C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN
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Published in Journal of the American Society of Nephrology (01.02.2014)
Published in Journal of the American Society of Nephrology (01.02.2014)
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Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers
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Published in Investigational new drugs (01.08.2019)
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CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
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Published in Blood (16.08.2012)
Published in Blood (16.08.2012)
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Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes
Sullivan, Timothy J, Miao, Zhenhua, Zhao, Bin N, Ertl, Linda S, Wang, Yu, Krasinski, Antoni, Walters, Matthew J, Powers, Jay P, Dairaghi, Daniel J, Baumgart, Trageen, Seitz, Lisa C, Berahovich, Robert D, Schall, Thomas J, Jaen, Juan C
Published in Metabolism, clinical and experimental (01.11.2013)
Published in Metabolism, clinical and experimental (01.11.2013)
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Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39
Jeffrey, Jenna L, Lawson, Kenneth V, Powers, Jay P
Published in Journal of medicinal chemistry (25.11.2020)
Published in Journal of medicinal chemistry (25.11.2020)
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CCR9 Antagonists in the Treatment of Ulcerative Colitis
Sullivan, Timothy J., Jaen, Juan C., Schall, Thomas J., Powers, Jay P., Punna, Sreenivas, Charvat, Trevor T., Ertl, Linda S., Berahovich, Robert D., Walters, Matthew J., Ebsworth, Karen, Bekker, Pirow, Campbell, James J.
Published in Mediators of Inflammation (01.01.2015)
Published in Mediators of Inflammation (01.01.2015)
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Discovery of AB680: A Potent and Selective Inhibitor of CD73
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Published in Journal of medicinal chemistry (22.10.2020)
Published in Journal of medicinal chemistry (22.10.2020)
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Targeting CD73 with AB680 (Quemliclustat), a Novel and Potent Small-Molecule CD73 Inhibitor, Restores Immune Functionality and Facilitates Antitumor Immunity
Piovesan, Dana, Tan, Joanne B L, Becker, Annette, Banuelos, Jesus, Narasappa, Nell, DiRenzo, Daniel, Zhang, Kristen, Chen, Ada, Ginn, Elaine, Udyavar, Akshata R, Yin, Fangfang, Paprcka, Susan L, Purandare, Bhamini, Park, Timothy W, Kimura, Nikki, Kalisiak, Jaroslaw, Young, Stephen W, Powers, Jay P, Schindler, Uli, Sivick, Kelsey E, Walters, Matthew J
Published in Molecular cancer therapeutics (01.06.2022)
Published in Molecular cancer therapeutics (01.06.2022)
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Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73
Beatty, Joel W, Lindsey, Erick A, Thomas-Tran, Rhiannon, Debien, Laurent, Mandal, Debashis, Jeffrey, Jenna L, Tran, Anh T, Fournier, Jeremy, Jacob, Steven D, Yan, Xuelei, Drew, Samuel L, Ginn, Elaine, Chen, Ada, Pham, Amber T, Zhao, Sharon, Jin, Lixia, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Moschütz, Susanne, Sträter, Norbert, Powers, Jay P, Lawson, Kenneth V
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors
Sharif, Ehesan U., Kalisiak, Jaroslaw, Lawson, Kenneth, Miles, Dillon H., Newcomb, Eric, Lindsey, Erick A., Rosen, Brandon R., Debien, Laurent P. P., Chen, Ada, Zhao, Xiaoning, Young, Stephen W., Walker, Nigel P., Straeter, Norbert, Scaletti, Emma R., Jin, Lixia, Xu, Guifen, Leleti, Manmohan R., Powers, Jay P.
Published in Journal of medicinal chemistry (14.01.2021)
Published in Journal of medicinal chemistry (14.01.2021)
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Discovery of Potent and Selective PI3Kγ Inhibitors
Drew, Samuel L, Thomas-Tran, Rhiannon, Beatty, Joel W, Fournier, Jeremy, Lawson, Kenneth V, Miles, Dillon H, Mata, Guillaume, Sharif, Ehesan U, Yan, Xuelei, Mailyan, Artur K, Ginn, Elaine, Chen, Jie, Wong, Kent, Soni, Divyank, Dhanota, Puja, Chen, Pei-Yu, Shaqfeh, Stefan G, Meleza, Cesar, Pham, Amber T, Chen, Ada, Zhao, Xiaoning, Banuelos, Jesus, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (08.10.2020)
Published in Journal of medicinal chemistry (08.10.2020)
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Design, Synthesis, and Structure-Activity Relationship Optimization of Pyrazolopyrimidine Amide Inhibitors of Phosphoinositide 3-Kinase γ (PI3Kγ)
Mata, Guillaume, Miles, Dillon H, Drew, Samuel L, Fournier, Jeremy, Lawson, Kenneth V, Mailyan, Artur K, Sharif, Ehesan U, Yan, Xuelei, Beatty, Joel W, Banuelos, Jesus, Chen, Jie, Ginn, Elaine, Chen, Ada, Gerrick, Kimberline Y, Pham, Amber T, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Narasappa, Nell, Singh, Hema, Zhao, Xiaoning, Jin, Lixia, Schindler, Ulrike, Walters, Matthew J, Young, Stephen W, Walker, Nigel P, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Rational Design and Binding Mode Duality of MDM2–p53 Inhibitors
Gonzalez-Lopez de Turiso, Felix, Sun, Daqing, Rew, Yosup, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Correll, Tiffany L, Huang, Xin, Julian, Lisa D, Kayser, Frank, Lo, Mei-Chu, Long, Alexander M, McMinn, Dustin, Oliner, Jonathan D, Osgood, Tao, Powers, Jay P, Saiki, Anne Y, Schneider, Steve, Shaffer, Paul, Xiao, Shou-Hua, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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Crystal Structures of IRAK-4 Kinase in Complex with Inhibitors: A Serine/Threonine Kinase with Tyrosine as a Gatekeeper
Wang, Zhulun, Liu, Jinsong, Sudom, Athena, Ayres, Merrill, Li, Shyun, Wesche, Holger, Powers, Jay P., Walker, Nigel P.C.
Published in Structure (London) (01.12.2006)
Published in Structure (London) (01.12.2006)
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Discovery of Potent and Selective 7‑Azaindole Isoindolinone-Based PI3Kγ Inhibitors
Miles, Dillon H, Yan, Xuelei, Thomas-Tran, Rhiannon, Fournier, Jeremy, Sharif, Ehesan U, Drew, Samuel L, Mata, Guillaume, Lawson, Kenneth V, Ginn, Elaine, Wong, Kent, Soni, Divyank, Dhanota, Puja, Shaqfeh, Stefan G, Meleza, Cesar, Chen, Ada, Pham, Amber T, Park, Timothy, Swinarski, Debbie, Banuelos, Jesus, Schindler, Ulrike, Walters, Matthew J, Walker, Nigel P, Zhao, Xiaoning, Young, Stephen W, Chen, Jie, Jin, Lixia, Leleti, Manmohan Reddy, Powers, Jay P, Jeffrey, Jenna L
Published in ACS medicinal chemistry letters (12.11.2020)
Published in ACS medicinal chemistry letters (12.11.2020)
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SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase
Powers, Jay P, Piper, Derek E, Li, Yang, Mayorga, Veronica, Anzola, John, Chen, James M, Jaen, Juan C, Lee, Gary, Liu, Jinqian, Peterson, M. Greg, Tonn, George R, Ye, Qiuping, Walker, Nigel P. C, Wang, Zhulun
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Discovery of potent, selective, and orally bioavailable inhibitors of interleukin-1 receptor-associate kinase-4
Wang, Zhulun, Sun, Daqing, Johnstone, Sheree, Cao, Zhaodan, Gao, Xiong, Jaen, Juan C., Liu, Jingqian, Lively, Sarah, Miao, Shichang, Sudom, Athena, Tomooka, Craig, Walker, Nigel P.C., Wright, Matthew, Yan, Xuelei, Ye, Qiuping, Powers, Jay P.
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
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ITOC2 – 011. Identification of second-generation potent and selective inhibitors of indoleamine-2,3-dioxygenase-1 (IDO1) for the treatment of cancer
Juan, Jaen C, Pia, Bjorck, Jordan, Fridman S, Lisa, Marshall, Jan, Melom, Rajkumar, Noubade, Max, Osipov, Matthew, Walters J, Mikhail, Zibinsky, Jay, Powers P
Published in European journal of cancer (1990) (01.03.2015)
Published in European journal of cancer (1990) (01.03.2015)
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