Synthesis of Hantzsch Adducts as Cholinesterases and Calcium Flux inhibitors, Antioxidants and Neuroprotectives
Pachón Angona, Irene, Martin, Helene, Daniel, Solene, Moraleda, Ignacio, Bonet, Alexandre, Wnorowski, Artur, Maj, Maciej, Jozwiak, Krzysztof, Iriepa, Isabel, Refouvelet, Bernard, Marco-Contelles, José, Ismaili, Lhassane
Published in International journal of molecular sciences (16.10.2020)
Published in International journal of molecular sciences (16.10.2020)
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Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
Pachón-Angona, Irene, Bernard, Paul J., Simakov, Alexey, Maj, Maciej, Jozwiak, Krzysztof, Novotna, Anna, Lemke, Carina, Gütschow, Michael, Martin, Helene, Oset-Gasque, María-Jesús, Contelles, José-Marco, Ismaili, Lhassane
Published in Pharmaceutics (17.01.2024)
Published in Pharmaceutics (17.01.2024)
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Journal Article
Synthesis of new Hantzsch adducts showing Ca2+ channel blockade capacity, cholinesterase inhibition and antioxidant power
Pachón-Angona, Irene, Maj, Maciej, Wnorowski, Artur, Martin, Helene, Jóźwiak, Krzysztof, Ismaili, Lhassane
Published in Future medicinal chemistry (01.10.2021)
Published in Future medicinal chemistry (01.10.2021)
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Journal Article
Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy
Pachón-Angona, Irene, Refouvelet, Bernard, Andrýs, Rudolf, Martin, Helène, Luzet, Vincent, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Oset-Gasque, María-Jesús, Marco-Contelles, José, Musilek, Kamil, Ismaili, Lhassane
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
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Journal Article
Design, Synthesis and Biological Evaluation of New Antioxidant and Neuroprotective Multitarget Directed Ligands Able to Block Calcium Channels
Pachòn Angona, Irene, Daniel, Solene, Martin, Helene, Bonet, Alexandre, Wnorowski, Artur, Maj, Maciej, Jóźwiak, Krzysztof, Silva, Tiago Barros, Refouvelet, Bernard, Borges, Fernanda, Marco-Contelles, José, Ismaili, Lhassane
Published in Molecules (Basel, Switzerland) (14.03.2020)
Published in Molecules (Basel, Switzerland) (14.03.2020)
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Journal Article
Ferulic acid derivatives block coronaviruses HCoV-229E and SARS-CoV-2 replication in vitro
Pasquereau, Sébastien, Galais, Mathilde, Bellefroid, Maxime, Pachón Angona, Irene, Morot-Bizot, Stéphanie, Ismaili, Lhassane, Van Lint, Carine, Herbein, Georges
Published in Scientific reports (24.11.2022)
Published in Scientific reports (24.11.2022)
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Synthesis, antioxidant and Aβ anti-aggregation properties of new ferulic, caffeic and lipoic acid derivatives obtained by the Ugi four-component reaction
Benchekroun, Mohamed, Pachón-Angona, Irene, Luzet, Vincent, Martin, Helene, Oset-Gasque, María-Jesús, Marco-Contelles, José, Ismaili, Lhassane
Published in Bioorganic chemistry (01.04.2019)
Published in Bioorganic chemistry (01.04.2019)
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Journal Article
Synthesis of new ferulic/lipoic/comenic acid-melatonin hybrids as antioxidants and Nrf2 activators via Ugi reaction
Pachón-Angona, Irene, Martin, Helène, Chhor, Stecy, Oset-Gasque, María-Jesús, Refouvelet, Bernard, Marco-Contelles, José, Ismaili, Lhassane
Published in Future medicinal chemistry (01.12.2019)
Published in Future medicinal chemistry (01.12.2019)
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Journal Article
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy
Zribi, Lazhar, Pachòn-Angona, Irene, Bautista-Aguilera, Òscar M, Diez-Iriepa, Daniel, Marco-Contelles, José, Ismaili, Lhassane, Iriepa, Isabel, Chabchoub, Fakher
Published in Molecules (Basel, Switzerland) (13.07.2020)
Published in Molecules (Basel, Switzerland) (13.07.2020)
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Leveraging molecular structure and bioactivity with chemical language models for de novo drug design
Moret, Michael, Pachon Angona, Irene, Cotos, Leandro, Yan, Shen, Atz, Kenneth, Brunner, Cyrill, Baumgartner, Martin, Grisoni, Francesca, Schneider, Gisbert
Published in Nature communications (07.01.2023)
Published in Nature communications (07.01.2023)
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Journal Article
Synthesis of new Hantzsch adducts showing Ca 2+ channel blockade capacity, cholinesterase inhibition and antioxidant power
Pachón-Angona, Irene, Maj, Maciej, Wnorowski, Artur, Martin, Helene, Jóźwiak, Krzysztof, Ismaili, Lhassane
Published in Future medicinal chemistry (01.10.2021)
Published in Future medicinal chemistry (01.10.2021)
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Journal Article
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca 2+ Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
Pachón-Angona, Irene, Bernard, Paul J, Simakov, Alexey, Maj, Maciej, Jozwiak, Krzysztof, Novotna, Anna, Lemke, Carina, Gütschow, Michael, Martin, Helene, Oset-Gasque, María-Jesús, Contelles, José-Marco, Ismaili, Lhassane
Published in Pharmaceutics (17.01.2024)
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Published in Pharmaceutics (17.01.2024)
Journal Article
Design and Synthesis of Multi-Functional Ligands through Hantzsch Reaction: Targeting Ca[sup.2+] Channels, Activating Nrf2 and Possessing Cathepsin S Inhibitory, and Antioxidant Properties
Pachón-Angona, Irene, Bernard, Paul J, Simakov, Alexey, Maj, Maciej, Jozwiak, Krzysztof, Novotna, Anna, Lemke, Carina, Gütschow, Michael, Ma, Oset-Gasque, María-Jesús, Contelles, José-Marco, Ismaili, Lhassane
Published in Pharmaceutics (01.01.2024)
Published in Pharmaceutics (01.01.2024)
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Journal Article
Donepezil plus chromone plus melatonin hybrids as promising agents for Alzheimer's disease therapy
Pachon-Angona, Irene, Refouvelet, Bernard, Andrys, Rudolf, Martin, Helene, Luzet, Vincent, Iriepa, Isabel, Moraleda, Ignacio, Diez-Iriepa, Daniel, Oset-Gasque, Maria-Jesus, Marco-Contelles, Jose, Musilek, Kamil, Ismaili, Lhassane
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2019)
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Journal Article