The role of dimer asymmetry and protomer dynamics in enzyme catalysis
Kim, Tae Hun, Mehrabi, Pedram, Ren, Zhong, Sljoka, Adnan, Ing, Christopher, Bezginov, Alexandr, Ye, Libin, Pomès, Régis, Prosser, R. Scott, Pai, Emil F.
Published in Science (American Association for the Advancement of Science) (20.01.2017)
Published in Science (American Association for the Advancement of Science) (20.01.2017)
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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Ishizawa, Jo, Zarabi, Sarah F., Davis, R. Eric, Halgas, Ondrej, Nii, Takenobu, Jitkova, Yulia, Zhao, Ran, St-Germain, Jonathan, Heese, Lauren E., Egan, Grace, Ruvolo, Vivian R., Barghout, Samir H., Nishida, Yuki, Hurren, Rose, Ma, Wencai, Gronda, Marcela, Link, Todd, Wong, Keith, Mabanglo, Mark, Kojima, Kensuke, Borthakur, Gautam, MacLean, Neil, Ma, Man Chun John, Leber, Andrew B., Minden, Mark D., Houry, Walid, Kantarjian, Hagop, Stogniew, Martin, Raught, Brian, Pai, Emil F., Schimmer, Aaron D., Andreeff, Michael
Published in Cancer cell (13.05.2019)
Published in Cancer cell (13.05.2019)
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Allopurinol and oxypurinol differ in their strength and mechanisms of inhibition of xanthine oxidoreductase
Sekine, Mai, Okamoto, Ken, Pai, Emil F., Nagata, Koji, Ichida, Kimiyoshi, Hille, Russ, Nishino, Takeshi
Published in The Journal of biological chemistry (01.09.2023)
Published in The Journal of biological chemistry (01.09.2023)
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Hydrophobic Gating of Ion Permeation in Magnesium Channel CorA
Neale, Chris, Chakrabarti, Nilmadhab, Pomorski, Pawel, Pai, Emil F, Pomès, Régis
Published in PLoS computational biology (01.07.2015)
Published in PLoS computational biology (01.07.2015)
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Journal Article
Crystal structure of metarhodopsin II
Choe, Hui-Woog, Kim, Yong Ju, Park, Jung Hee, Morizumi, Takefumi, Pai, Emil F., Krauß, Norbert, Hofmann, Klaus Peter, Scheerer, Patrick, Ernst, Oliver P.
Published in Nature (London) (31.03.2011)
Published in Nature (London) (31.03.2011)
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Mammalian xanthine oxidoreductase - mechanism of transition from xanthine dehydrogenase to xanthine oxidase
Nishino, Tomoko, Okamoto, Ken, Eger, Bryan T, Pai, Emil F, Nishino, Takeshi
Published in The FEBS journal (01.07.2008)
Published in The FEBS journal (01.07.2008)
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Time-resolved crystallography reveals allosteric communication aligned with molecular breathing
Mehrabi, Pedram, Schulz, Eike C, Dsouza, Raison, Müller-Werkmeister, Henrike M, Tellkamp, Friedjof, Miller, R J Dwayne, Pai, Emil F
Published in Science (American Association for the Advancement of Science) (13.09.2019)
Published in Science (American Association for the Advancement of Science) (13.09.2019)
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The hit-and-return system enables efficient time-resolved serial synchrotron crystallography
Schulz, Eike C., Mehrabi, Pedram, Müller-Werkmeister, Henrike M., Tellkamp, Friedjof, Jha, Ajay, Stuart, William, Persch, Elke, De Gasparo, Raoul, Diederich, François, Pai, Emil F., Miller, R. J. Dwayne
Published in Nature methods (01.11.2018)
Published in Nature methods (01.11.2018)
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Substrate-Based Allosteric Regulation of a Homodimeric Enzyme
Mehrabi, Pedram, Di Pietrantonio, Christopher, Kim, Tae Hun, Sljoka, Adnan, Taverner, Keith, Ing, Christopher, Kruglyak, Natasha, Pomès, Régis, Pai, Emil F, Prosser, R. Scott
Published in Journal of the American Chemical Society (24.07.2019)
Published in Journal of the American Chemical Society (24.07.2019)
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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia
Barghout, Samir H., Patel, Parasvi S., Wang, Xiaoming, Xu, G. Wei, Kavanagh, Simon, Halgas, Ondrej, Zarabi, Sara F., Gronda, Marcela, Hurren, Rose, Jeyaraju, Danny V., MacLean, Neil, Brennan, Shawn, Hyer, Marc L., Berger, Allison, Traore, Tary, Milhollen, Michael, Smith, Adam C., Minden, Mark D., Pai, Emil F., Hakem, Razq, Schimmer, Aaron D.
Published in Leukemia (01.01.2019)
Published in Leukemia (01.01.2019)
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Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase
Kanjee, Usheer, Gutsche, Irina, Alexopoulos, Eftichia, Zhao, Boyu, El Bakkouri, Majida, Thibault, Guillaume, Liu, Kaiyin, Ramachandran, Shaliny, Snider, Jamie, Pai, Emil F, Houry, Walid A
Published in The EMBO journal (02.03.2011)
Published in The EMBO journal (02.03.2011)
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Journal Article
C‐terminal peptide plays a role in the formation of an intermediate form during the transition between xanthine dehydrogenase and xanthine oxidase
Nishino, Tomoko, Okamoto, Ken, Kawaguchi, Yuko, Matsumura, Tomohiro, Eger, Bryan T, Pai, Emil F, Nishino, Takeshi
Published in The FEBS journal (01.08.2015)
Published in The FEBS journal (01.08.2015)
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Journal Article
An Iris-Like Mechanism of Pore Dilation in the CorA Magnesium Transport System
Chakrabarti, Nilmadhab, Neale, Chris, Payandeh, Jian, Pai, Emil F., Pomès, Régis
Published in Biophysical journal (03.03.2010)
Published in Biophysical journal (03.03.2010)
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Journal Article
Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase
De Gasparo, Raoul, Halgas, Ondrej, Harangozo, Dora, Kaiser, Marcel, Pai, Emil F., Krauth‐Siegel, R. Luise, Diederich, François
Published in Chemistry : a European journal (02.09.2019)
Published in Chemistry : a European journal (02.09.2019)
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Prion disease susceptibility is affected by β-structure folding propensity and local side-chain interactions in PrP
Khan, M. Qasim, Sweeting, Braden, Mulligan, Vikram Khipple, Arslan, Pharhad Eli, Cashman, Neil R., Pai, Emil F., Chakrabartty, Avijit, Baldwin, Robert
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (16.11.2010)
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Computational Design of High-Affinity Epitope Scaffolds by Backbone Grafting of a Linear Epitope
Azoitei, Mihai L., Ban, Yih-En Andrew, Julien, Jean-Philippe, Bryson, Steve, Schroeter, Alexandria, Kalyuzhniy, Oleksandr, Porter, Justin R., Adachi, Yumiko, Baker, David, Pai, Emil F., Schief, William R.
Published in Journal of molecular biology (06.01.2012)
Published in Journal of molecular biology (06.01.2012)
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