Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)‑5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)
Osborne, James D, Matthews, Thomas P, McHardy, Tatiana, Proisy, Nicolas, Cheung, Kwai-Ming J, Lainchbury, Michael, Brown, Nathan, Walton, Michael I, Eve, Paul D, Boxall, Katherine J, Hayes, Angela, Henley, Alan T, Valenti, Melanie R, De Haven Brandon, Alexis K, Box, Gary, Jamin, Yann, Robinson, Simon P, Westwood, Isaac M, van Montfort, Rob L. M, Leonard, Philip M, Lamers, Marieke B. A. C, Reader, John C, Aherne, G. Wynne, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing
Reader, John C, Matthews, Thomas P, Klair, Suki, Cheung, Kwai-Ming J, Scanlon, Jane, Proisy, Nicolas, Addison, Glynn, Ellard, John, Piton, Nelly, Taylor, Suzanne, Cherry, Michael, Fisher, Martin, Boxall, Kathy, Burns, Samantha, Walton, Michael I, Westwood, Isaac M, Hayes, Angela, Eve, Paul, Valenti, Melanie, de Haven Brandon, Alexis, Box, Gary, van Montfort, Rob L. M, Williams, David H, Aherne, G. Wynne, Raynaud, Florence I, Eccles, Suzanne A, Garrett, Michelle D, Collins, Ian
Published in Journal of medicinal chemistry (22.12.2011)
Published in Journal of medicinal chemistry (22.12.2011)
Get full text
Journal Article
융합된 티오펜 유도체 및 이의 용도
MACHIN PETER, MELDRUM ERIC, MALAGU KARINE FABIENNE, PROISY NICOLAS, WINSHIP PAUL COLIN MICHAEL, LANARO ROBERTA, MACLEOD CALUM, CHAMBERS MARK, VESEY DAVID RICHARD, DE CHASSEY BENOIT
Year of Publication 18.12.2020
Get full text
Year of Publication 18.12.2020
Patent
Rapid Synthesis of 3-Aminoisoquinoline-5-sulfonamides Using the Buchwald-Hartwig Reaction
Proisy, Nicolas, Taylor, Stephen, Nelson, Andrew, Collins, Ian
Published in Synthesis (Stuttgart) (16.02.2009)
Published in Synthesis (Stuttgart) (16.02.2009)
Get more information
Journal Article
Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin
McErlean, Christopher S. P., Proisy, Nicolas, Davis, Christopher J., Boland, Nicola A., Sharp, Swee Y., Boxall, Kathy, Slawin, Alexandra M. Z., Workman, Paul, Moody, Christopher J.
Published in Organic & biomolecular chemistry (01.01.2007)
Published in Organic & biomolecular chemistry (01.01.2007)
Get more information
Journal Article
METHODS FOR SYNTHESIZING MOLYBDOPTERIN PRECURSOR Z DERIVATIVES
WATT DEREK KEVIN, PROISY NICOLAS GEORGES RENE, LONG XIANGTIAN, DAI DANMEI, LITTLE GILLIAN MARY, CLINCH KEITH, BAARS SYLVIA MYRNA, DIXON RACHEL ANNE, BRUNNER ANDREAS, LANDREAU CYRILLE ABEL SEBASTIEN
Year of Publication 17.01.2014
Get full text
Year of Publication 17.01.2014
Patent
Fused thiophene derivatives and their uses
Lanaro, Roberta, Vesey, David Robert, Machin, Peter, Macleod, Calum, Paparin, Jean-Laurent, De Chassey, Benoît, Malagu, Karine Fabienne, Chambers, Mark, Meldrum, Eric, Winship, Paul Colin Michael, Proisy, Nicolas
Year of Publication 14.03.2023
Get full text
Year of Publication 14.03.2023
Patent
Fused thiophene derivatives and their uses
MACLEOD, Calum, LANARO, Roberta, PROISY, Nicolas, VESEY, David Richard, WINSHIP, Paul Colin Michael, MACHIN, Peter, MELDRUM, Eric, DE CHASSEY, Benoît, MALAGU, Karine Fabienne, CHAMBERS, Mark
Year of Publication 02.02.2023
Get full text
Year of Publication 02.02.2023
Patent
Fused thiophene derivatives and their uses
Lanaro, Roberta, Vesey, David Robert, Machin, Peter, De Chassey, Benoît, Malagu, Karine Fabienne, Chambers, Mark, Meldrum, Eric, MacLeod, Calum, Winship, Paul Colin Michael, Proisy, Nicolas
Year of Publication 08.11.2022
Get full text
Year of Publication 08.11.2022
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
DE CHASSEY, BENOÎT, WINSHIP, PAUL COLIN MICHAEL, VESEY, DAVID RICHARD, CHAMBERS, MARK, MACLEOD, CALUM, MALAGU, KARINE FABIENNE, MELDRUM, ERIC, LANARO, ROBERTA, PROISY, NICOLAS, MACHIN, PETER
Year of Publication 19.11.2020
Get full text
Year of Publication 19.11.2020
Patent
Fused thiophene derivatives and their uses
MACLEOD, Calum, LANARO, Roberta, PROISY, Nicolas, VESEY, David Richard, WINSHIP, Paul Colin Michael, MACHIN, Peter, MELDRUM, Eric, DE CHASSEY, Benoît, MALAGU, Karine Fabienne, CHAMBERS, Mark
Year of Publication 06.08.2020
Get full text
Year of Publication 06.08.2020
Patent
METHODS FOR SYNTHESIZING MOLYBDOPTERIN PRECURSOR Z DERIVATIVES
DAI, DANMEI, BRUNNER, ANDREAS, DIXON, RACHEL ANNE, LITTLE, GILLIAN MARY, WATT, DEREK KEVIN, BAARS, SYLVIA MYRNA, LONG, XIANGTIAN, LANDREAU, CYRILLE ABEL SEBASTIEN, CLINCH, KEITH, PROISY, NICOLAS GEORGES RENE
Year of Publication 02.06.2020
Get full text
Year of Publication 02.06.2020
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
MACLEOD, Calum, LANARO, Roberta, PROISY, Nicolas, PAPARIN, Jean-Laurent, WINSHIP, Paul, Colin, Michael, MACHIN, Peter, VESEY, David, Richard, MELDRUM, Eric, MALAGU, Karine, Fabienne, DE CHASSEY, Benoît, CHAMBERS, Mark
Year of Publication 16.12.2020
Get full text
Year of Publication 16.12.2020
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
DE CHASSEY, BENOÎT, WINSHIP, PAUL COLIN MICHAEL, VESEY, DAVID RICHARD, CHAMBERS, MARK, MACLEOD, CALUM, PAPARIN, JEAN-LAURENT, MALAGU, KARINE FABIENNE, MELDRUM, ERIC, LANARO, ROBERTA, PROISY, NICOLAS, MACHIN, PETER
Year of Publication 26.11.2020
Get full text
Year of Publication 26.11.2020
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
MACLEOD, Calum, WINSHIP, Paul, LANARO, Roberta, PROISY, Nicolas, MALAGU, Karine, MACHIN, Peter, VESEY, David, MELDRUM, Eric, DE CHASSEY, Benoît, CHAMBERS, Mark
Year of Publication 15.08.2019
Get full text
Year of Publication 15.08.2019
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
WINSHIP, PAUL COLIN MICHAEL, VESEY, DAVID RICHARD, CHAMBERS, MARK, MACLEOD, CALUM, MALAGU, KARINE FABIENNE, MELDRUM, ERIC, LANARO, ROBERTA, PROISY, NICOLAS, MACHIN, PETER, DE CHASSEY, BENOIT
Year of Publication 15.08.2019
Get full text
Year of Publication 15.08.2019
Patent
FUSED THIOPHENE DERIVATIVES AND THEIR USES
MACLEOD, Calum, WINSHIP, Paul, LANARO, Roberta, PROISY, Nicolas, MALAGU, Karine, PAPARIN, Jean-Laurent, MACHIN, Peter, VESEY, David, MELDRUM, Eric, DE CHASSEY, Benoît, CHAMBERS, Mark
Year of Publication 15.08.2019
Get full text
Year of Publication 15.08.2019
Patent
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol
Proisy, Nicolas, Sharp, Swee Y, Boxall, Kathy, Connelly, Stephen, Roe, S Mark, Prodromou, Chrisostomos, Slawin, Alexandra M Z, Pearl, Laurence H, Workman, Paul, Moody, Christopher J
Published in Chemistry & biology (01.11.2006)
Published in Chemistry & biology (01.11.2006)
Get full text
Journal Article