A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
Lim, Hyejin, Lim, Yu-Mi, Kim, Kook Hwan, Jeon, Young Eui, Park, Kihyoun, Kim, Jinyoung, Hwang, Hui-Yun, Lee, Dong Jin, Pagire, Haushabhau, Kwon, Ho Jeong, Ahn, Jin Hee, Lee, Myung-Shik
Published in Nature communications (12.04.2018)
Published in Nature communications (12.04.2018)
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Journal Article
Inhibition of HTR2B-mediated serotonin signaling in colorectal cancer suppresses tumor growth through ERK signaling
Lee, Jeong-Yun, Park, Suhyeon, Park, Eun Jung, Pagire, Haushabhau S., Pagire, Suvarna H., Choi, Byeong-Wook, Park, Moonyoung, Fang, Sungsoon, Ahn, Jin Hee, Oh, Chang-Myung
Published in Biomedicine & pharmacotherapy (01.10.2024)
Published in Biomedicine & pharmacotherapy (01.10.2024)
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Journal Article
PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
Kim, Juhee, Jeon, Yujin, Son, Jinyoung, Pagire, Haushabhau S., Pagire, Suvarna H., Ahn, Jin Hee, Uemura, Akiyoshi, Lee, In-Kyu, Park, Sungmi, Park, Dong Ho
Published in Cell death & disease (09.08.2024)
Published in Cell death & disease (09.08.2024)
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Journal Article
Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
Oh, Chang Joo, Kim, Min-Ji, Lee, Ji-Min, Kim, Dong Hun, Kim, Il-Young, Park, Sanghee, Kim, Yeongmin, Lee, Kyung-Bok, Lee, Sang-Hee, Lim, Chae Won, Kim, Myeongjin, Lee, Jung-Yi, Pagire, Haushabhau S., Pagire, Suvarna H., Bae, Myung Ae, Chanda, Dipanjan, Thoudam, Themis, Khang, Ah Reum, Harris, Robert A., Ahn, Jin Hee, Jeon, Jae-Han, Lee, In-Kyu
Published in Kidney international (01.10.2023)
Published in Kidney international (01.10.2023)
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Journal Article
Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis
Pagire, Haushabhau S., Pagire, Suvarna H., Jeong, Byung-kwan, Choi, Won-Il, Oh, Chang Joo, Lim, Chae Won, Kim, Minhee, Yoon, Jihyeon, Kim, Seong Soon, Bae, Myung Ae, Jeon, Jae-Han, Song, Sungmin, Lee, Hee Jong, Lee, Eun Young, Goughnour, Peter C., Kim, Dooseop, Lee, In-Kyu, Loomba, Rohit, Kim, Hail, Ahn, Jin Hee
Published in Nature communications (20.01.2024)
Published in Nature communications (20.01.2024)
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Journal Article
ENOblock inhibits the pathology of diet-induced obesity
Cho, Haaglim, Lee, Ji-Hyung, Um, JungIn, Kim, Sunwook, Kim, Yukyung, Kim, Woong-Hee, Kim, Yong Sook, Pagire, Haushabhau S., Ahn, Jin Hee, Ahn, Youngkeun, Chang, Young-Tae, Jung, Da-Woon, Williams, Darren R.
Published in Scientific reports (24.01.2019)
Published in Scientific reports (24.01.2019)
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Journal Article
Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle
Lee, Narasaem, Lim, Bong Hee, Lee, Kyu-Sung, Shin, Jimin, Pagire, Haushabhau S, Pagire, Suvarna H, Ahn, Jin Hee, Lee, Sung Won, Kang, Tong Mook, Park, Chul-Seung
Published in Molecular pharmacology (01.02.2021)
Published in Molecular pharmacology (01.02.2021)
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Journal Article
Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2A receptor antagonists for nonalcoholic fatty liver disease
Kim, Minhee, Choi, Wonil, Yoon, Jihyeon, Jeong, Byung-kwan, Pagire, Suvarna H., Pagire, Haushabhau S., Park, Jungsun, Nam, Jung Eun, Oh, Chang Joo, Jeon, Jae-Han, Kim, Seong Soon, Lee, Byung Hoi, Song, Jin Sook, Bae, Myung Ae, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee
Published in European journal of medicinal chemistry (05.09.2022)
Published in European journal of medicinal chemistry (05.09.2022)
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Journal Article
Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds
Kang, Jihoon, Pagire, Haushabhau S., Kang, Donguk, Song, Yo Han, Lee, In Kyu, Lee, Kang Taek, Park, Chin-Ju, Ahn, Jin Hee, Kim, Jungwook
Published in Biochemical and biophysical research communications (30.06.2020)
Published in Biochemical and biophysical research communications (30.06.2020)
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Journal Article
Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease
Pagire, Suvarna H, Pagire, Haushabhau S, Park, Kun-Young, Bae, Eun Jung, Kim, Kwang-Eun, Kim, Minhee, Yoon, Jihyeon, Parameswaran, Saravanan, Choi, Jun-Ho, Park, Sungmi, Jeon, Jae-Han, Song, Jin Sook, Bae, Myung Ae, Lee, In-Kyu, Kim, Hail, Suh, Jae Myoung, Ahn, Jin Hee
Published in Molecules (Basel, Switzerland) (25.05.2022)
Published in Molecules (Basel, Switzerland) (25.05.2022)
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Journal Article
Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease
Bae, Eun Jung, Choi, Won Gun, Pagire, Haushabhau S, Pagire, Suvarna H, Parameswaran, Saravanan, Choi, Jun-Ho, Yoon, Jihyeon, Choi, Won-il, Lee, Ji Hun, Song, Jin Sook, Bae, Myung Ae, Kim, Mijin, Jeon, Jae-Han, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee
Published in Journal of medicinal chemistry (28.01.2021)
Published in Journal of medicinal chemistry (28.01.2021)
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Journal Article
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents
Kwak, Hyun Jung, Pyun, Yu Mi, Kim, Ji Young, Pagire, Haushabhau S., Kim, Ki Young, Kim, Kwang Rok, Rhee, Sang Dal, Jung, Won Hoon, Song, Jin Sook, Bae, Myung Ae, Lee, Duck Hyung, Ahn, Jin Hee
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease
Kim, Minhee, Hwang, Inseon, Pagire, Haushabhau S, Pagire, Suvarna H, Choi, Wonsuk, Choi, Won Gun, Yoon, Jihyeon, Lee, Won Mi, Song, Jin Sook, Yoo, Eun Kyung, Lee, Seung Mi, Kim, Mi-jin, Bae, Myung Ae, Kim, Dooseop, Lee, Heejong, Lee, Eun-Young, Jeon, Jae-Han, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases
Lee, Dahye, Pagire, Haushabhau S, Pagire, Suvarna H, Bae, Eun Jung, Dighe, Mahesh, Kim, Minhee, Lee, Kyu Myung, Jang, Yoon Kyung, Jaladi, Ashok Kumar, Jung, Kwan-Young, Yoo, Eun Kyung, Gim, Hee Eon, Lee, Seungmi, Choi, Won-Il, Chi, Young-In, Song, Jin Sook, Bae, Myung Ae, Jeon, Yong Hyun, Lee, Ga-Hyun, Liu, Kwang-Hyeon, Lee, Taeho, Park, Sungmi, Jeon, Jae-Han, Lee, In-Kyu, Ahn, Jin Hee
Published in Journal of medicinal chemistry (24.01.2019)
Published in Journal of medicinal chemistry (24.01.2019)
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Journal Article
Optimization of cyclic sulfamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury
Lee, Jeong Hyun, Bok, Ju Hwan, Park, Sung Bum, Pagire, Haushabhau S., Na, Yoon-Ju, Rim, Eunyoung, Jung, Won Hoon, Song, Jin Sook, Kang, Nam Sook, Seo, Ho Won, Jung, Kwan-Young, Lee, Byung Ho, Kim, Ki Young, Ahn, Jin Hee
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
Published in Bioorganic & medicinal chemistry letters (15.01.2020)
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Journal Article
Design, Synthesis, and Biological Evaluation of New Peripheral 5HT 2A Antagonists for Nonalcoholic Fatty Liver Disease
Kim, Minhee, Hwang, Inseon, Pagire, Haushabhau S, Pagire, Suvarna H, Choi, Wonsuk, Choi, Won Gun, Yoon, Jihyeon, Lee, Won Mi, Song, Jin Sook, Yoo, Eun Kyung, Lee, Seung Mi, Kim, Mi-Jin, Bae, Myung Ae, Kim, Dooseop, Lee, Heejong, Lee, Eun-Young, Jeon, Jae-Han, Lee, In-Kyu, Kim, Hail, Ahn, Jin Hee
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Journal Article
Activation mechanism and novel binding sites of the BKCa channel activator CTIBD
Lee, Narasaem, Kim, Subin, Lee, Na Young, Jo, Heeji, Jeong, Pyeonghwa, Pagire, Haushabhau S, Pagire, Suvarna H, Ahn, Jin Hee, Jin, Mi Sun, Park, Chul-Seung
Published in Life science alliance (01.10.2024)
Published in Life science alliance (01.10.2024)
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Journal Article
Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation
Lee, Hoyul, Jeon, Jae Han, Lee, Yu-Jeong, Kim, Mi-Jin, Kwon, Woong Hee, Chanda, Dipanjan, Thoudam, Themis, Pagire, Haushabhau S., Pagire, Suvarna H., Ahn, Jin Hee, Harris, Robert A., Kim, Eun Soo, Lee, In-Kyu
Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
Published in Cellular and molecular gastroenterology and hepatology (01.01.2023)
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Journal Article
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists
Jang, Yoon Kyung, Lee, Kyu Myung, Jung, Kwan-Young, Kang, Seung Kyu, Pagire, Suvarna H., Lee, Jun Mi, Pagire, Haushabhau S., Kim, Kwang Rok, Bae, Myung Ae, Lee, Hohjai, Rhee, Sang Dal, Ahn, Jin Hee
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
Published in Bioorganic & medicinal chemistry letters (15.08.2017)
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Journal Article