NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Valerie, Nicholas C K, Hagenkort, Anna, Page, Brent D G, Masuyer, Geoffrey, Rehling, Daniel, Carter, Megan, Bevc, Luka, Herr, Patrick, Homan, Evert, Sheppard, Nina G, Stenmark, Pål, Jemth, Ann-Sofie, Helleday, Thomas
Published in Cancer research (Chicago, Ill.) (15.09.2016)
Published in Cancer research (Chicago, Ill.) (15.09.2016)
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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas
Published in Nature communications (2018)
Published in Nature communications (2018)
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STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
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Published in Journal of pharmaceutical and biomedical analysis (25.10.2018)
Published in Journal of pharmaceutical and biomedical analysis (25.10.2018)
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An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery
Mitra, Rajendra N, Doshi, Mona, Zhang, Xiaolei, Tyus, Jessica C, Bengtsson, Niclas, Fletcher, Steven, Page, Brent D.G, Turkson, James, Gesquiere, Andre J, Gunning, Patrick T, Walter, Glenn A, Santra, Swadeshmukul
Published in Biomaterials (01.02.2012)
Published in Biomaterials (01.02.2012)
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Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain
Page, Brent D.G., Fletcher, Steven, Yue, Peibin, Li, Zhihua, Zhang, Xiaolei, Sharmeen, Sumaiya, Datti, Alessandro, Wrana, Jeffrey L., Trudel, Suzanne, Schimmer, Aaron D., Turkson, James, Gunning, Patrick T.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Disruption of Transcriptionally Active Stat3 Dimers with Non-phosphorylated, Salicylic Acid-Based Small Molecules: Potent in vitro and Tumor Cell Activities
Fletcher, Steven, Singh, Jardeep, Zhang, Xiaolei, Yue, Peibin, Page, Brent D.G, Sharmeen, Sumaiya, Shahani, Vijay M, Zhao, Wei, Schimmer, Aaron D, Turkson, James, Gunning, Patrick T
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
Published in Chembiochem : a European journal of chemical biology (17.08.2009)
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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts
Zhang, Xiaolei, Yue, Peibin, Page, Brent D. G, Li, Tianshu, Zhao, Wei, Namanja, Andrew T, Paladino, David, Zhao, Jihe, Chen, Yuan, Gunning, Patrick T, Turkson, James
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2012)
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Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Herold, Nikolas, Rudd, Sean G, Ljungblad, Linda, Sanjiv, Kumar, Myrberg, Ida Hed, Paulin, Cynthia B J, Heshmati, Yaser, Hagenkort, Anna, Kutzner, Juliane, Page, Brent D G, Calderón-Montaño, José M, Loseva, Olga, Jemth, Ann-Sofie, Bulli, Lorenzo, Axelsson, Hanna, Tesi, Bianca, Valerie, Nicholas C K, Höglund, Andreas, Bladh, Julia, Wiita, Elisée, Sundin, Mikael, Uhlin, Michael, Rassidakis, Georgios, Heyman, Mats, Tamm, Katja Pokrovskaja, Warpman-Berglund, Ulrika, Walfridsson, Julian, Lehmann, Sören, Grandér, Dan, Lundbäck, Thomas, Kogner, Per, Henter, Jan-Inge, Helleday, Thomas, Schaller, Torsten
Published in Nature medicine (01.02.2017)
Published in Nature medicine (01.02.2017)
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The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase
Heppler, Lisa N., Attarha, Sanaz, Persaud, Rosanne, Brown, Jennifer I., Wang, Peng, Petrova, Boryana, Tošić, Isidora, Burton, Foster B., Flamand, Yael, Walker, Sarah R., Yeh, Jennifer E., Zubarev, Roman A., Gaetani, Massimiliano, Kanarek, Naama, Page, Brent D.G., Frank, David A.
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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Investigating Protein Binding with the Isothermal Ligand‐induced Resolubilization Assay
Prout‐Holm, Riley A., Walstijn, Cerissa C., Hitsman, Alana, Rowley, Michael J., Olsen, Jonas E., Page, Brent D. G., Frankel, Adam
Published in Chembiochem : a European journal of chemical biology (15.03.2024)
Published in Chembiochem : a European journal of chemical biology (15.03.2024)
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Validating Signal Transducer and Activator of Transcription (STAT) Protein–Inhibitor Interactions Using Biochemical and Cellular Thermal Shift Assays
Attarha, Sanaz, Reithmeier, Anja, Busker, Sander, Desroses, Matthieu, Page, Brent D. G
Published in ACS chemical biology (17.07.2020)
Published in ACS chemical biology (17.07.2020)
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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2
Carter, Megan, Jemth, Ann-Sofie, Hagenkort, Anna, Page, Brent D. G., Gustafsson, Robert, Griese, Julia J., Gad, Helge, Valerie, Nicholas C. K., Desroses, Matthieu, Boström, Johan, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål
Published in Nature communications (04.08.2015)
Published in Nature communications (04.08.2015)
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The novel phosphatase NUDT5 is a critical regulator of triple-negative breast cancer growth
Qian, Jing, Ma, Yanxia, Tahaney, William M, Moyer, Cassandra L, Lanier, Amanda, Hill, Jamal, Coleman, Darian, Koupaei, Negar, Hilsenbeck, Susan G, Savage, Michelle I, Page, Brent D G, Mazumdar, Abhijit, Brown, Powel H
Published in Breast cancer research : BCR (05.02.2024)
Published in Breast cancer research : BCR (05.02.2024)
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Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens
Brown, Jennifer I., Persaud, Rosanne, Iliev, Petar, Karmacharya, Ujjwala, Attarha, Sanaz, Sahile, Henok, Olsen, Jonas E., Hanke, Danielle, Idowu, Temilolu, Frank, David A., Frankel, Adam, Williams, Karla C., Page, Brent D. G.
Published in European journal of medicinal chemistry (15.01.2024)
Published in European journal of medicinal chemistry (15.01.2024)
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TSLP as druggable target – a silver-lining for atopic diseases?
Adhikary, Partho Protim, Tan, Zheng, Page, Brent D.G., Hedtrich, Sarah
Published in Pharmacology & therapeutics (Oxford) (01.01.2021)
Published in Pharmacology & therapeutics (Oxford) (01.01.2021)
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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas
Published in Cell chemical biology (16.12.2021)
Published in Cell chemical biology (16.12.2021)
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Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity
Page, Brent D. G, Khoury, Haytham, Laister, Rob C, Fletcher, Steven, Vellozo, Megan, Manzoli, Alessia, Yue, Peibin, Turkson, James, Minden, Mark D, Gunning, Patrick T
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Journal Article
Development of a chemical probe against NUDT15
Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas
Published in Nature chemical biology (01.10.2020)
Published in Nature chemical biology (01.10.2020)
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