Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
Zhang, Xiaolei, Yue, Peibin, Page, Brent D. G, Li, Tianshu, Zhao, Wei, Namanja, Andrew T, Paladino, David, Zhao, Jihe, Chen, Yuan, Gunning, Patrick T, Turkson, James
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Get full text
Journal Article
The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
Qian, Jing, Ma, Yanxia, Tahaney, William M, Moyer, Cassandra L, Lanier, Amanda, Hill, Jamal, Coleman, Darian, Koupaei, Negar, Hilsenbeck, Susan G, Savage, Michelle I, Page, Brent D G, Mazumdar, Abhijit, Brown, Powel H
Published in Breast cancer research : BCR (05.02.2024)
Published in Breast cancer research : BCR (05.02.2024)
Get full text
Journal Article
Correction: The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
Qian, Jing, Ma, Yanxia, Tahaney, William M, Moyer, Cassandra L, Lanier, Amanda, Hill, Jamal, Coleman, Darian, Koupaei, Negar, Hilsenbeck, Susan G, Savage, Michelle I, Page, Brent D G, Mazumdar, Abhijit, Brown, Powel H
Published in Breast cancer research : BCR (26.03.2024)
Published in Breast cancer research : BCR (26.03.2024)
Get full text
Journal Article
Signal transducer and activator of transcription 3 inhibitors: a patent review
Page, Brent D G, Ball, Daniel P, Gunning, Patrick T
Published in Expert opinion on therapeutic patents (01.01.2011)
Published in Expert opinion on therapeutic patents (01.01.2011)
Get more information
Journal Article
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko, Iryna, Yu, Yasmin, Busker, Sander, Dyczynski, Matheus, Liu, Jianping, Haraldsson, Martin, Palm Apergi, Caroline, Helleday, Thomas, Tamm, Katja Pokrovskaja, Page, Brent D G, Grander, Dan
Published in PloS one (21.06.2017)
Published in PloS one (21.06.2017)
Get full text
Journal Article
Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma
Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O, Veloso, Anthony J, Page, Brent D. G, Cheng, Xin Ran, Dawson, Sean S, Grinshtein, Natalie, Shahani, Vijay M, Kerman, Kagan, Kaplan, David R, Griffin, Carly, Aman, Ahmed M, Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
Get full text
Journal Article
Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity
Brown, Jennifer I, Wang, Peng, Wong, Alan Y L, Petrova, Boryana, Persaud, Rosanne, Soukhtehzari, Sepideh, Lopez McDonald, Melanie, Hanke, Danielle, Christensen, Josephine, Iliev, Petar, Wang, Weiyuan, Everton, Daniel K, Williams, Karla C, Frank, David A, Kanarek, Naama, Page, Brent D G
Published in Metabolites (19.01.2023)
Published in Metabolites (19.01.2023)
Get full text
Journal Article
Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
Page, Brent D.G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Datti, Alessandro, Wrana, Jeffrey L., Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Get full text
Journal Article
Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Published in Nature communications (04.08.2015)
Published in Nature communications (04.08.2015)
Get full text
Journal Article
Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (17.01.2018)
Published in Nature communications (17.01.2018)
Get full text
Journal Article
Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases
Adhikary, Partho Protim, Idowu, Temilolu, Tan, Zheng, Hoang, Christopher, Shanta, Selina, Dumbani, Malti, Mappalakayil, Leah, Awasthi, Bhuwan, Bermudez, Marcel, Weiner, January, Beule, Dieter, Wolber, Gerhard, Page, Brent DG, Hedtrich, Sarah
Published in EMBO molecular medicine (15.07.2024)
Published in EMBO molecular medicine (15.07.2024)
Get full text
Journal Article
Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition
Pons, Miriam, Zeyn, Yanira, Zahn, Stella, Mahendrarajah, Nisintha, Page, Brent D G, Gunning, Patrick T, Moriggl, Richard, Brenner, Walburgis, Butter, Falk, Krämer, Oliver H
Published in Cancers (10.07.2021)
Published in Cancers (10.07.2021)
Get full text
Journal Article
Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays
Attarha, Sanaz, Reithmeier, Anja, Busker, Sander, Desroses, Matthieu, Page, Brent D. G
Published in ACS chemical biology (17.07.2020)
Published in ACS chemical biology (17.07.2020)
Get full text
Journal Article
Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia
Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W
Published in Leukemia (01.03.2015)
Published in Leukemia (01.03.2015)
Get full text
Journal Article
Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity
Page, Brent D. G, Khoury, Haytham, Laister, Rob C, Fletcher, Steven, Vellozo, Megan, Manzoli, Alessia, Yue, Peibin, Turkson, James, Minden, Mark D, Gunning, Patrick T
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
Get full text
Journal Article
Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer
Lai, Andrea Z, Cory, Sean, Zhao, Hong, Gigoux, Mathieu, Monast, Anie, Guiot, Marie-Christine, Huang, Sidong, Tofigh, Ali, Thompson, Crista, Naujokas, Monica, Marcus, Victoria A, Bertos, Nicholas, Sehat, Bita, Perera, Rushika M, Bell, Emily S, Page, Brent D G, Gunning, Patrick T, Ferri, Lorenzo E, Hallett, Michael, Park, Morag
Published in Science signaling (22.04.2014)
Published in Science signaling (22.04.2014)
Get more information
Journal Article
Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (01.11.2019)
Published in Nature communications (01.11.2019)
Get full text
Journal Article
Inhibiting Aberrant Signal Transducer and Activator of Transcription Protein Activation with Tetrapodal, Small Molecule Src Homology 2 Domain Binders: Promising Agents against Multiple Myeloma
Page, Brent D. G, Croucher, Danielle C, Li, Zhi Hua, Haftchenary, Sina, Jimenez-Zepeda, Victor H, Atkinson, Jennifer, Spagnuolo, Paul A, Wong, Yoong Lim, Colaguori, Robert, Lewis, Andrew M, Schimmer, Aaron D, Trudel, Suzanne, Gunning, Patrick T
Published in Journal of medicinal chemistry (26.09.2013)
Published in Journal of medicinal chemistry (26.09.2013)
Get full text
Journal Article