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A Phase I/II Study of Evofosfamide, A Hypoxia-activated Prodrug with or without Bortezomib in Subjects with Relapsed/Refractory Multiple Myeloma
Laubach, Jacob P., Liu, Chia-Jen, Raje, Noopur S., Yee, Andrew J., Armand, Philippe, Schlossman, Robert L., Rosenblatt, Jacalyn, Hedlund, Jacquelyn, Martin, Michael, Reynolds, Craig, Shain, Kenneth H., Zackon, Ira, Stampleman, Laura, Henrick, Patrick, Rivotto, Bradley, Hornburg, Kalvis T.V., Dumke, Henry J., Chuma, Stacey, Savell, Alexandra, Handisides, Damian R., Kroll, Stew, Anderson, Kenneth C., Richardson, Paul G., Ghobrial, Irene M.
Published in Clinical cancer research (15.01.2019)
Published in Clinical cancer research (15.01.2019)
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Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects
Watanabe, Mai, Marcy, Brian, Kinoshita, Kohnosuke, Fukasawa, Misako, Hikichi, Hirohiko, Chaki, Shigeyuki, Okuyama, Shigeru, Gevorkyan, Hakop, Yoshida, Shigeru
Published in British Journal of Clinical Pharmacology (01.11.2020)
Published in British Journal of Clinical Pharmacology (01.11.2020)
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Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subjects and Its Antidepressant-Like Effects in Rodents
Watanabe, Mai, Marcy, Brian, Hiroki, Ayano, Watase, Hirotaka, Kinoshita, Kohnosuke, Iijima, Michihiko, Marumo, Toshiyuki, Zarate, Carlos A, Chaki, Shigeyuki
Published in International Journal of Neuropsychopharmacology (11.02.2022)
Published in International Journal of Neuropsychopharmacology (11.02.2022)
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Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis
Berliba, Elina, Bogus, Maxim, Vanhoutte, Frédéric, Berghmans, Pieter-Jan, Good, Steven S., Moussa, Adel, Pietropaolo, Keith, Murphy, Robert L., Zhou, Xiao-Jian, Sommadossi, Jean-Pierre
Published in Antimicrobial agents and chemotherapy (01.12.2019)
Published in Antimicrobial agents and chemotherapy (01.12.2019)
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Population pharmacokinetics and exposure-safety of lipophilic conjugates prodrug DP-VPA in healthy Chinese subjects for dose regime exploring
Li, Yi, Zhan, Huizhong, Wu, Jufang, Yu, Jicheng, Cao, Guoying, Wu, Xiaojie, Guo, Beining, Liu, Xiaofen, Fan, Yaxin, Hu, Jiali, Li, Xin, Wu, Hailan, Wang, Yu, Chen, Yuancheng, Xu, Xiaoyong, Yu, Peimin, Zhang, Jing
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2023)
Published in European journal of pharmaceutics and biopharmaceutics (01.07.2023)
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Tyrosinase-activated prodrug nanomedicine as oxidative stress amplifier for melanoma-specific treatment
Pu, Yinying, Zhou, Bangguo, Xiang, Huijing, Wu, Wencheng, Yin, Haohao, Yue, Wenwen, Yin, Yifei, Li, Hongyan, Chen, Yu, Xu, Huixiong
Published in Biomaterials (01.11.2020)
Published in Biomaterials (01.11.2020)
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Safety, tolerability, pharmacokinetics and clinical activity of AST-3424, an AKR1C3-activated bis-alkylating moiety prodrug, in subjects with advanced solid tumors in China: A phase I dose-escalation study
Li, Jin, Liu, Yunpeng, Luo, Suxia, Jieer, Ying, Pan, Hongming, Cai, Qichun, Guo, Ye, Xue, Junli, Teng, Zan, Shou, Jiawei, Xie, Yanbin, Duan, Jianxin, Wang, Ning, Shan, Qiuyue, Zhu, Qian, Li, Ye, Liu, Nan, Sun, Lin, Hao, Jing
Published in Journal of clinical oncology (01.06.2024)
Published in Journal of clinical oncology (01.06.2024)
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Safety, tolerability and pharmacokinetics of ASC10, a novel oral double prodrug of a broad-spectrum antiviral agent, β-d-N4-hydroxycytidine: results from a randomized, double-blind, placebo-controlled phase 1 study in Chinese healthy subjects
Liu, Jian, Zhao, Qingwei, Zhai, You, Wu, Xia, Kai, Jiejing, Ruan, Jie, Wu, Minglan, Wu, Meijia, Zhou, Zhuojun, Yan, Yuemei, Wu, Jinzi J, Qiu, Yunqing
Published in Expert opinion on investigational drugs (01.08.2024)
Published in Expert opinion on investigational drugs (01.08.2024)
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AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19
Good, Steven S., Westover, Jonna, Jung, Kie Hoon, Zhou, Xiao-Jian, Moussa, Adel, La Colla, Paolo, Collu, Gabriella, Canard, Bruno, Sommadossi, Jean-Pierre
Published in Antimicrobial agents and chemotherapy (18.03.2021)
Published in Antimicrobial agents and chemotherapy (18.03.2021)
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Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals
Owiredu, Shawn, Ranganathan, Abhay, Eckmann, David M., Shofer, Frances S., Hardy, Kevin, Lambert, David S., Kelly, Matthew, Jang, David H.
Published in American Journal of Physiology: Cell Physiology (01.07.2020)
Published in American Journal of Physiology: Cell Physiology (01.07.2020)
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Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects
Ishii, Yasuyuki, Ito, Yuko, Matsuki, Shunji, Sanpei, Kasumi, Ogawa, Osamu, Takeda, Kenji, Schuck, Edgar L., Uemura, Naoto
Published in Clinical and translational science (01.09.2018)
Published in Clinical and translational science (01.09.2018)
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Phase 1 safety, tolerability, pharmacokinetics and pharmacodynamics results of a long‐acting C‐type natriuretic peptide prodrug, TransCon CNP
Breinholt, Vibeke Miller, Mygind, Per Holse, Christoffersen, Eva Dam, Zhang, Ying, Ota, Sho, Will Charlton, R., Viuff, Dorthe
Published in British journal of clinical pharmacology (01.11.2022)
Published in British journal of clinical pharmacology (01.11.2022)
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2157. Phase 1 Study in Healthy Chinese Subjects of Novel Prodrug, MRX-4
Yang, Haijing, Li, Size, Wang, Hailin, Cao, Guoying, Zhang, Jing
Published in Open forum infectious diseases (27.11.2023)
Published in Open forum infectious diseases (27.11.2023)
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Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy
Zheng, Shunzhe, Li, Guanting, Shi, Jianbin, Liu, Xinying, Li, Meng, He, Zhonggui, Tian, Chutong, Kamei, Ken-ichiro
Published in Journal of Controlled Release (01.09.2023)
Published in Journal of Controlled Release (01.09.2023)
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Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis
Berliba, Elina, Bogus, Maxim, Vanhoutte, Frédéric, Berghmans, Pieter-Jan, Good, Steven S, Moussa, Adel, Pietropaolo, Keith, Murphy, Robert L, Zhou, Xiao-Jian, Sommadossi, Jean-Pierre
Published in Antimicrobial agents and chemotherapy (09.09.2019)
Published in Antimicrobial agents and chemotherapy (09.09.2019)
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First-In-Human Study on Pharmacokinetics, Safety, and Tolerability of Single and Multiple Escalating Doses of Hepenofovir, a Novel Hepatic Targeting Prodrug of Tenofovir in Healthy Chinese Subjects
Zhang, Hong, Gao, Lei, Lou, Jinfeng, Wu, Min, Chen, Hong, Yang, Lizhi, Liu, Jingrui, Zhu, Xiaoxue, Li, Xiaojiao, Li, Cuiyun, Wang, Meng, Liu, Chengjiao, Guo, Weibo, Wang, Yuan, Gao, Zhongqiang, Han, Lei, Wang, Daidi, Jin, Weili, Ding, Yanhua
Published in Frontiers in Pharmacology (19.05.2022)
Published in Frontiers in Pharmacology (19.05.2022)
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A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects
Mungur, Ounisha, Berliba, Elina, Bourgeois, Stefan, Cardona, Marine, Jucov, Alina, Good, Steven, Moussa, Adel, Pietropaolo, Keith, Zhou, Xiao-Jian, Brown, Nathaniel, Sommadossi, Jean-Pierre
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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THU438 - A combination of AT-527, a pan-genotypic guanosine nucleotide prodrug, and daclatasvir was well-tolerated and effective in HCV-infected subjects
Mungur, Ounisha, Berliba, Elina, Bourgeois, Stefan, Cardona, Marine, Jucov, Alina, Good, Steven, Moussa, Adel, Pietropaolo, Keith, Zhou, Xiao-Jian, Brown, Nathaniel, Sommadossi, Jean-Pierre
Published in Journal of hepatology (01.08.2020)
Published in Journal of hepatology (01.08.2020)
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