PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma
Muz, Barbara, Buggio, Maurizio, Azab, Feda, de la Puente, Pilar, Fiala, Mark, Padval, Mahesh V, Weaver, David T, Pachter, Jonathan A, Vij, Ravi, Azab, Abdel Kareem
Published in Haematologica (Roma) (01.07.2019)
Published in Haematologica (Roma) (01.07.2019)
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Journal Article
Biotransformation and in vitro assessment of metabolism-associated drug–drug interaction for CRx-102, a novel combination drug candidate
Zhang, Zhi-Yi, Chen, Mei, Chen, Jennifer, Padval, Mahesh V., Kansra, Vikram V.
Published in Journal of pharmaceutical and biomedical analysis (08.09.2009)
Published in Journal of pharmaceutical and biomedical analysis (08.09.2009)
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Journal Article
PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells
Kolev, Vihren N, Wright, Quentin G, Vidal, Christian M, Ring, Jennifer E, Shapiro, Irina M, Ricono, Jill, Weaver, David T, Padval, Mahesh V, Pachter, Jonathan A, Xu, Qunli
Published in Cancer research (Chicago, Ill.) (15.01.2015)
Published in Cancer research (Chicago, Ill.) (15.01.2015)
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Journal Article
Development and validation of a liquid chromatography–tandem mass spectrometry assay for the simultaneous quantitation of prednisolone and dipyridamole in human plasma and its application in a pharmacokinetic study
Chen, Mei, Granvil, Camille, Ji, Qin C., Zhang, Zhi-Yi, Padval, Mahesh V., Kansra, Vikram V.
Published in Journal of pharmaceutical and biomedical analysis (12.07.2009)
Published in Journal of pharmaceutical and biomedical analysis (12.07.2009)
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Journal Article
SOLID DISPERSION FORMULATIONS AND METHODS OF USE THEREOF
CREW MARSHALL D, SMITHEY DANIEL T, HARIANAWALA ABIZER, PADVAL MAHESH V, GAUTSCHI JEFF T
Year of Publication 28.01.2014
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Year of Publication 28.01.2014
Patent
Abstract 213: VS-5584 a dual mTORC1/2 and PI3K inhibitor has anti-tumor activity in multiple in vivo xenograft tumor models and enhanced efficacy in combination with cisplatin or docetaxel
Trombino, Anthony F., Kolev, Vihren N., Wright, Quentin G., Xu, Qunli, Padval, Mahesh V.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract A36: Combined inhibition of PI3K isoforms and mTOR kinase is critical for cancer stem cell inhibition by VS-5584
Kolev, Vihren N., Wright, Quentin G., Weaver, David T., Padval, Mahesh V., Pachter, Jonathan A., Xu, Qunli
Published in Molecular cancer therapeutics (01.07.2015)
Published in Molecular cancer therapeutics (01.07.2015)
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Journal Article
Abstract 4797: VS-6063 (defactinib) targets cancer stem cells directly and through inhibition of tumor-associated macrophages and cytokine production
Pachter, Jonathan A., Ring, Jennifer E., Kolev, Vihren N., Shapiro, Irina M., Vidal, Christian M., Padval, Mahesh V., Xu, Qunli
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 3908: Focal adhesion kinase (FAK) inhibitor VS-6063 (defactinib) preferentially targets cancer stem cells in triple negative breast cancer
Xu, Qunli, Kolev, Vihren N., Wright, Quentin G., Ring, Jennifer E., Vidal, Christian M., Shapiro, Irina M., Weaver, David T., Padval, Mahesh V., Pachter, Jonathan A.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Abstract 239: The dual PI3K/mTOR inhibitor VS-5584 preferentially targets cancer stem cells in vitro and in vivo
Xu, Qunli, Kolev, Vihren N., Wright, Quentin G., Weaver, David T., Padval, Mahesh V., Pachter, Jonathan A.
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Journal Article
Abstract B283: Defactinib (VS-6063) targets cancer stem cells directly and through inhibition of tumor-associated macrophages and cytokine production
Ring, Jennifer E., Kolev, Vihren N., Shapiro, Irina M., Wright, Quentin G., Testa, Joseph R., Padval, Mahesh V., Xu, Qunli, Pachter, Jonathan A.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article
Abstract C271: FAK inhibitor defactinib (VS-6063) enhances the efficacy of paclitaxel and preferentially targets ovarian cancer stem cells
Vidal, Christian M., Kolev, Vihren N., Wright, Quentin G., Tam, Winnie F., Weaver, David T., Padval, Mahesh V., Xu, Qunli, Pachter, Jonathan A.
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Journal Article