FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity
Wang, Xiaoxin X, Wang, Dong, Luo, Yuhuan, Myakala, Komuraiah, Dobrinskikh, Evgenia, Rosenberg, Avi Z, Levi, Jonathan, Kopp, Jeffrey B, Field, Amanda, Hill, Ashley, Lucia, Scott, Qiu, Liru, Jiang, Tao, Peng, Yingqiong, Orlicky, David, Garcia, Gabriel, Herman-Edelstein, Michal, D'Agati, Vivette, Henriksen, Kammi, Adorini, Luciano, Pruzanski, Mark, Xie, Cen, Krausz, Kristopher W, Gonzalez, Frank J, Ranjit, Suman, Dvornikov, Alexander, Gratton, Enrico, Levi, Moshe
Published in Journal of the American Society of Nephrology (01.01.2018)
Published in Journal of the American Society of Nephrology (01.01.2018)
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Journal Article
Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease
McMahan, Rachel H., Wang, Xiaoxin X., Cheng, Lin Ling, Krisko, Tibor, Smith, Maxwell, El Kasmi, Karim, Pruzanski, Mark, Adorini, Luciano, Golden-Mason, Lucy, Levi, Moshe, Rosen, Hugo R.
Published in The Journal of biological chemistry (26.04.2013)
Published in The Journal of biological chemistry (26.04.2013)
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Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist
Rizzo, Giovanni, Passeri, Daniela, De Franco, Francesca, Ciaccioli, Gianmario, Donadio, Loredana, Rizzo, Giorgia, Orlandi, Stefano, Sadeghpour, Bahman, Wang, Xiaoxin X, Jiang, Tao, Levi, Moshe, Pruzanski, Mark, Adorini, Luciano
Published in Molecular pharmacology (01.10.2010)
Published in Molecular pharmacology (01.10.2010)
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Journal Article
The farnesoid X receptor modulates renal lipid metabolism and diet-induced renal inflammation, fibrosis, and proteinuria
Wang, Xiaoxin X, Jiang, Tao, Shen, Yan, Adorini, Luciano, Pruzanski, Mark, Gonzalez, Frank J, Scherzer, Pnina, Lewis, Linda, Miyazaki-Anzai, Shinobu, Levi, Moshe
Published in American Journal of Physiology - Renal Physiology (01.12.2009)
Published in American Journal of Physiology - Renal Physiology (01.12.2009)
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Journal Article
Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
WANG, Xiaoxin X, TAO JIANG, GONZALEZ, Frank J, ADORINI, Luciano, PRUZANSKI, Mark, KOPP, Jeffrey B, VERLANDER, Jill W, LEVI, Moshe, YAN SHEN, CALDAS, Yupanqui, MIYAZAKI-ANZAI, Shinobu, SANTAMARIA, Hannah, URBANEK, Cydney, SOLIS, Nathaniel, SCHERZER, Pnina, LEWIS, Linda
Published in Diabetes (New York, N.Y.) (01.11.2010)
Published in Diabetes (New York, N.Y.) (01.11.2010)
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A Farnesoid X Receptor-Small Heterodimer Partner Regulatory Cascade Modulates Tissue Metalloproteinase Inhibitor-1 and Matrix Metalloprotease Expression in Hepatic Stellate Cells and Promotes Resolution of Liver Fibrosis
Fiorucci, Stefano, Rizzo, Giovanni, Antonelli, Elisabetta, Renga, Barbara, Mencarelli, Andrea, Riccardi, Luisa, Orlandi, Stefano, Pruzanski, Mark, Morelli, Antonio, Pellicciari, Roberto
Published in The Journal of pharmacology and experimental therapeutics (01.08.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2005)
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Journal Article
Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis
Fiorucci, Stefano, Clerici, Carlo, Antonelli, Elisabetta, Orlandi, Stefano, Goodwin, Bryan, Sadeghpour, Bahman M, Sabatino, Giuseppe, Russo, Giuseppe, Castellani, Danilo, Willson, Timothy M, Pruzanski, Mark, Pellicciari, Roberto, Morelli, Antonio
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2005)
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Journal Article
Avicholic Acid: A Lead Compound from Birds on the Route to Potent TGR5 Modulators
Pellicciari, Roberto, Gioiello, Antimo, Sabbatini, Paola, Venturoni, Francesco, Nuti, Roberto, Colliva, Carolina, Rizzo, Giovanni, Adorini, Luciano, Pruzanski, Mark, Roda, Aldo, Macchiarulo, Antonio
Published in ACS medicinal chemistry letters (12.04.2012)
Published in ACS medicinal chemistry letters (12.04.2012)
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Journal Article
Targeting bile-acid signalling for metabolic diseases
Auwerx, Johan, Schoonjans, Kristina, Thomas, Charles, Pellicciari, Roberto, Pruzanski, Mark
Published in Nature reviews. Drug discovery (01.08.2008)
Published in Nature reviews. Drug discovery (01.08.2008)
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Journal Article
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Thomas, Charles, Gioiello, Antimo, Noriega, Lilia, Strehle, Axelle, Oury, Julien, Rizzo, Giovanni, Macchiarulo, Antonio, Yamamoto, Hiroyasu, Mataki, Chikage, Pruzanski, Mark, Pellicciari, Roberto, Auwerx, Johan, Schoonjans, Kristina
Published in Cell metabolism (01.09.2009)
Published in Cell metabolism (01.09.2009)
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Journal Article
A dual agonist of farnesoid X receptor (FXR) and the G protein–coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice
Wang, Xiaoxin X., Luo, Yuhuan, Wang, Dong, Adorini, Luciano, Pruzanski, Mark, Dobrinskikh, Evgenia, Levi, Moshe
Published in The Journal of biological chemistry (21.07.2017)
Published in The Journal of biological chemistry (21.07.2017)
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A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis
Nevens, Frederik, Andreone, Pietro, Mazzella, Giuseppe, Strasser, Simone I, Bowlus, Christopher, Invernizzi, Pietro, Drenth, Joost P.H, Pockros, Paul J, Regula, Jaroslaw, Beuers, Ulrich, Trauner, Michael, Jones, David E, Floreani, Annarosa, Hohenester, Simon, Luketic, Velimir, Shiffman, Mitchell, van Erpecum, Karel J, Vargas, Victor, Vincent, Catherine, Hirschfield, Gideon M, Shah, Hemant, Hansen, Bettina, Lindor, Keith D, Marschall, Hanns-Ulrich, Kowdley, Kris V, Hooshmand-Rad, Roya, Marmon, Tonya, Sheeron, Shawn, Pencek, Richard, MacConell, Leigh, Pruzanski, Mark, Shapiro, David
Published in The New England journal of medicine (18.08.2016)
Published in The New England journal of medicine (18.08.2016)
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Journal Article
Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Mudaliar, Sunder, Henry, Robert R, Sanyal, Arun J, Morrow, Linda, Marschall, Hanns–Ulrich, Kipnes, Mark, Adorini, Luciano, Sciacca, Cathi I, Clopton, Paul, Castelloe, Erin, Dillon, Paul, Pruzanski, Mark, Shapiro, David
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.09.2013)
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370-OR: Optimized Weight Loss with Bimagrumab—Reduced Fat Mass with Increased Muscle Mass by Appetite-Independent Mechanisms
ATTIE, KENNETH M., HEYMSFIELD, STEVEN B., MINDEHOLM, LINDA, SPRUILL, SUSAN, PRUZANSKI, MARK, KLICKSTEIN, LLOYD
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
Pellicciari, Roberto, Gioiello, Antimo, Macchiarulo, Antonio, Thomas, Charles, Rosatelli, Emiliano, Natalini, Benedetto, Sardella, Roccaldo, Pruzanski, Mark, Roda, Aldo, Pastorini, Elisabetta, Schoonjans, Kristina, Auwerx, Johan
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists
Marinozzi, Maura, Carotti, Andrea, Sansone, Emanuele, Macchiarulo, Antonio, Rosatelli, Emiliano, Sardella, Roccaldo, Natalini, Benedetto, Rizzo, Giovanni, Adorini, Luciano, Passeri, Daniela, De Franco, Francesca, Pruzanski, Mark, Pellicciari, Roberto
Published in Bioorganic & medicinal chemistry (01.06.2012)
Published in Bioorganic & medicinal chemistry (01.06.2012)
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