasis caused by cigarette smoke in primary human bronchial airway epithelial cells
Tanjala, Adrian Constantin, Jiang, Jia Xin, Eckford, Paul D W, Ramjeesingh, Mohabir, Li, Canhui, Huan, Ling Jun, Langeveld, Gabrielle, Townsend, Claire, Paone, Daniel V, Busch-Petersen, Jakob, Pekhletski, Roman, Tang, LiPing, Raju, Vamsee, Rowe, Steven M, Bear, Christine E
Published in Respiratory research (10.07.2024)
Published in Respiratory research (10.07.2024)
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Pharmacological Characterization of MK-0974 [N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a Potent and Orally Active Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine
Salvatore, Christopher A, Hershey, James C, Corcoran, Halea A, Fay, John F, Johnston, Victor K, Moore, Eric L, Mosser, Scott D, Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M, Koblan, Kenneth S, Kane, Stefanie A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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Potent, Orally Bioavailable Calcitonin Gene-Related Peptide Receptor Antagonists for the Treatment of Migraine: Discovery of N-[(3R,6S)-6-(2,3-Difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974)
Paone, Daniel V, Shaw, Anthony W, Nguyen, Diem N, Burgey, Christopher S, Deng, James Z, Kane, Stefanie A, Koblan, Kenneth S, Salvatore, Christopher A, Mosser, Scott D, Johnston, Victor K, Wong, Bradley K, Miller-Stein, Cynthia M, Hershey, James C, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Journal of medicinal chemistry (15.11.2007)
Published in Journal of medicinal chemistry (15.11.2007)
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Expanding the scope of the Cu assisted Suzuki–Miyaura reaction
Crowley, Brendan M., Potteiger, Craig M., Deng, James Z., Prier, Christopher K., Paone, Daniel V., Burgey, Christopher S.
Published in Tetrahedron letters (28.09.2011)
Published in Tetrahedron letters (28.09.2011)
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Direct Stereo- and Enantiocontrolled Synthesis of Vicinal Stereogenic Quaternary Carbon Centers. Total Syntheses of meso- and (−)-Chimonanthine and (+)-Calycanthine
Overman, Larry E, Paone, Daniel V, Stearns, Brian A
Published in Journal of the American Chemical Society (25.08.1999)
Published in Journal of the American Chemical Society (25.08.1999)
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Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis
Ginnetti, Anthony T., Paone, Daniel V., Nanda, Kausik K., Li, Jing, Busuek, Marina, Johnson, Scott A., Lu, Jun, Soisson, Stephen M., Robinson, Ronald, Fisher, John, Webber, Andrea, Wesolowski, Gregg, Ma, Bennett, Duong, Le, Carroll, Steven, Burgey, Christopher S., Stachel, Shawn J.
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
Published in Bioorganic & medicinal chemistry letters (15.10.2022)
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Discovery of novel N-1 substituted pyrazolopyrimidinones as potent, selective PDE2 inhibitors
Morriello, Gregori J., Dwyer, Michael P., Chen, Yili, Ginetti, Anthony T., Xu, Shimin, Lu, Jun, Abeywickrema, Pravien, Wang, Deping, Crespo, Alejandro, Cabalu, Tamara D., Wilson, Jonathan E., Stachel, Shawn J., Paone, Daniel V., Sinz, Christopher
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
Published in Bioorganic & medicinal chemistry letters (15.07.2021)
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Identification of second-generation P2X3 antagonists for treatment of pain
Ginnetti, Anthony T., Paone, Daniel V., Stauffer, Shaun R., Potteiger, Craig M., Shaw, Anthony W., Deng, James, Mulhearn, James J., Nguyen, Diem N., Segerdell, Carolyn, Anquandah, Juliana, Calamari, Amy, Cheng, Gong, Leitl, Michael D., Liang, Annie, Moore, Eric, Panigel, Jacqueline, Urban, Mark, Wang, Jixin, Fillgrove, Kerry, Tang, Cuyue, Cook, Sean, Kane, Stefanie, Salvatore, Christopher A., Graham, Samuel L., Burgey, Christopher S.
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
Published in Bioorganic & medicinal chemistry letters (01.05.2018)
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Structure-Guided Design and Procognitive Assessment of a Potent and Selective Phosphodiesterase 2A Inhibitor
Stachel, Shawn J, Berger, Richard, Nomland, Ashley B, Ginnetti, Anthony T, Paone, Daniel V, Wang, Deping, Puri, Vanita, Lange, Henry, Drott, Jason, Lu, Jun, Marcus, Jacob, Dwyer, Michael P, Suon, Sokreine, Uslaner, Jason M, Smith, Sean M
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Novel oxazolidinone calcitonin gene-related peptide (CGRP) receptor antagonists for the acute treatment of migraine
Crowley, Brendan M., Stump, Craig A., Nguyen, Diem N., Potteiger, Craig M., McWherter, Melody A., Paone, Daniel V., Quigley, Amy G., Bruno, Joseph G., Cui, Dan, Culberson, J. Christopher, Danziger, Andrew, Fandozzi, Christine, Gauvreau, Danny, Kemmerer, Amanda L., Menzel, Karsten, Moore, Eric L., Mosser, Scott D., Reddy, Vijay, White, Rebecca B., Salvatore, Christopher A., Kane, Stefanie A., Bell, Ian M., Selnick, Harold G., Fraley, Mark E., Burgey, Christopher S.
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
Published in Bioorganic & medicinal chemistry letters (01.11.2015)
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Synthesis of the (3R,6S)-3-Amino-6-(2,3-difluorophenyl)azepan-2-one of Telcagepant (MK-0974), a Calcitonin Gene-Related Peptide Receptor Antagonist for the Treatment of Migraine Headache
Burgey, Christopher S, Paone, Daniel V, Shaw, Anthony W, Deng, James Z, Nguyen, Diem N, Potteiger, Craig M, Graham, Samuel L, Vacca, Joseph P, Williams, Theresa M
Published in Organic letters (07.08.2008)
Published in Organic letters (07.08.2008)
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Journal Article
Enantioselective Total Syntheses of Ditryptophenaline and ent-WIN 64821
OVERMAN, Larry E., PAONE, Daniel V.
Published in Journal of the American Chemical Society (26.09.2001)
Published in Journal of the American Chemical Society (26.09.2001)
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Journal Article
Examining the binding properties of MK-0974: A CGRP receptor antagonist for the acute treatment of migraine
Moore, Eric L., Burgey, Christopher S., Paone, Daniel V., Shaw, Anthony W., Tang, Yui S., Kane, Stefanie A., Salvatore, Christopher A.
Published in European journal of pharmacology (14.01.2009)
Published in European journal of pharmacology (14.01.2009)
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Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
Manley, Peter J., Zartman, Amy, Paone, Daniel V., Burgey, Christopher S., Henze, Darrell A., Penna, Kimberly Della, Desai, Reshma, Leitl, Michael D., Lemaire, Wei, White, Rebecca B., Yeh, Suzie, Urban, Mark O., Kane, Stefanie A., Hartman, George D., Bilodeau, Mark T., Trotter, B. Wesley
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918
Paone, Daniel V., Nguyen, Diem N., Shaw, Anthony W., Burgey, Christopher S., Potteiger, Craig M., Deng, James Z., Mosser, Scott D., Salvatore, Christopher A., Yu, Sean, Roller, Shane, Kane, Stefanie A., Selnick, Harold G., Vacca, Joseph P., Williams, Theresa M.
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
Published in Bioorganic & medicinal chemistry letters (01.05.2011)
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