Phosphorylation of cytosolic hPGK1 affects protein stability and ligand binding: implications for its subcellular targeting in cancer
Pacheco‐García, Juan Luis, Cano‐Muñoz, Mario, Loginov, Dmitry S., Vankova, Pavla, Man, Petr, Pey, Angel L.
Published in The FEBS journal (01.11.2024)
Published in The FEBS journal (01.11.2024)
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Journal Article
Counterintuitive structural and functional effects due to naturally occurring mutations targeting the active site of the disease‐associated NQO1 enzyme
Pacheco‐García, Juan Luis, Anoz‐Carbonell, Ernesto, Loginov, Dmitry S., Kavan, Daniel, Salido, Eduardo, Man, Petr, Medina, Milagros, Pey, Angel L.
Published in The FEBS journal (01.04.2023)
Published in The FEBS journal (01.04.2023)
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Journal Article
Structural dynamics at the active site of the cancer‐associated flavoenzyme NQO1 probed by chemical modification with PMSF
Grieco, Alice, Ruiz‐Fresneda, Miguel A., Gómez‐Mulas, Atanasio, Pacheco‐García, Juan Luis, Quereda‐Moraleda, Isabel, Pey, Angel L., Martin‐Garcia, Jose M.
Published in FEBS letters (01.11.2023)
Published in FEBS letters (01.11.2023)
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Journal Article
Loss of stability and unfolding cooperativity in hPGK1 upon gradual structural perturbation of its N-terminal domain hydrophobic core
Pacheco-García, Juan Luis, Loginov, Dmitry S., Naganathan, Athi N., Vankova, Pavla, Cano-Muñoz, Mario, Man, Petr, Pey, Angel L.
Published in Scientific reports (13.10.2022)
Published in Scientific reports (13.10.2022)
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Journal Article
A single evolutionarily divergent mutation determines the different FAD‐binding affinities of human and rat NQO1 due to site‐specific phosphorylation
Pacheco‐Garcia, Juan Luis, Loginov, Dmitry, Rizzuti, Bruno, Vankova, Pavla, Neira, Jose L., Kavan, Daniel, Mesa‐Torres, Noel, Guzzi, Rita, Man, Petr, Pey, Angel L.
Published in FEBS letters (01.01.2022)
Published in FEBS letters (01.01.2022)
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Journal Article
Structural basis of the pleiotropic and specific phenotypic consequences of missense mutations in the multifunctional NAD(P)H:quinone oxidoreductase 1 and their pharmacological rescue
Pacheco-Garcia, Juan Luis, Anoz-Carbonell, Ernesto, Vankova, Pavla, Kannan, Adithi, Palomino-Morales, Rogelio, Mesa-Torres, Noel, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Published in Redox biology (01.10.2021)
Published in Redox biology (01.10.2021)
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Journal Article
Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations
Pacheco-Garcia, Juan Luis, Loginov, Dmitry S., Anoz-Carbonell, Ernesto, Vankova, Pavla, Palomino-Morales, Rogelio, Salido, Eduardo, Man, Petr, Medina, Milagros, Naganathan, Athi N., Pey, Angel L.
Published in Antioxidants (02.06.2022)
Published in Antioxidants (02.06.2022)
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Journal Article
Insights into the pathogenesis of primary hyperoxaluria type I from the structural dynamics of alanine:glyoxylate aminotransferase variants
Vankova, Pavla, Pacheco‐Garcia, Juan Luis, Loginov, Dmitry S., Gómez‐Mulas, Atanasio, Kádek, Alan, Martín‐Garcia, José Manuel, Salido, Eduardo, Man, Petr, Pey, Angel L.
Published in FEBS letters (01.02.2024)
Published in FEBS letters (01.02.2024)
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Journal Article
Phosphorylation compromises FAD binding and intracellular stability of wild-type and cancer-associated NQO1: Insights into flavo-proteome stability
Medina-Carmona, Encarnación, Rizzuti, Bruno, Martín-Escolano, Rubén, Pacheco-García, Juan Luis, Mesa-Torres, Noel, Neira, José L., Guzzi, Rita, Pey, Angel L.
Published in International journal of biological macromolecules (15.03.2019)
Published in International journal of biological macromolecules (15.03.2019)
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Journal Article
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: Comparison of experiments and computation
Pacheco-Garcia, Juan Luis, Cagiada, Matteo, Tienne-Matos, Kelly, Salido, Eduardo, Lindorff-Larsen, Kresten, L Pey, Angel
Published in Frontiers in molecular biosciences (24.11.2022)
Published in Frontiers in molecular biosciences (24.11.2022)
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Journal Article
Naturally-Occurring Rare Mutations Cause Mild to Catastrophic Effects in the Multifunctional and Cancer-Associated NQO1 Protein
Pacheco-García, Juan Luis, Cano-Muñoz, Mario, Sánchez-Ramos, Isabel, Salido, Eduardo, Pey, Angel L
Published in Journal of personalized medicine (03.11.2020)
Published in Journal of personalized medicine (03.11.2020)
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Journal Article
Different phenotypic outcome due to site-specific phosphorylation in the cancer-associated NQO1 enzyme studied by phosphomimetic mutations
Pacheco-Garcia, Juan Luis, Anoz-Carbonell, Ernesto, Loginov, Dmitry S., Vankova, Pavla, Salido, Eduardo, Man, Petr, Medina, Milagros, Palomino-Morales, Rogelio, Pey, Angel L.
Published in Archives of biochemistry and biophysics (30.10.2022)
Published in Archives of biochemistry and biophysics (30.10.2022)
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Journal Article
Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme
Doppler, Diandra, Sonker, Mukul, Egatz-Gomez, Ana, Grieco, Alice, Zaare, Sahba, Jernigan, Rebecca, Meza-Aguilar, Jose Domingo, Rabbani, Mohammad T, Manna, Abhik, Alvarez, Roberto C, Karpos, Konstantinos, Cruz Villarreal, Jorvani, Nelson, Garrett, Yang, Jay-How, Carrion, Jackson, Morin, Katherine, Ketawala, Gihan K, Pey, Angel L, Ruiz-Fresneda, Miguel Angel, Pacheco-Garcia, Juan Luis, Hermoso, Juan A, Nazari, Reza, Sierra, Raymond, Hunter, Mark S, Batyuk, Alexander, Kupitz, Christopher J, Sublett, Robert E, Lisova, Stella, Mariani, Valerio, Boutet, Sébastien, Fromme, Raimund, Grant, Thomas D, Botha, Sabine, Fromme, Petra, Kirian, Richard A, Martin-Garcia, Jose Manuel, Ros, Alexandra
Published in Lab on a chip (28.06.2023)
Published in Lab on a chip (28.06.2023)
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Journal Article
Modular droplet injector for sample conservation providing new structural insight for the conformational heterogeneity in the disease-associated NQO1 enzyme
Doppler, Diandra, Sonker, Mukul, Egatz-Gomez, Ana, Grieco, Alice, Zaare, Sahba, Jernigan, Rebecca, Meza-Aguilar, Jose Domingo, Rabbani, Mohammad T., Manna, Abhik, Alvarez, Roberto C., Karpos, Konstantinos, Cruz Villarreal, Jorvani, Nelson, Garrett, Yang, Jay-How, Carrion, Jackson, Morin, Katherine, Ketawala, Gihan K., Pey, Angel L., Ruiz-Fresneda, Miguel Angel, Pacheco-Garcia, Juan Luis, Hermoso, Juan A., Nazari, Reza, Sierra, Raymond, Hunter, Mark S., Batyuk, Alexander, Kupitz, Christopher J., Sublett, Robert E., Lisova, Stella, Mariani, Valerio, Boutet, Sébastien, Fromme, Raimund, Grant, Thomas D., Botha, Sabine, Fromme, Petra, Kirian, Richard A., Martin-Garcia, Jose Manuel, Ros, Alexandra
Published in Lab on a chip (01.01.2023)
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Published in Lab on a chip (01.01.2023)
Journal Article
Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1: Implications of Genetic Diversity of NQO1
Salido, Eduardo, Timson, David J, Betancor-Fernández, Isabel, Palomino-Morales, Rogelio, Anoz-Carbonell, Ernesto, Pacheco-García, Juan Luis, Medina, Milagros, Pey, Angel L
Published in Journal of personalized medicine (05.05.2022)
Published in Journal of personalized medicine (05.05.2022)
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Journal Article
Effect of naturally-occurring mutations on the stability and function of cancer-associated NQO1: comparison of experiments and computation
Pacheco-Garcia, Juan Luis, Cagiada, Matteo, Tienne-Matos, Kelly, Salido, Eduardo, Lindorff-Larsen, Kresten, Pey, Angel Luis
Published in bioRxiv (03.10.2022)
Published in bioRxiv (03.10.2022)
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