Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
Chauhan, Dharminder, Singh, Ajita, Brahmandam, Mohan, Podar, Klaus, Hideshima, Teru, Richardson, Paul, Munshi, Nikhil, Palladino, Michael A., Anderson, Kenneth C.
Published in Blood (01.02.2008)
Published in Blood (01.02.2008)
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A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells
Singh, Ajita V., Bandi, Madhavi, Raje, Noopur, Richardson, Paul, Palladino, Michael A., Chauhan, Dharminder, Anderson, Kenneth C.
Published in Blood (26.05.2011)
Published in Blood (26.05.2011)
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Pharmacodynamic and efficacy studies of the novel proteasome inhibitor NPI‐0052 (marizomib) in a human plasmacytoma xenograft murine model
Singh, Ajita V., Palladino, Michael A., Lloyd, George Kenneth, Potts, Barbara C., Chauhan, Dharminder, Anderson, Kenneth C.
Published in British journal of haematology (01.05.2010)
Published in British journal of haematology (01.05.2010)
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Journal Article
Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-Independent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells
Sloss, Callum M, Wang, Fang, Liu, Rong, Xia, Lijun, Houston, Michael, Ljungman, David, Palladino, Michael A, Cusack, Jr, James C
Published in Clinical cancer research (15.08.2008)
Published in Clinical cancer research (15.08.2008)
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Journal Article
Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor
Macherla, Venkat R, Mitchell, Scott S, Manam, Rama Rao, Reed, Katherine A, Chao, Ta-Hsiang, Nicholson, Benjamin, Deyanat-Yazdi, Gordafaried, Mai, Bao, Jensen, Paul R, Fenical, William F, Neuteboom, Saskia T. C, Lam, Kin S, Palladino, Michael A, Potts, Barbara C. M
Published in Journal of medicinal chemistry (02.06.2005)
Published in Journal of medicinal chemistry (02.06.2005)
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Journal Article
Myeloid cell leukemia-1 (Mc1-1) is a candidate target gene of hypoxia-inducible factor-1 (HIF-1) in the testis
Palladino, Michael A, Shah, Anoop, Tyson, Rebecca, Horvath, Jaclyn, Dugan, Christine, Karpodinis, Marie
Published in Reproductive biology and endocrinology (05.12.2012)
Published in Reproductive biology and endocrinology (05.12.2012)
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Journal Article
Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
Manam, Rama Rao, McArthur, Katherine A, Chao, Ta-Hsiang, Weiss, Jeffrey, Ali, Janid A, Palombella, Vito J, Groll, Michael, Lloyd, G. Kenneth, Palladino, Michael A, Neuteboom, Saskia T. C, Macherla, Venkat R, Potts, Barbara C. M
Published in Journal of medicinal chemistry (13.11.2008)
Published in Journal of medicinal chemistry (13.11.2008)
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Journal Article
Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes
Traves, Paqui G, Hortelano, Sonsoles, Zeini, Miriam, Chao, Ta-Hsiang, Lam, Thanh, Neuteboom, Saskia T, Theodorakis, Emmanuel A, Palladino, Michael A, Castrillo, Antonio, Bosca, Lisardo
Published in Molecular pharmacology (01.06.2007)
Published in Molecular pharmacology (01.06.2007)
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Journal Article
MicroRNAs downregulated following immune activation of rat testis
Parker, Mitchell I., Palladino, Michael A.
Published in American journal of reproductive immunology (1989) (01.06.2017)
Published in American journal of reproductive immunology (1989) (01.06.2017)
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Journal Article
Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
Chauhan, Dharminder, Singh, Ajita V., Ciccarelli, Bryan, Richardson, Paul G., Palladino, Michael A., Anderson, Kenneth C.
Published in Blood (28.01.2010)
Published in Blood (28.01.2010)
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Journal Article
NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model
CUSACK, James C, RONG LIU, LIJUN XIA, CHAO, Ta-Hsiang, PIEN, Christine, WEI NIU, PALOMBELLA, Vito J, NEUTEBOOM, Saskia T. C, PALLADINO, Michael A
Published in Clinical cancer research (15.11.2006)
Published in Clinical cancer research (15.11.2006)
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Journal Article
Anti-TNF-α therapies: the next generation
Palladino, Michael A, Bahjat, Frances Rena, Theodorakis, Emmanuel A, Moldawer, Lyle L
Published in Nature reviews. Drug discovery (01.09.2003)
Published in Nature reviews. Drug discovery (01.09.2003)
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Journal Article
Enantioselective Synthesis of the Antiinflammatory Agent (−)-Acanthoic Acid
Ling, Taotao, Chowdhury, Chinmay, Kramer, Bryan A, Vong, Binh G, Palladino, Michael A, Theodorakis, Emmanuel A
Published in Journal of organic chemistry (28.12.2001)
Published in Journal of organic chemistry (28.12.2001)
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Journal Article
Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination
Millward, Michael, Price, Timothy, Townsend, Amanda, Sweeney, Christopher, Spencer, Andrew, Sukumaran, Shawgi, Longenecker, Angie, Lee, Lonnie, Lay, Ana, Sharma, Girish, Gemmill, Robert M., Drabkin, Harry A., Lloyd, G. Kenneth, Neuteboom, Saskia T. C., McConkey, David J., Palladino, Michael A., Spear, Matthew A.
Published in Investigational new drugs (01.12.2012)
Published in Investigational new drugs (01.12.2012)
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Journal Article
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib
Chauhan, Dharminder, Catley, Laurence, Li, Guilan, Podar, Klaus, Hideshima, Teru, Velankar, Mugdha, Mitsiades, Constantine, Mitsiades, Nicolas, Yasui, Hiroshi, Letai, Anthony, Ovaa, Huib, Berkers, Celia, Nicholson, Benjamin, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Richardson, Paul, Palladino, Michael A., Anderson, Kenneth C.
Published in Cancer cell (01.11.2005)
Published in Cancer cell (01.11.2005)
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Journal Article
Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products
Ahn, Kwang Seok, Sethi, Gautam, Chao, Ta-Hsiang, Neuteboom, Saskia T.C., Chaturvedi, Madan M., Palladino, Michael A., Younes, Anas, Aggarwal, Bharat B.
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Journal Article
Proteasome Inhibition Activates Epidermal Growth Factor Receptor (EGFR) and EGFR-lndependent Mitogenic Kinase Signaling Pathways in Pancreatic Cancer Cells
SLOSS, Callum M, FANG WANG, RONG LIU, LIJUN XIA, HOUSTON, Michael, LJUNGMAN, David, PALLADINO, Michael A, CUSACK, James C
Published in Clinical cancer research (15.08.2008)
Published in Clinical cancer research (15.08.2008)
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Journal Article
Dual targeting of the proteasome regulates survival and homing in Waldenström macroglobulinemia
Roccaro, Aldo M., Leleu, Xavier, Sacco, Antonio, Jia, Xiaoying, Melhem, Molly, Moreau, Anne-Sophie, Ngo, Hai T., Runnels, Judith, Azab, Abdelkareem, Azab, Feda, Burwick, Nicholas, Farag, Mena, Treon, Steven P., Palladino, Michael A., Hideshima, Teru, Chauhan, Dharminder, Anderson, Kenneth C., Ghobrial, Irene M.
Published in Blood (01.05.2008)
Published in Blood (01.05.2008)
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