Time dependent analysis of assay comparability: a novel approach to understand intra- and inter-site variability over time
Winiwarter, Susanne, Middleton, Brian, Jones, Barry, Courtney, Paul, Lindmark, Bo, Page, Ken M., Clark, Alan, Landqvist, Claire
Published in Journal of computer-aided molecular design (01.09.2015)
Published in Journal of computer-aided molecular design (01.09.2015)
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Hydantoin based inhibitors of MMP13—Discovery of AZD6605
De Savi, Chris, Waterson, David, Pape, Andrew, Lamont, Scott, Hadley, Elma, Mills, Mark, Page, Ken M., Bowyer, Jonathan, Maciewicz, Rose A.
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Pharmacokinetic Benefits of 3,4-Dimethoxy Substitution of a Phenyl Ring and Design of Isosteres Yielding Orally Available Cathepsin K Inhibitors
Crawford, James J, Kenny, Peter W, Bowyer, Jonathan, Cook, Calum R, Finlayson, Jonathan E, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McDermott, Benjamin P, McGuire, Thomas M, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Dossetter, Alexander G
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition
Dossetter, Alexander G., Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Krapp, Stephan, MacFaul, Philip A., McGuire, Thomas M., Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis
Dossetter, Alexander G, Beeley, Howard, Bowyer, Jonathan, Cook, Calum R, Crawford, James J, Finlayson, Jonathan E, Heron, Nicola M, Heyes, Christine, Highton, Adrian J, Hudson, Julian A, Jestel, Anja, Kenny, Peter W, Krapp, Stephan, Martin, Scott, MacFaul, Philip A, McGuire, Thomas M, Gutierrez, Pablo Morentin, Morley, Andrew D, Morris, Jeffrey J, Page, Ken M, Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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Aminoimidazolylmethyluracil Analogues as Potent Inhibitors of Thymidine Phosphorylase and Their Bioreductive Nitroimidazolyl Prodrugs
Reigan, Philip, Edwards, Philip N, Gbaj, Abdul, Cole, Christian, Barry, Simon T, Page, Ken M, Ashton, Susan E, Luke, Richard W. A, Douglas, Kenneth T, Stratford, Ian J, Jaffar, Mohammed, Bryce, Richard A, Freeman, Sally
Published in Journal of medicinal chemistry (27.01.2005)
Published in Journal of medicinal chemistry (27.01.2005)
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(1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b)indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis
Dossetter, Alexander G., Beeley, Howard, Bowyer, Jonathan, Cook, Calum R., Crawford, James J., Finlayson, Jonathan E., Heron, Nicola M., Heyes, Christine, Highton, Adrian J., Hudson, Julian A., Jestel, Anja, Kenny, Peter W., Krapp, Stephan, Martin, Scott, MacFaul, Philip A., McGuire, Thomas M., Gutierrez, Pablo Morentin, Morley, Andrew D., Morris, Jeffrey J., Page, Ken M., Ribeiro, Lyn Rosenbrier, Sawney, Helen, Steinbacher, Stefan, Smith, Caroline, Vickers, Madeleine
Published in Journal of medicinal chemistry (26.07.2012)
Published in Journal of medicinal chemistry (26.07.2012)
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Multiple surface plasmon resonance quantification of dextromethorphan using a molecularly imprinted β-cyclodextrin polymer: A potential probe for drug–drug interactions
Roche, Philip J.R., Ng, Sing Muk, Narayanaswamy, Ramaier, Goddard, Nicholas, Page, Ken M.
Published in Sensors and actuators. B, Chemical (20.05.2009)
Published in Sensors and actuators. B, Chemical (20.05.2009)
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Abstract 4478: Discovery of AZD5363, an orally bioavailable, potent ATP-competitive inhibitor of AKT kinases
Luke, Richard W., Addie, Matthew, Box, Matthew R., Buttar, David, Crafter, Claire, Currie, Gordon S., Cosulich, Sabina C., Davies, Barry, Dudley, Philippa G., Greenwood, Ryan, Johnson, Paul D., Greenwood, Hannah, Lamont, Gillian M., Lane, Clare, Page, Ken M., Pearson, Stuart E., Ruston, Linette
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I
Hulme, Christopher, Moriarty, Kevin, Miller, Bruce, Mathew, Rose, Ramanjulu, Mercy, Cox, Paul, Souness, John, Page, Ken M., Uhl, Joanne, Travis, Jeffrey, Huang, Fu-chih, Labaudiniere, Richard, Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (21.07.1998)
Published in Bioorganic & medicinal chemistry letters (21.07.1998)
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Orally active indole N-oxide PDE4 inhibitors
Hulme, Christopher, Mathew, Rose, Moriarty, Kevin, Miller, Bruce, Ramanjulu, Mercy, Cox, Paul, Souness, John, Page, Ken M., Uhl, Joanne, Travis, Jeffrey, Labaudiniere, Richard, Huang, Fu-chih, Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
Published in Bioorganic & medicinal chemistry letters (03.11.1998)
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