G10 is a direct activator of human STING
Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C, Yadav, Dharmendra B, Surya, Arjun
Published in PloS one (10.09.2020)
Published in PloS one (10.09.2020)
Get full text
Journal Article
The discovery of potent small molecule cyclic urea activators of STING
Basu, Sourav, Middya, Sandip, Banerjee, Monali, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Shrivastava, Ritesh, Surya, Arjun
Published in European journal of medicinal chemistry (05.02.2022)
Published in European journal of medicinal chemistry (05.02.2022)
Get full text
Journal Article
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
Bagnéris, Claire, DeCaen, Paul G., Naylor, Claire E., Pryde, David C., Nobeli, Irene, Clapham, David E., Wallace, B. A.
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2014)
Get full text
Journal Article
The discovery of potent small molecule activators of human STING
Pryde, David C., Middya, Sandip, Banerjee, Monali, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Yadav, Dharmendra B., Surya, Arjun
Published in European journal of medicinal chemistry (01.01.2021)
Published in European journal of medicinal chemistry (01.01.2021)
Get full text
Journal Article
A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels
Schewe, Marcus, Sun, Han, Mert, Ümit, Mackenzie, Alexandra, Pike, Ashley C W, Schulz, Friederike, Constantin, Cristina, Vowinkel, Kirsty S, Conrad, Linus J, Kiper, Aytug K, Gonzalez, Wendy, Musinszki, Marianne, Tegtmeier, Marie, Pryde, David C, Belabed, Hassane, Nazare, Marc, de Groot, Bert L, Decher, Niels, Fakler, Bernd, Carpenter, Elisabeth P, Tucker, Stephen J, Baukrowitz, Thomas
Published in Science (American Association for the Advancement of Science) (22.02.2019)
Published in Science (American Association for the Advancement of Science) (22.02.2019)
Get full text
Journal Article
Valproic acid interactions with the NavMs voltage-gated sodium channel
Zanatta, Geancarlo, Sula, Altin, Miles, Andrew J., Ng, Leo C. T., Torella, Rubben, Pryde, David C., DeCaen, Paul G., Wallace, B. A.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
Get full text
Journal Article
Ion Channels as Therapeutic Targets: A Drug Discovery Perspective
Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
Get full text
Journal Article
Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice
Pryde, David C, Jones, Lyn H, Gervais, David P, Stead, David R, Blakemore, David C, Selby, Matthew D, Brown, Alan D, Coe, Jotham W, Badland, Matthew, Beal, David M, Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J, White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R, Davis, Heather L, McCluskie, Michael J
Published in PloS one (01.10.2013)
Published in PloS one (01.10.2013)
Get full text
Journal Article
Exploring the Dynamics of the TWIK-1 Channel
Oakes, Victoria, Furini, Simone, Pryde, David, Domene, Carmen
Published in Biophysical journal (23.08.2016)
Published in Biophysical journal (23.08.2016)
Get full text
Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)
Owen, Robert M, Blakemore, David, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A, Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C, Reynolds, David S, Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
Get full text
Journal Article
A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction
Rooney, Timothy P. C., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A., Hay, Duncan A., Martin, Sarah, Tumber, Anthony, Rogers, Catherine M., Philpott, Martin, Wang, Minghua, Thompson, Amber L., Heightman, Tom D., Pryde, David C., Cook, Andrew, Paton, Robert S., Müller, Susanne, Knapp, Stefan, Brennan, Paul E., Conway, Stuart J.
Published in Angewandte Chemie International Edition (10.06.2014)
Published in Angewandte Chemie International Edition (10.06.2014)
Get full text
Journal Article
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Tseng, Wei Chou, Pryde, David C., Yoger, Katrina E., Padilla, Karen M., Antonio, Brett M., Han, Seungil, Shanmugasundaram, Veerabahu, Gerlach, Aaron C.
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
Get full text
Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABA(A) Positive Allosteric Modulator (PF-06372865)
Owen, Robert M., Blakemore, David, Cao, Lishuan, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R., Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A., Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C., Reynolds, David S., Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S., Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
Get full text
Journal Article
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes
Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.
Published in Structure (London) (03.04.2018)
Published in Structure (London) (03.04.2018)
Get full text
Journal Article
Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
Pryde, David C, Dalvie, Deepak, Hu, Qiyue, Jones, Peter, Obach, R. Scott, Tran, Thien-Duc
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
Get full text
Journal Article
Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action
TARGETT-ADAMS, Paul, GRAHAM, Emily J. S, STAMMEN, Blanda, PRYDE, David, PICKFORD, Chris, WESTBY, Mike, MIDDLETON, Jenny, PALMER, Amy, SHAW, Stephen M, LAVENDER, Helen, BRAIN, Philip, THIEN DUC TRAN, JONES, Lyn H, WAKENHUT, Florian
Published in Journal of Virology (01.07.2011)
Published in Journal of Virology (01.07.2011)
Get full text
Journal Article
Antiviral applications of Toll-like receptor agonists
Horscroft, Nigel J., Pryde, David C., Bright, Helen
Published in Journal of antimicrobial chemotherapy (01.04.2012)
Published in Journal of antimicrobial chemotherapy (01.04.2012)
Get full text
Journal Article
Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site
LAXTON, Carl, BRADY, Kevin, MOSCHOS, Sterghios, TURNPENNY, Paul, RAWAL, Jaiessh, PRYDE, David C, SIDDERS, Ben, CORBAU, Romu, PICKFORD, Chris, MURRAY, E. J
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Get full text
Journal Article