922 A novel autotaxin inhibitor, IOA-289, modulates tumor, immune and stromal cell function and has monotherapy activity in fibrotic cancer models
Deken, Marcel, Niewola, Karolina, Matas-Rico, Elisa, Medhi, Ragini, Carruthers, Alan, Cheasty, Anne, Peyruchaud, Olivier, Fraser, Amy, Shah, Pritom, Moolenaar, Wouter, Veen, Lars van der, Lahn, Michael, Johnson, Zoe
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
Discovery of potent inhibitors of the lyso phospholipase autotaxin
Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
Published in Bioorganic & medicinal chemistry letters (01.11.2016)
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Journal Article
Abstract 1877: IOA-237 - A potent anti-CD73 mAb demonstrates monotherapeutic and combination efficacy in solid tumor models
Deken, Marcel A., Carruthers, Alan M., Niewola-Staszkowska, Karolina, Gernon, Gráinne, Sandig, Hilary, Shah, Pritom, Lahn, Michael M., Johnson, Zoë
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 5660: Characterisation of novel CD73 antibodies as a therapeutic method of adenosine regulation
Gernon, Grainne, Grooby, Suzanne, Tonkin, Louise, Bitterwolf, Anja-Christina, Stewart, Lorna, Deken, Marcel, Shah, Pritom, Ewings, Katherine, Johnson, Zoe
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 2692: Preclinical development of a novel, highly selective PI3Kδ inhibitor, IOA-244, for the treatment of solid malignancies
Ewings, Katherine, MacQueen, Amy, Shah, Pritom, Tsapara, Anna, Papakonstanti, Evangelia, Veen, Lars van der, Lahn, Michael, Johnson, Zoe
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract 666: A novel, highly selective PI3Kδ inhibitor for the treatment of solid malignancies that express high levels of target protein as assessed by immunohistochemistry
MacQueen, Amy R., Viticchie, Giuditta, Niewola, Karolina, Finotello, Francesca, Powley, Ian, Shah, Pritom, van der Veen, Lars, Lahn, Michael, Johnson, Zoe
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Discovery of potent inhibitors of the lysophospholipase autotaxin
Shah, Pritom, Cheasty, Anne, Foxton, Caroline, Raynham, Tony, Farooq, Muddasar, Gutierrez, Irene Farre, Lejeune, Aurore, Pritchard, Michelle, Turnbull, Andrew, Pang, Leon, Owen, Paul, Boyd, Susan, Stowell, Alexandra, Jordan, Allan, Hamilton, Niall M., Hitchin, James R., Stockley, Martin, MacDonald, Ellen, Quesada, Mar Jimenez, Trivier, Elisabeth, Skeete, Jana, Ovaa, Huib, Moolenaar, Wouter H., Ryder, Hamish
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
Published in Bioorganic & medicinal chemistry letters (15.11.2016)
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Journal Article
IOA-244 is a Non-ATP-competitive, Highly Selective, Tolerable PI3K Delta Inhibitor That Targets Solid Tumors and Breaks Immune Tolerance
Johnson, Zoë, Tarantelli, Chiara, Civanelli, Elisa, Cascione, Luciano, Spriano, Filippo, Fraser, Amy, Shah, Pritom, Nomanbhoy, Tyzoon, Napoli, Sara, Rinaldi, Andrea, Niewola-Staszkowska, Karolina, Lahn, Michael, Perrin, Dominique, Wenes, Mathias, Migliorini, Denis, Bertoni, Francesco, van der Veen, Lars, Di Conza, Giusy
Published in Cancer research communications (14.04.2023)
Published in Cancer research communications (14.04.2023)
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Journal Article
889 IOA-244 is a non-ATP-competitive, highly selective, tolerable phosphoinositide 3-kinase delta inhibitor that directly targets solid tumours and breaks immune tolerance
Giusy Di Conza, Van der Veen, Lars, Tarantelli, Chiara, Bertoni, Francesco, Fraser, Amy, Shah, Pritom, Tiede, Simon, Tesmer, Laura, Hummer, Gerhard, Vadas, Oscar, Lahn, Michael, Tyzoonn, Nomanbhoy, Johnson, Zoe
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Abstract 2636: Targeting Autotaxin to suppress stromal signaling in the tumor microenvironment to improve outcome to therapy in fibrotic tumor types
Johnson, Zoe, Deken, Marcel, Medhi, Ragini, Maggs, Lauren, Carruthers, Alan, Cheasty, Anne, Tagliavini, Alessia, Nizzardo, Andrea, Pergher, Marco, Niewola, Karolina, Fraser, Amy, van der Veen, Lars, Shah, Pritom, ZIviani, Luigi, Milleri, Stefano, Lahn, Michael
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate
Slater, Martin J, Amphlett, Elizabeth M, Andrews, David M, Bravi, Gianpaolo, Burton, George, Cheasty, Anne G, Corfield, John A, Ellis, Malcolm R, Fenwick, Rebecca H, Fernandes, Stephanie, Guidetti, Rossella, Haigh, David, Hartley, C. David, Howes, Peter D, Jackson, Deborah L, Jarvest, Richard L, Lovegrove, Victoria L. H, Medhurst, Katrina J, Parry, Nigel R, Price, Helen, Shah, Pritom, Singh, Onkar M. P, Stocker, Richard, Thommes, Pia, Wilkinson, Claire, Wonacott, Alan
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Journal Article
Discovery of Further Pyrrolidine trans-Lactams as Inhibitors of Human Neutrophil Elastase (HNE) with Potential as Development Candidates and the Crystal Structure of HNE Complexed with an Inhibitor (GW475151)
Macdonald, Simon J. F, Dowle, Michael D, Harrison, Lee A, Clarke, Geoffrey D. E, Inglis, Graham G. A, Johnson, Martin R, Shah, Pritom, Smith, Robin A, Amour, Augustin, Fleetwood, Gill, Humphreys, Davina C, Molloy, Christopher R, Dixon, Mary, Godward, Rosalind E, Wonacott, Alan J, Singh, Onkar M. P, Hodgson, Simon T, Hardy, George W
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Journal Article
AUTOTAXIN INHIBITORY COMPOUNDS
HITCHIN, James, HAMILTON, Niall, MACDONALD, Ellen Catherine, SHAH, Pritom, STOCKLEY, Martin Lee, JORDAN, Allan
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
Patent
AUTOTAXIN INHIBITORY COMPOUNDS
SHAH, PRITOM, STOCKLEY, MARTIN LEE, HITCHIN, JAMES, JORDAN, ALLAN, MACDONALD, ELLEN CATHERINE, HAMILTON, NIALL
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
Patent
AUTOTAXIN INHIBITORS
SHAH, PRITOM, FARRE GUTIERREZ, IRENE, CARR, JAMES LINDSAY, BLUM, FRANCESCA, DEL MAR JIMENEZ QUESADA, MARIA
Year of Publication 28.03.2023
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Year of Publication 28.03.2023
Patent