HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models
Whitesell, Luke, Santagata, Sandro, Mendillo, Marc L., Lin, Nancy U., Proia, David A., Lindquist, Susan
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.12.2014)
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Mitochondrial electron transport is the cellular target of the oncology drug elesclomol
Blackman, Ronald K, Cheung-Ong, Kahlin, Gebbia, Marinella, Proia, David A, He, Suqin, Kepros, Jane, Jonneaux, Aurelie, Marchetti, Philippe, Kluza, Jerome, Rao, Patricia E, Wada, Yumiko, Giaever, Guri, Nislow, Corey
Published in PloS one (11.01.2012)
Published in PloS one (11.01.2012)
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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy
Ying, Weiwen, Du, Zhenjian, Sun, Lijun, Foley, Kevin P, Proia, David A, Blackman, Ronald K, Zhou, Dan, Inoue, Takayo, Tatsuta, Noriaki, Sang, Jim, Ye, Shuxia, Acquaviva, Jamie, Ogawa, Luisa Shin, Wada, Yumiko, Barsoum, James, Koya, Keizo
Published in Molecular cancer therapeutics (01.02.2012)
Published in Molecular cancer therapeutics (01.02.2012)
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Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer
Sang, Jim, Acquaviva, Jaime, Friedland, Julie C, Smith, Donald L, Sequeira, Manuel, Zhang, Chaohua, Jiang, Qin, Xue, Liquan, Lovly, Christine M, Jimenez, John-Paul, Shaw, Alice T, Doebele, Robert C, He, Suqin, Bates, Richard C, Camidge, D Ross, Morris, Stephan W, El-Hariry, Iman, Proia, David A
Published in Cancer discovery (01.04.2013)
Published in Cancer discovery (01.04.2013)
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Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer
Beck, Tim N., Korobeynikov, Vladislav A., Kudinov, Alexander E., Georgopoulos, Rachel, Solanki, Nehal R., Andrews-Hoke, Magda, Kistner, Timothy M., Pépin, David, Donahoe, Patricia K., Nicolas, Emmanuelle, Einarson, Margret B., Zhou, Yan, Boumber, Yanis, Proia, David A., Serebriiskii, Ilya G., Golemis, Erica A.
Published in Cell reports (Cambridge) (19.07.2016)
Published in Cell reports (Cambridge) (19.07.2016)
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Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD)
Nikonova, Anna S, Deneka, Alexander Y, Kiseleva, Anna A, Korobeynikov, Vladislav, Gaponova, Anna, Serebriiskii, Ilya G, Kopp, Meghan C, Hensley, Harvey H, Seeger-Nukpezah, Tamina N, Somlo, Stefan, Proia, David A, Golemis, Erica A
Published in The FASEB journal (01.05.2018)
Published in The FASEB journal (01.05.2018)
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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism
Acquaviva, Jaime, He, Suqin, Zhang, Chaohua, Jimenez, John-Paul, Nagai, Masazumi, Sang, Jim, Sequeira, Manuel, Smith, Donald L, Ogawa, Luisa Shin, Inoue, Takayo, Tatsuta, Noriaki, Knowles, Margaret A, Bates, Richard C, Proia, David A
Published in Molecular cancer research (01.07.2014)
Published in Molecular cancer research (01.07.2014)
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Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors
London, Cheryl A, Acquaviva, Jaime, Smith, Donald L, Sequeira, Manuel, Ogawa, Luisa Shin, Gardner, Heather L, Bernabe, Louis Feo, Bear, Misty D, Bechtel, Sandra A, Proia, David A
Published in Clinical cancer research (15.12.2018)
Published in Clinical cancer research (15.12.2018)
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mTOR inhibition potentiates HSP90 inhibitor activity via cessation of HSP synthesis
Acquaviva, Jaime, He, Suqin, Sang, Jim, Smith, Donald L, Sequeira, Manuel, Zhang, Chaohua, Bates, Richard C, Proia, David A
Published in Molecular cancer research (01.05.2014)
Published in Molecular cancer research (01.05.2014)
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Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease
Seeger-Nukpezah, Tamina, Proia, David A., Egleston, Brian L., Nikonova, Anna S., Kent, Tatiana, Cai, Kathy Q., Hensley, Harvey H., Ying, Weiwen, Chimmanamada, Dinesh, Serebriiskii, Ilya G., Golemis, Erica A.
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling
Proia, David A, Foley, Kevin P, Korbut, Tim, Sang, Jim, Smith, Don, Bates, Richard C, Liu, Yuan, Rosenberg, Alex F, Zhou, Dan, Koya, Keizo, Barsoum, James, Blackman, Ronald K
Published in PloS one (14.04.2011)
Published in PloS one (14.04.2011)
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Potent activity of the Hsp90 inhibitor ganetespib in prostate cancer cells irrespective of androgen receptor status or variant receptor expression
HE, SUQIN, ZHANG, CHAOHUA, SHAFI, AYESHA A, SEQUEIRA, MANUEL, ACQUAVIVA, JAIME, FRIEDLAND, JULIE C, SANG, JIM, SMITH, DONALD L, WEIGEL, NANCY L, WADA, YUMIKO, PROIA, DAVID A
Published in International journal of oncology (01.01.2013)
Published in International journal of oncology (01.01.2013)
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Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice
Smithline, Zachary B, Nikonova, Anna S, Hensley, Harvey H, Cai, Kathy Q, Egleston, Brian L, Proia, David A, Seeger-Nukpezah, Tamina, Golemis, Erica A
Published in PloS one (04.12.2014)
Published in PloS one (04.12.2014)
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Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespib
Acquaviva, Jaime, Smith, Donald L, Jimenez, John-Paul, Zhang, Chaohua, Sequeira, Manuel, He, Suqin, Sang, Jim, Bates, Richard C, Proia, David A
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Journal Article
Targeting KRAS-mutant non-small cell lung cancer with the Hsp90 inhibitor ganetespib
Acquaviva, Jaime, Smith, Donald L, Sang, Jim, Friedland, Julie C, He, Suqin, Sequeira, Manuel, Zhang, Chaohua, Wada, Yumiko, Proia, David A
Published in Molecular cancer therapeutics (01.12.2012)
Published in Molecular cancer therapeutics (01.12.2012)
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