Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription
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Published in Molecular cell (08.08.2013)
Published in Molecular cell (08.08.2013)
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Published in The Journal of experimental medicine (02.07.2018)
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Published in Science (American Association for the Advancement of Science) (24.04.2020)
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Published in Nature chemical biology (01.03.2015)
Published in Nature chemical biology (01.03.2015)
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Published in The Journal of biological chemistry (16.02.2018)
Published in The Journal of biological chemistry (16.02.2018)
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Published in Annals of the rheumatic diseases (01.02.2016)
Published in Annals of the rheumatic diseases (01.02.2016)
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Discovery of I‑BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
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Published in Journal of medicinal chemistry (25.02.2016)
Published in Journal of medicinal chemistry (25.02.2016)
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Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
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Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2020)
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Published in Nature communications (20.06.2019)
Published in Nature communications (20.06.2019)
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Discovery of Epigenetic Regulator I‑BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
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Published in Journal of medicinal chemistry (10.10.2013)
Published in Journal of medicinal chemistry (10.10.2013)
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BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor models
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Published in PloS one (23.08.2013)
Published in PloS one (23.08.2013)
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Published in Science (American Association for the Advancement of Science) (30.06.2017)
Published in Science (American Association for the Advancement of Science) (30.06.2017)
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Suppression of the antiviral response by an influenza histone mimic
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Published in Nature (London) (22.03.2012)
Published in Nature (London) (22.03.2012)
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Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762
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Published in Blood (30.01.2014)
Published in Blood (30.01.2014)
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Selective inhibition of CD4⁺ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
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Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (04.09.2012)
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SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
Tzelepis, Konstantinos, De Braekeleer, Etienne, Aspris, Demetrios, Barbieri, Isaia, Vijayabaskar, M. S., Liu, Wen-Hsin, Gozdecka, Malgorzata, Metzakopian, Emmanouil, Toop, Hamish D., Dudek, Monika, Robson, Samuel C., Hermida-Prado, Francisco, Yang, Yu Hsuen, Babaei-Jadidi, Roya, Garyfallos, Dimitrios A., Ponstingl, Hannes, Dias, Joao M. L., Gallipoli, Paolo, Seiler, Michael, Buonamici, Silvia, Vick, Binje, Bannister, Andrew J., Rad, Roland, Prinjha, Rab K., Marioni, John C., Huntly, Brian, Batson, Jennifer, Morris, Jonathan C., Pina, Cristina, Bradley, Allan, Jeremias, Irmela, Bates, David O., Yusa, Kosuke, Kouzarides, Tony, Vassiliou, George S.
Published in Nature communications (19.12.2018)
Published in Nature communications (19.12.2018)
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Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation
Park-Min, Kyung-Hyun, Lim, Elisha, Lee, Min Joon, Park, Sung Ho, Giannopoulou, Eugenia, Yarilina, Anna, van der Meulen, Marjolein, Zhao, Baohong, Smithers, Nicholas, Witherington, Jason, Lee, Kevin, Tak, Paul P., Prinjha, Rab K., Ivashkiv, Lionel B
Published in Nature communications (13.11.2014)
Published in Nature communications (13.11.2014)
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Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters
Robles-Rebollo, Irene, Cuartero, Sergi, Canellas-Socias, Adria, Wells, Sarah, Karimi, Mohammad M., Mereu, Elisabetta, Chivu, Alexandra G., Heyn, Holger, Whilding, Chad, Dormann, Dirk, Marguerat, Samuel, Rioja, Inmaculada, Prinjha, Rab K., Stumpf, Michael P. H., Fisher, Amanda G., Merkenschlager, Matthias
Published in Nature communications (27.07.2022)
Published in Nature communications (27.07.2022)
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The Discovery of I‑BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor
Gosmini, Romain, Nguyen, Van Loc, Toum, Jérôme, Simon, Christophe, Brusq, Jean-Marie G, Krysa, Gael, Mirguet, Olivier, Riou-Eymard, Alizon M, Boursier, Eric V, Trottet, Lionel, Bamborough, Paul, Clark, Hugh, Chung, Chun-wa, Cutler, Leanne, Demont, Emmanuel H, Kaur, Rejbinder, Lewis, Antonia J, Schilling, Mark B, Soden, Peter E, Taylor, Simon, Walker, Ann L, Walker, Matthew D, Prinjha, Rab K, Nicodème, Edwige
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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