Therapeutic strategies for Alzheimer's disease in clinical trials
Godyń, Justyna, Jończyk, Jakub, Panek, Dawid, Malawska, Barbara
Published in Pharmacological reports (01.02.2016)
Published in Pharmacological reports (01.02.2016)
Get full text
Journal Article
Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease-Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors
Góral, Izabella, Wichur, Tomasz, Sługocka, Emilia, Godyń, Justyna, Szałaj, Natalia, Zaręba, Paula, Głuch-Lutwin, Monika, Mordyl, Barbara, Panek, Dawid, Więckowska, Anna
Published in Molecules (Basel, Switzerland) (01.06.2024)
Published in Molecules (Basel, Switzerland) (01.06.2024)
Get full text
Journal Article
Structure-Guided Design of N -Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease
Svobodova, Barbora, Pulkrabkova, Lenka, Panek, Dawid, Misiachna, Anna, Kolcheva, Marharyta, Andrys, Rudolf, Handl, Jiri, Capek, Jan, Nyvltova, Pavlina, Rousar, Tomas, Prchal, Lukas, Hepnarova, Vendula, Hrabinova, Martina, Muckova, Lubica, Tosnerova, Daniela, Karabanovich, Galina, Finger, Vladimir, Soukup, Ondrej, Horak, Martin, Korabecny, Jan
Published in International journal of molecular sciences (23.05.2023)
Published in International journal of molecular sciences (23.05.2023)
Get full text
Journal Article
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents
Panek, Dawid, Więckowska, Anna, Pasieka, Anna, Godyń, Justyna, Jończyk, Jakub, Bajda, Marek, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara
Published in Molecules (Basel, Switzerland) (07.02.2018)
Published in Molecules (Basel, Switzerland) (07.02.2018)
Get full text
Journal Article
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
Hebda, Michalina, Bajda, Marek, Więckowska, Anna, Szałaj, Natalia, Pasieka, Anna, Panek, Dawid, Godyń, Justyna, Wichur, Tomasz, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara
Published in Molecules (Basel, Switzerland) (26.03.2016)
Published in Molecules (Basel, Switzerland) (26.03.2016)
Get full text
Journal Article
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease
Szałaj, Natalia, Godyń, Justyna, Jończyk, Jakub, Pasieka, Anna, Panek, Dawid, Wichur, Tomasz, Więckowski, Krzysztof, Zaręba, Paula, Bajda, Marek, Pislar, Anja, Malawska, Barbara, Sabate, Raimon, Więckowska, Anna
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2020)
Get full text
Journal Article
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
Panek, Dawid, Więckowska, Anna, Wichur, Tomasz, Bajda, Marek, Godyń, Justyna, Jończyk, Jakub, Mika, Kamil, Janockova, Jana, Soukup, Ondrej, Knez, Damijan, Korabecny, Jan, Gobec, Stanislav, Malawska, Barbara
Published in European journal of medicinal chemistry (05.01.2017)
Published in European journal of medicinal chemistry (05.01.2017)
Get full text
Journal Article
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease
Wichur, Tomasz, Więckowska, Anna, Więckowski, Krzysztof, Godyń, Justyna, Jończyk, Jakub, Valdivieso, Álvaro del Río, Panek, Dawid, Pasieka, Anna, Sabaté, Raimon, Knez, Damijan, Gobec, Stanislav, Malawska, Barbara
Published in European journal of medicinal chemistry (01.02.2020)
Published in European journal of medicinal chemistry (01.02.2020)
Get full text
Journal Article
Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and β-amyloid inhibitors for the treatment of Alzheimer’s disease
Pasieka, Anna, Panek, Dawid, Zaręba, Paula, Sługocka, Emilia, Gucwa, Natalia, Espargaró, Alba, Latacz, Gniewomir, Khan, Nadia, Bucki, Adam, Sabaté, Raimon, Więckowska, Anna, Malawska, Barbara
Published in Bioorganic & medicinal chemistry (06.06.2023)
Published in Bioorganic & medicinal chemistry (06.06.2023)
Get full text
Journal Article
Dual Inhibitors of Amyloid‑β and Tau Aggregation with Amyloid‑β Disaggregating Properties: Extended In Cellulo, In Silico, and Kinetic Studies of Multifunctional Anti-Alzheimer’s Agents
Pasieka, Anna, Panek, Dawid, Szałaj, Natalia, Espargaró, Alba, Więckowska, Anna, Malawska, Barbara, Sabaté, Raimon, Bajda, Marek
Published in ACS chemical neuroscience (02.06.2021)
Published in ACS chemical neuroscience (02.06.2021)
Get full text
Journal Article
Multifunctional agents against Alzheimer's disease based on oxidative stress: Polysubstituted pyrazine derivatives synthesized by multicomponent reactions
Wei, Wenxiu, Jing, Lanlan, Tian, Ye, Wieckowska, Anna, Kang, Dongwei, Meng, Bairu, Panek, Dawid, Godyn, Justyna, Goral, Izabella, Song, Yuning, Liu, Xinyong, Zhan, Peng
Published in Bioorganic & medicinal chemistry (15.12.2023)
Published in Bioorganic & medicinal chemistry (15.12.2023)
Get full text
Journal Article
Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors
Panek, Dawid, Wichur, Tomasz, Gody, Justyna, Pasieka, Anna, Malawska, Barbara
Published in Future medicinal chemistry (01.10.2017)
Published in Future medicinal chemistry (01.10.2017)
Get full text
Journal Article
New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Malek, Rim, Arribas, Raquel L, Palomino-Antolin, Alejandra, Totoson, Perle, Demougeot, Celine, Kobrlova, Tereza, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Godyń, Justyna, Panek, Dawid, Malawska, Barbara, Głuch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Chabchoub, Fakher, Marco-Contelles, José, Kiec-Kononowicz, Katarzyna, Egea, Javier, de los Ríos, Cristóbal, Ismaili, Lhassane
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
Get full text
Journal Article
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
Panek, Dawid, Pasieka, Anna, Jończyk, Jakub, Gawlińska, Milena, Zaręba, Paula, Siwek, Agata, Wolak, Małgorzata, Mordyl, Barbara, Głuch-Lutwin, Monika, Latacz, Gniewomir, Brazzolotto, Xavier, Chantegreil, Fabien, Nachon, Florian, Zdarova Karasova, Jana, Pejchal, Jaroslav, Mzik, Martin, Sestak, Vit, Prchal, Lukas, Odvarkova, Jitka, Soukup, Ondrej, Korabecny, Jan, Sorf, Ales, Hamsikova, Marie, Zemanova, Lucie, Muckova, Lubica, Vánova, Nela, Dryja, Pola, Sałat, Kinga, Höfner, Georg, Wanner, Klaus, Więckowska, Anna, Malawska, Barbara
Published in Angewandte Chemie International Edition (11.11.2024)
Published in Angewandte Chemie International Edition (11.11.2024)
Get full text
Journal Article
Discovery of new, highly potent and selective inhibitors of BuChE - design, synthesis, in vitro and in vivo evaluation and crystallography studies
Panek, Dawid, Pasieka, Anna, Latacz, Gniewomir, Zaręba, Paula, Szczęch, Michał, Godyń, Justyna, Chantegreil, Fabien, Nachon, Florian, Brazzolotto, Xavier, Skrzypczak-Wiercioch, Anna, Walczak, Maria, Smolik, Magdalena, Sałat, Kinga, Höfner, Georg, Wanner, Klaus, Więckowska, Anna, Malawska, Barbara
Published in European journal of medicinal chemistry (05.03.2023)
Published in European journal of medicinal chemistry (05.03.2023)
Get full text
Journal Article
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H-3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Malek, Rim, Arribas, Raquel L., Palomino-Antolin, Alejandra, Totoson, Perle, Demougeot, Celine, Kobrlova, Tereza, Soukup, Ondrej, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Godyn, Justyna, Panek, Dawid, Malawska, Barbara, Gluch-Lutwin, Monika, Mordyl, Barbara, Siwek, Agata, Chabchoub, Fakher, Marco-Contelles, Jose, Kiec-Kononowicz, Katarzyna, Egea, Javier, de los Rios, Cristobal, Ismaili, Lhassane
Published in Journal of medicinal chemistry (26.12.2019)
Published in Journal of medicinal chemistry (26.12.2019)
Get full text
Journal Article
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT6 receptor with anti-aggregation properties against amyloid-beta and tau
Wichur, Tomasz, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Góral, Izabella, Latacz, Gniewomir, Honkisz-Orzechowska, Ewelina, Bucki, Adam, Siwek, Agata, Głuch-Lutwin, Monika, Knez, Damijan, Brazzolotto, Xavier, Gobec, Stanislav, Kołaczkowski, Marcin, Sabate, Raimon, Malawska, Barbara, Więckowska, Anna
Published in European journal of medicinal chemistry (05.12.2021)
Published in European journal of medicinal chemistry (05.12.2021)
Get full text
Journal Article
Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer's disease
Zaręba, Paula, Łątka, Kamil, Mazur, Gabriela, Gryzło, Beata, Pasieka, Anna, Godyń, Justyna, Panek, Dawid, Skrzypczak-Wiercioch, Anna, Höfner, Georg C., Latacz, Gniewomir, Maj, Maciej, Espargaró, Alba, Sabaté, Raimon, Jóźwiak, Krzysztof, Wanner, Klaus T., Sałat, Kinga, Malawska, Barbara, Kulig, Katarzyna, Bajda, Marek
Published in European journal of medicinal chemistry (05.12.2023)
Published in European journal of medicinal chemistry (05.12.2023)
Get full text
Journal Article
Discovery of multifunctional anti-Alzheimer’s agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and γ-aminobutyric acid transporters
Pasieka, Anna, Panek, Dawid, Jończyk, Jakub, Godyń, Justyna, Szałaj, Natalia, Latacz, Gniewomir, Tabor, Julia, Mezeiova, Eva, Chantegreil, Fabien, Dias, José, Knez, Damijan, Lu, Junfeng, Pi, Rongbiao, Korabecny, Jan, Brazzolotto, Xavier, Gobec, Stanislav, Höfner, Georg, Wanner, Klaus, Więckowska, Anna, Malawska, Barbara
Published in European journal of medicinal chemistry (05.06.2021)
Published in European journal of medicinal chemistry (05.06.2021)
Get full text
Journal Article