Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors
Kashem, Mohammed A, Nelson, Richard M, Yingling, Jeffrey D, Pullen, Steven S, Prokopowicz, 3rd, Anthony S, Jones, Jessi Wildeson, Wolak, John P, Rogers, George R, Morelock, Maurice M, Snow, Roger J, Homon, Carol Ann, Jakes, Scott
Published in Journal of biomolecular screening (01.02.2007)
Published in Journal of biomolecular screening (01.02.2007)
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Journal Article
Discovery of potent and selective PKC-θ inhibitors
Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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Journal Article
Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats
GINN, John D, BOSANAC, Todd, SCHLYER, Sabine, SMITH, James D, TURNER, Michael R, WU, Frank, YOUNG, Erick R. R, CHEN, Rhonda, CYWIN, Charles, HICKEY, Eugene, KASHEM, Mohammed, KERR, Steven, KUGLER, Stanley, XIANG LI, PROKOPOWICZ, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Journal Article
Hit to Lead Account of the Discovery of a New Class of Inhibitors of Pim Kinases and Crystallographic Studies Revealing an Unusual Kinase Binding Mode
Qian, Kevin, Wang, Lian, Cywin, Charles L, Farmer, Bennett T, Hickey, Eugene, Homon, Carol, Jakes, Scott, Kashem, Mohammed A, Lee, George, Leonard, Scott, Li, Jun, Magboo, Ronald, Mao, Wang, Pack, Edward, Peng, Charlene, Prokopowicz, Anthony, Welzel, Morgan, Wolak, John, Morwick, Tina
Published in Journal of medicinal chemistry (09.04.2009)
Published in Journal of medicinal chemistry (09.04.2009)
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Journal Article
Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase
Snow, Roger J, Cardozo, Mario G, Morwick, Tina M, Busacca, Carl A, Dong, Yong, Eckner, Robert J, Jacober, Stephen, Jakes, Scott, Kapadia, Suresh, Lukas, Susan, Panzenbeck, Maret, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Sellati, Rosemarie, Tolbert, Robert M, Tschantz, Matt A, Moss, Neil
Published in Journal of medicinal chemistry (01.08.2002)
Published in Journal of medicinal chemistry (01.08.2002)
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Journal Article
Optimization of 2-Phenylaminoimidazo[4,5-h]isoquinolin-9-ones: Orally Active Inhibitors of lck Kinase
Goldberg, Daniel R, Butz, Tanja, Cardozo, Mario G, Eckner, Robert J, Hammach, Abdelhakim, Huang, Jessica, Jakes, Scott, Kapadia, Suresh, Kashem, Mohammed, Lukas, Susan, Morwick, Tina M, Panzenbeck, Maret, Patel, Usha, Pav, Susan, Peet, Gregory W, Peterson, Jeffrey D, Prokopowicz, Anthony S, Snow, Roger J, Sellati, Rosemarie, Takahashi, Hidenori, Tan, Jonathan, Tschantz, Matt A, Wang, Xiao-Jun, Wang, Yong, Wolak, John, Xiong, Pla, Moss, Neil
Published in Journal of medicinal chemistry (10.04.2003)
Published in Journal of medicinal chemistry (10.04.2003)
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Journal Article
Discovery and SAR of novel [1,6]Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)
Cywin, Charles L, Zhao, Bao-Ping, McNeil, Daniel W, Hrapchak, Matt, Prokopowicz, Anthony S, Goldberg, Daniel R, Morwick, Tina M, Gao, Amy, Jakes, Scott, Kashem, Mohammed, Magolda, Ronald L, Soll, Richard M, Player, Mark R, Bobko, Mark A, Rinker, James, DesJarlais, Renee L, Winters, Michael P
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
Published in Bioorganic & medicinal chemistry letters (17.04.2003)
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Journal Article
4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic Utility
Busacca, Carl A, Eriksson, Magnus C, Dong, Yong, Prokopowicz, Anthony S, Salvagno, Annette M, Tschantz, Matt A
Published in Journal of organic chemistry (11.06.1999)
Published in Journal of organic chemistry (11.06.1999)
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Journal Article
Evolution of the thienopyridine class of inhibitors of IkappaB kinase-beta: part I: hit-to-lead strategies
Morwick, Tina, Berry, Angela, Brickwood, Janice, Cardozo, Mario, Catron, Katrina, DeTuri, Molly, Emeigh, Jonathan, Homon, Carol, Hrapchak, Matt, Jacober, Stephen, Jakes, Scott, Kaplita, Paul, Kelly, Terence A, Ksiazek, John, Liuzzi, Michel, Magolda, Ronald, Mao, Can, Marshall, Daniel, McNeil, Daniel, Prokopowicz, 3rd, Anthony, Sarko, Christopher, Scouten, Erika, Sledziona, Cynthia, Sun, Sanxing, Watrous, Jane, Wu, Jiang Ping, Cywin, Charles L
Published in Journal of medicinal chemistry (18.05.2006)
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Published in Journal of medicinal chemistry (18.05.2006)
Journal Article
Evolution of the Thienopyridine Class of Inhibitors of IκB Kinase-β: Part I: Hit-to-Lead Strategies
Morwick, Tina, Berry, Angela, Brickwood, Janice, Cardozo, Mario, Catron, Katrina, DeTuri, Molly, Emeigh, Jonathan, Homon, Carol, Hrapchak, Matt, Jacober, Stephen, Jakes, Scott, Kaplita, Paul, Kelly, Terence A, Ksiazek, John, Liuzzi, Michel, Magolda, Ronald, Mao, Can, Marshall, Daniel, McNeil, Daniel, Prokopowicz, Anthony, Sarko, Christopher, Scouten, Erika, Sledziona, Cynthia, Sun, Sanxing, Watrous, Jane, Wu, Jiang Ping, Cywin, Charles L
Published in Journal of medicinal chemistry (18.05.2006)
Published in Journal of medicinal chemistry (18.05.2006)
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Journal Article
Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account
Wu, Frank, Büttner, Frank H., Chen, Rhonda, Hickey, Eugene, Jakes, Scott, Kaplita, Paul, Kashem, Mohammed A., Kerr, Steven, Kugler, Stanley, Paw, Zofia, Prokopowicz, Anthony, Shih, Cheng-Kon, Snow, Roger, Young, Erick, Cywin, Charles L.
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Substituted 2 H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats
Ginn, John D., Bosanac, Todd, Chen, Rhonda, Cywin, Charles, Hickey, Eugene, Kashem, Mohammed, Kerr, Steven, Kugler, Stanley, Li, Xiang, Prokopowicz, Anthony, Schlyer, Sabine, Smith, James D., Turner, Michael R., Wu, Frank, Young, Erick R.R.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Isoquinolinone synthesis by SNAr reaction: a versatile route to imidazo[4,5-h]isoquinolin-9-ones
Snow, RJ, Butz, T, Hammach, A, Kapadia, S, Morwick, TM, Prokopowicz, AS, Takahashi, H, Tan, JD, Tschantz, MA, Wang, XJ
Published in Tetrahedron letters (14.10.2002)
Published in Tetrahedron letters (14.10.2002)
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Journal Article
Isoquinolinone synthesis by S NAr reaction: a versatile route to imidazo[4,5- h]isoquinolin-9-ones
Snow, Roger J., Butz, Tanja, Hammach, Abdelhakim, Kapadia, Suresh, Morwick, Tina M., Prokopowicz, Anthony S., Takahashi, Hidenori, Tan, Jonathan D., Tschantz, Matt A., Wang, Xiao-Jun
Published in Tetrahedron letters (2002)
Published in Tetrahedron letters (2002)
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Journal Article
Rho kinase inhibitors
Liu, Weimin, Wu, Frank, Bosanac, Todd, Shih, Cheng-Kon, Young, Erick Richard, Ginn, John David, Turner, Michael Robert, Prokopowicz, Anthony S, Hickey, Eugene Richard, Schlyer, Sabine K, Snow, Roger John, Kirrane, Jr., Thomas Martin
Year of Publication 21.04.2020
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Year of Publication 21.04.2020
Patent
RHO KINASE INHIBITORS
BOSANAC, Todd, KIRRANE, Thomas, Martin, YOUNG, Erick, Richard, SHIH, Cheng-kon, SCHLYER, Sabine, K, LIU, Weimin, TURNER, Michael, Robert, HICKEY, Eugene, Richard, SNOW, Roger, John, PROKOPOWICZ, Anthony, S, WU, Frank, GINN, John, David
Year of Publication 10.04.2019
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Year of Publication 10.04.2019
Patent
RHO KINASE INHIBITORS
Liu, Weimin, Wu, Frank, Bosanac, Todd, Shih, Cheng-Kon, Young, Erick Richard, Kirrane, JR., Thomas Martin, Ginn, John David, Turner, Michael Robert, Prokopowicz, Anthony S, Hickey, Eugene Richard, Schlyer, Sabine K, Snow, Roger John
Year of Publication 06.12.2018
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Year of Publication 06.12.2018
Patent
Addition reactions of cyclic s-trans-enaminones with Grignard reagents
Shawe, Thomas T., Hansen, Darren B., Peet, Kelly Ann, Prokopowicz, Anthony S., Robinson, Patrice M., Cannon, Annatina, Dougherty, Kathleen E., Ross, Andrew A., Landino, Linda M.
Published in Tetrahedron (03.02.1997)
Published in Tetrahedron (03.02.1997)
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