Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
Souness, John E., Griffin, Miriam, Maslen, Christopher, Ebsworth, Karen, Scott, Lisa C., Pollock, Kenneth, Palfreyman, Malcolm N., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.06.1996)
Published in British journal of pharmacology (01.06.1996)
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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP‐specific phosphodiesterase: comparison with rolipram
Soilness, John E., Maslen, Christopher, Webber, Stephen, Foster, Martyn, Raeburn, David, Palfreyman, Malcolm N., Ashton, Michael J., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.05.1995)
Published in British journal of pharmacology (01.05.1995)
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Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs
Ashton, Michael J, Cook, David C, Fenton, Garry, Karlsson, Jan-Anders, Palfreyman, Malcolm N, Raeburn, David, Ratcliffe, Andrew J, Souness, John E, Thurairatnam, Suga, Vicker, Nigel
Published in Journal of medicinal chemistry (01.05.1994)
Published in Journal of medicinal chemistry (01.05.1994)
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Syntheses and biological activities of potent potassium channel openers derived from (.+-.)-2-oxo-1-pyridin-3-yl-cyclohexanecarbothioic acid methylamide: new potassium channel openers
Brown, Thomas J, Chapman, Robert F, Mason, Jonathan S, Palfreyman, Malcolm N, Vicker, Nigel, Walsh, Roger J. A
Published in Journal of medicinal chemistry (28.05.1993)
Published in Journal of medicinal chemistry (28.05.1993)
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Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1
CATON, M. P. L, COFFEE, E. C. J, HAMBLING, D. J, HARDY, C. J, PALFREYMAN, M. N
Published in Prostaglandins (01.05.1984)
Published in Prostaglandins (01.05.1984)
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Synthesis and biological activity of trans-(.+-.)-N-methyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogs: a new class of potassium channel opener
Brown, Thomas J, Chapman, Robert F, Cook, David C, Hart, Terance W, McLay, Iain M, Jordan, Roy, Mason, Jonathan S, Palfreyman, Malcolm N, Walsh, Roger J. A
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Synthesis and anti-ulcer activity of 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1
Banerjee, A K, Broughton, B J, Burton, T S, Caton, M P, Christmas, A J, Coffee, E C, Crowshaw, K, Hardy, C J, Heazell, M A, Palfreyman, M N, Parker, T, Saunders, L C, Stuttle, K A
Published in Prostaglandins (01.08.1981)
Published in Prostaglandins (01.08.1981)
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A structural analog of thromboxane A2
Ansell, M F, Caton, M P, Palfreyman, M N, Stuttle, K A, Tuffin, D, Walker, J L
Published in Advances in prostaglandin and thromboxane research (1980)
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Published in Advances in prostaglandin and thromboxane research (1980)
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Representing bioinformatics causality
MANDEL, Johannes, PALFREYMAN, Niall M, LOPEZ, Jesus A, DUBITZKY, Werner
Published in Briefings in bioinformatics (01.09.2004)
Published in Briefings in bioinformatics (01.09.2004)
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Synthesis and biological activity of trans-(±)-N-mehtyl-2-(3-pyridyl)-2-tetrahydrothiopyrancarbothioamide 1-oxide (RP 49356) and analogues : a new class of potassium channel opener
BROWN, T. J, CHAPMAN, R. F, ALOUP, J.-C, CAVERO, I, FARGE, D, JAMES, C, MONDOT, S, COOK, D. C, HART, T. W, MCLAY, I. M, JORDAN, R, MASON, J. S, PALFREYMAN, M. N, WALSH, R. J. A, WITHNALL, M. T
Published in Journal of medicinal chemistry (1992)
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Published in Journal of medicinal chemistry (1992)
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Studies related to cyclopentanoid natural products. II: An improved route to (4R)-4-hydroxy-2-hydroxymethylcyclopent-2-en-1-one and its O-substituted derivatives
ELLIOTT, J. D, KELSON, A. B, PURCELL, N, STOODLEY, R. J, PALFREYMAN, M. N
Published in Perkin transactions. 1 (1983)
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Published in Perkin transactions. 1 (1983)
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4-Hydroxy-2-hydroxymethylcyclopent-2-en-1-one: a versatile intermediate for the synthesis of cyclopentanoid natural products
Elliott, John D., Hetmanski, Michael, Stoodley, Richard J., Palfreyman, Malcolm N.
Published in Journal of the Chemical Society. Chemical communications (1980)
Published in Journal of the Chemical Society. Chemical communications (1980)
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