Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, Hong, Hegde, Samarth, Knolhoff, Brett L, Zhu, Yu, Herndon, John M, Meyer, Melissa A, Nywening, Timothy M, Hawkins, William G, Shapiro, Irina M, Weaver, David T, Pachter, Jonathan A, Wang-Gillam, Andrea, DeNardo, David G
Published in Nature medicine (01.08.2016)
Published in Nature medicine (01.08.2016)
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Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity
Serrels, Alan, Lund, Tom, Serrels, Bryan, Byron, Adam, McPherson, Rhoanne C., von Kriegsheim, Alexander, Gómez-Cuadrado, Laura, Canel, Marta, Muir, Morwenna, Ring, Jennifer E., Maniati, Eleni, Sims, Andrew H., Pachter, Jonathan A., Brunton, Valerie G., Gilbert, Nick, Anderton, Stephen M., Nibbs, Robert J.B., Frame, Margaret C.
Published in Cell (24.09.2015)
Published in Cell (24.09.2015)
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The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma
Begum, Asma, Ewachiw, Theodore, Jung, Clinton, Huang, Ally, Norberg, K Jessica, Marchionni, Luigi, McMillan, Ross, Penchev, Vesselin, Rajeshkumar, N V, Maitra, Anirban, Wood, Laura, Wang, Chenguang, Wolfgang, Christopher, DeJesus-Acosta, Ana, Laheru, Daniel, Shapiro, Irina M, Padval, Mahesh, Pachter, Jonathan A, Weaver, David T, Rasheed, Zeshaan A, Matsui, William
Published in PloS one (10.07.2017)
Published in PloS one (10.07.2017)
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Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship
Shapiro, Irina M, Kolev, Vihren N, Vidal, Christian M, Kadariya, Yuwaraj, Ring, Jennifer E, Wright, Quentin, Weaver, David T, Menges, Craig, Padval, Mahesh, McClatchey, Andrea I, Xu, Qunli, Testa, Joseph R, Pachter, Jonathan A
Published in Science translational medicine (21.05.2014)
Published in Science translational medicine (21.05.2014)
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ROCK1 and ROCK2 Are Required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion
VIGIL, Dominico, TAI YOUNG KIM, DER, Channing J, PLACHCO, Ana, GARTON, Andrew J, CASTALDO, Linda, PACHTER, Jonathan A, HANQINGDONG, XIN CHEN, TOKAR, Brianna, CAMPBELL, Sharon L
Published in Cancer research (Chicago, Ill.) (15.10.2012)
Published in Cancer research (Chicago, Ill.) (15.10.2012)
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Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
Till, Kathleen J., Abdullah, Mariah, Alnassfan, Tahera, Janet, Gallardo Zapata, Marks, Thomas, Coma, Silvia, Weaver, David T., Pachter, Jonathan A., Pettitt, Andrew R., Slupsky, Joseph R.
Published in Scientific reports (07.03.2023)
Published in Scientific reports (07.03.2023)
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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer
Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R
Published in Molecular cancer therapeutics (01.10.2010)
Published in Molecular cancer therapeutics (01.10.2010)
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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin
Bhagwat, Shripad V, Gokhale, Prafulla C, Crew, Andrew P, Cooke, Andy, Yao, Yan, Mantis, Christine, Kahler, Jennifer, Workman, Jennifer, Bittner, Mark, Dudkin, Lorina, Epstein, David M, Gibson, Neil W, Wild, Robert, Arnold, Lee D, Houghton, Peter J, Pachter, Jonathan A
Published in Molecular cancer therapeutics (01.08.2011)
Published in Molecular cancer therapeutics (01.08.2011)
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In vivo activity of the dual PI3Kδ and PI3Kγ inhibitor duvelisib against pediatric acute lymphoblastic leukemia xenografts
Randall, Joanna, Evans, Kathryn, Watts, Ben, Smith, Christopher M., Hughes, Keira, Earley, Eric J., Erickson, Stephen W., Pachter, Jonathan A., Teicher, Beverly A., Smith, Malcolm A., Lock, Richard B.
Published in Pediatric blood & cancer (01.08.2023)
Published in Pediatric blood & cancer (01.08.2023)
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PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma
Muz, Barbara, Buggio, Maurizio, Azab, Feda, de la Puente, Pilar, Fiala, Mark, Padval, Mahesh V, Weaver, David T, Pachter, Jonathan A, Vij, Ravi, Azab, Abdel Kareem
Published in Haematologica (Roma) (01.07.2019)
Published in Haematologica (Roma) (01.07.2019)
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MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection
Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Geun Lee, Chun, A Elias, Jack, S Campbell, Kerry, T Naik, Mandar, J Atwood, Walter, Youssef, Emile, A Pachter, Jonathan, Navaraj, Arunasalam, A Seyhan, Attila, Liang, Olin, El-Deiry, Wafik S
Published in Oncotarget (17.11.2020)
Published in Oncotarget (17.11.2020)
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A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor–dependent tumor growth in vivo
Ji, Qun-sheng, Mulvihill, Mark J, Rosenfeld-Franklin, Maryland, Cooke, Andrew, Feng, Lixin, Mak, Gilda, O'Connor, Matthew, Yao, Yan, Pirritt, Caroline, Buck, Elizabeth, Eyzaguirre, Alexandra, Arnold, Lee D, Gibson, Neil W, Pachter, Jonathan A
Published in Molecular cancer therapeutics (01.08.2007)
Published in Molecular cancer therapeutics (01.08.2007)
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Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti–IGF-IR antibody
Wang, Yan, Hailey, Judith, Williams, Denise, Wang, Yaolin, Lipari, Philip, Malkowski, Michael, Wang, Xiaoying, Xie, Lei, Li, Guanghua, Saha, Deba, Ling, Wai Lam W, Cannon-Carlson, Susan, Greenberg, Robert, Ramos, Robert A, Shields, Robert, Presta, Leonard, Brams, Peter, Bishop, W Robert, Pachter, Jonathan A
Published in Molecular cancer therapeutics (01.08.2005)
Published in Molecular cancer therapeutics (01.08.2005)
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A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK
Feng, Xiaodong, Arang, Nadia, Rigiracciolo, Damiano Cosimo, Lee, Joo Sang, Yeerna, Huwate, Wang, Zhiyong, Lubrano, Simone, Kishore, Ayush, Pachter, Jonathan A., König, Gabriele M., Maggiolini, Marcello, Kostenis, Evi, Schlaepfer, David D., Tamayo, Pablo, Chen, Qianming, Ruppin, Eytan, Gutkind, J. Silvio
Published in Cancer cell (18.03.2019)
Published in Cancer cell (18.03.2019)
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Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
Jiang, Hong, Liu, Xiuting, Knolhoff, Brett L, Hegde, Samarth, Lee, Kyung Bae, Jiang, Hongmei, Fields, Ryan C, Pachter, Jonathan A, Lim, Kian-Huat, DeNardo, David G
Published in Gut (01.01.2020)
Published in Gut (01.01.2020)
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PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity
Funk, Christopher Ronald, Wang, Shuhua, Chen, Kevin Z., Waller, Alexandra, Sharma, Aditi, Edgar, Claudia L., Gupta, Vikas A., Chandrakasan, Shanmuganathan, Zoine, Jaquelyn T., Fedanov, Andrew, Raikar, Sunil S., Koff, Jean L., Flowers, Christopher R., Coma, Silvia, Pachter, Jonathan A., Ravindranathan, Sruthi, Spencer, H. Trent, Shanmugam, Mala, Waller, Edmund K.
Published in Blood (27.01.2022)
Published in Blood (27.01.2022)
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Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study
Fennell, Dean A, Baas, Paul, Taylor, Paul, Nowak, Anna K, Gilligan, David, Nakano, Takashi, Pachter, Jonathan A, Weaver, David T, Scherpereel, Arnaud, Pavlakis, Nick, van Meerbeeck, Jan P, Cedrés, Susana, Nolan, Luke, Kindler, Hedy, Aerts, Joachim G J V
Published in Journal of clinical oncology (01.04.2019)
Published in Journal of clinical oncology (01.04.2019)
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Synthetic Lethal Screens Reveal Cotargeting FAK and MEK as a Multimodal Precision Therapy for GNAQ -Driven Uveal Melanoma
Paradis, Justine S, Acosta, Monica, Saddawi-Konefka, Robert, Kishore, Ayush, Gomes, Frederico, Arang, Nadia, Tiago, Manoela, Coma, Silvia, Lubrano, Simone, Wu, Xingyu, Ford, Kyle, Day, Chi-Ping, Merlino, Glenn, Mali, Prashant, Pachter, Jonathan A, Sato, Takami, Aplin, Andrew E, Gutkind, J Silvio
Published in Clinical cancer research (01.06.2021)
Published in Clinical cancer research (01.06.2021)
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Dual Stromal Targeting Sensitizes Pancreatic Adenocarcinoma for Anti-Programmed Cell Death Protein 1 Therapy
Blair, Alex B., Wang, Jianxin, Davelaar, John, Baker, Andrew, Li, Keyu, Niu, Nan, Wang, Junke, Shao, Yingkuan, Funes, Vanessa, Li, Pan, Pachter, Jonathan A., Maneval, Daniel C., Dezem, Felipe, Plummer, Jasmine, Chan, Keith Syson, Gong, Jun, Hendifar, Andrew E., Pandol, Stephen J., Burkhart, Richard, Zhang, Yuqing, Zheng, Lei, Osipov, Arsen
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2022)
Published in Gastroenterology (New York, N.Y. 1943) (01.11.2022)
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Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models
Iannello, Andrea, Vitale, Nicoletta, Coma, Silvia, Arruga, Francesca, Chadburn, Amy, Di Napoli, Arianna, Laudanna, Carlo, Allan, John N., Furman, Richard R., Pachter, Jonathan A., Deaglio, Silvia, Vaisitti, Tiziana
Published in Blood (17.06.2021)
Published in Blood (17.06.2021)
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