Metabolism, Excretion, and Pharmacokinetics of [14 C]-Radiolabeled Aleglitazar: A Phase I, Nonrandomized, Open-Label, Single-Center, Single-Dose Study in Healthy Male Volunteers
Sturm, Stefan, PhD, Seiberling, Michael, MD, Weick, Idelette, MSc, Paehler, Axel, PhD, Funk, Christoph, PhD, Ruf, Thorsten, MD
Published in Clinical therapeutics (01.02.2012)
Published in Clinical therapeutics (01.02.2012)
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Journal Article
Analysis and Quantification of DNA Adducts of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Liver of Rats by Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paehler, Axel, Richoz, Janique, Soglia, John, Vouros, Paul, Turesky, Robert J
Published in Chemical research in toxicology (01.04.2002)
Published in Chemical research in toxicology (01.04.2002)
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Journal Article
Quantification of the Heterocyclic Aromatic Amine DNA Adduct N-(Deoxyguanosin-8-yl)-2-amino-3-methylimidazo[4,5-f]quinoline in Livers of Rats Using Capillary Liquid Chromatography/Microelectrospray Mass Spectrometry: A Dose−Response Study
Soglia, John R, Turesky, Robert J, Paehler, Axel, Vouros, Paul
Published in Analytical chemistry (Washington) (01.07.2001)
Published in Analytical chemistry (Washington) (01.07.2001)
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Journal Article
Entrectinib, a TRK/ROS1 inhibitor with anti-CNS tumor activity: differentiation from other inhibitors in its class due to weak interaction with P-glycoprotein
Fischer, Holger, Ullah, Mohammed, de la Cruz, Cecile C, Hunsaker, Thomas, Senn, Claudia, Wirz, Thomas, Wagner, Björn, Draganov, Dragomir, Vazvaei, Faye, Donzelli, Massimiliano, Paehler, Axel, Merchant, Mark, Yu, Li
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
Published in Neuro-oncology (Charlottesville, Va.) (09.06.2020)
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Journal Article
Meeting report of the 3rd European Biotransformation Workshop
Walles, Markus, Pähler, Axel, Isin, Emre M., Ahlqvist, Marie M.
Published in Xenobiotica (01.02.2023)
Published in Xenobiotica (01.02.2023)
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Journal Article
How Semiphysiological Population Pharmacokinetic Modeling Incorporating Active Hepatic Uptake Supports Phase II Dose Selection of RO7049389, A Novel Anti–Hepatitis B Virus Drug
Cosson, Valérie, Feng, Sheng, Jaminion, Felix, Lemenuel‐Diot, Annabelle, Parrott, Neil, Paehler, Axel, Bo, Qingyan, Jin, Yuyan
Published in Clinical pharmacology and therapeutics (01.04.2021)
Published in Clinical pharmacology and therapeutics (01.04.2021)
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Journal Article
Evaluation of the drug disposition of RO7049389 with in vitro data and human mass balance supported by physiologically based pharmacokinetic modelling
Zhang, Yuchen, Umehara, Kenichi, Romeo, Andrea A, Singh, Nand, Cantrill, Carina, Savage, Mark, Chen, Ethan, Zhang, Wen, Parrot, Neil John, Paehler, Axel
Published in British journal of clinical pharmacology (01.10.2023)
Published in British journal of clinical pharmacology (01.10.2023)
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Journal Article
Translating pharmacology models effectively to predict therapeutic benefit
Dudal, Sherri, Bissantz, Caterina, Caruso, Antonello, David-Pierson, Pascale, Driessen, Wouter, Koller, Erich, Krippendorff, Ben-Fillippo, Lechmann, Martin, Olivares-Morales, Andrés, Paehler, Axel, Rynn, Caroline, Türck, Dietrich, Van De Vyver, Arthur, Wang, Ken, Winther, Lotte
Published in Drug discovery today (01.06.2022)
Published in Drug discovery today (01.06.2022)
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Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MSE data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates
Brink, Andreas, Fontaine, Fabien, Marschmann, Michaela, Steinhuber, Bernd, Cece, Esra Nurten, Zamora, Ismael, Pähler, Axel
Published in Rapid communications in mass spectrometry (30.12.2014)
Published in Rapid communications in mass spectrometry (30.12.2014)
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Journal Article
In Vivo Biotransformation of the Fusion Protein Tetranectin-Apolipoprotein A1 Analyzed by Ligand-Binding Mass Spectrometry Combined with Quantitation by ELISA
Zell, Manfred, Husser, Christophe, Staack, Roland F, Jordan, Gregor, Richter, Wolfgang F, Schadt, Simone, Pähler, Axel
Published in Analytical chemistry (Washington) (06.12.2016)
Published in Analytical chemistry (Washington) (06.12.2016)
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Journal Article
Application of lipid peroxidation products as biomarkers for flutamide-induced oxidative stress in vitro
Teppner, Marieke, Böss, Franziska, Ernst, Beat, Pähler, Axel
Published in Toxicology letters (04.11.2015)
Published in Toxicology letters (04.11.2015)
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Journal Article
Quantitative profiling of prostaglandins as oxidative stress biomarkers in vitro and in vivo by negative ion online solid phase extraction – Liquid chromatography–tandem mass spectrometry
Teppner, Marieke, Zell, Manfred, Husser, Christophe, Ernst, Beat, Pähler, Axel
Published in Analytical biochemistry (01.04.2016)
Published in Analytical biochemistry (01.04.2016)
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Journal Article
Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression
Lindemann, Lothar, Porter, Richard H, Scharf, Sebastian H, Kuennecke, Basil, Bruns, Andreas, von Kienlin, Markus, Harrison, Anthony C, Paehler, Axel, Funk, Christoph, Gloge, Andreas, Schneider, Manfred, Parrott, Neil J, Polonchuk, Liudmila, Niederhauser, Urs, Morairty, Stephen R, Kilduff, Thomas S, Vieira, Eric, Kolczewski, Sabine, Wichmann, Juergen, Hartung, Thomas, Honer, Michael, Borroni, Edilio, Moreau, Jean-Luc, Prinssen, Eric, Spooren, Will, Wettstein, Joseph G, Jaeschke, Georg
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
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Journal Article
Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyllpyridine (Basimglurant, R04917523), a Promising Novel Medicine for Psychiatric Diseases
Jaeschke, Georg, Kolczewski, Sabine, Spooren, Will, Vieira, Eric, Bitter-Stoll, Nadia, Boissin, Patrick, Borroni, Edilio, Buettelmann, Bernd, Ceccarelli, Simona, Clemann, Nicole, David, Beatrice, Funk, Christoph, Guba, Wolfgang, Harrison, Anthony, Hartung, Thomas, Honer, Michael, Huwyler, Joerg, Kuratli, Martin, Niederhauser, Urs, Paehler, Axel, Peters, Jens-Uwe, Petersen, Ann, Prinssen, Eric, Ricci, Antonio, Rueher, Daniel, Rueher, Marianne, Schneider, Manfred, Spurr, Paul, Stoll, Theodor, Taennler, Daniel, Wichmann, Juergen, Porter, Richard H., Wettstein, Joseph G., Lindemann, Lothar
Published in Journal of medicinal chemistry (12.02.2015)
Published in Journal of medicinal chemistry (12.02.2015)
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Journal Article
Biomarkers of Flutamide-Bioactivation and Oxidative Stress In Vitro and In Vivo
Teppner, Marieke, Boess, Franziska, Ernst, Beat, Pähler, Axel
Published in Drug metabolism and disposition (01.04.2016)
Published in Drug metabolism and disposition (01.04.2016)
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Journal Article
Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor
Barrow, Paul, Parrott, Neil, Alberati, Daniela, Paehler, Axel, Koerner, Annette
Published in Birth defects research. Part B. Developmental and reproductive toxicology (01.06.2016)
Published in Birth defects research. Part B. Developmental and reproductive toxicology (01.06.2016)
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Journal Article
Software-aided cytochrome P450 reaction phenotyping and kinetic analysis in early drug discovery
Cece-Esencan, Esra Nurten, Fontaine, Fabien, Plasencia, Guillem, Teppner, Marieke, Brink, Andreas, Pähler, Axel, Zamora, Ismael
Published in Rapid communications in mass spectrometry (30.01.2016)
Published in Rapid communications in mass spectrometry (30.01.2016)
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Journal Article
BET Inhibition Enhances TNF-Mediated Antitumor Immunity
Wellinger, Lisa C, Hogg, Simon J, Newman, Dane M, Friess, Thomas, Geiss, Daniela, Michie, Jessica, Ramsbottom, Kelly M, Bacac, Marina, Fauti, Tanja, Marbach, Daniel, Jarassier, Laura, Thienger, Phillip, Paehler, Axel, Cluse, Leonie A, Kearney, Conor J, Vervoort, Stephin J, Trapani, Joseph A, Oliaro, Jane, Shortt, Jake, Ruefli-Brasse, Astrid, Rohle, Daniel, Johnstone, Ricky W
Published in Cancer immunology research (01.01.2022)
Published in Cancer immunology research (01.01.2022)
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Post-acquisition analysis of untargeted accurate mass quadrupole time-of-flight MS super(E) data for multiple collision-induced neutral losses and fragment ions of glutathione conjugates
Brink, Andreas, Fontaine, Fabien, Marschmann, Michaela, Steinhuber, Bernd, Cece, Esra Nurten, Zamora, Ismael, Paehler, Axel
Published in Rapid communications in mass spectrometry (01.12.2014)
Published in Rapid communications in mass spectrometry (01.12.2014)
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