Functional deficit in hippocampal activity during fear extinction recall in the single prolonged-stress model of PTSD in male rats
Winters, Jesse J., Hardy, Larry W., Sullivan, Jenna M., Powell, Noel A., Qutaish, Mohammed, Nair, Surabhi, Heimann, Jack, Ghayoor, Ali, Polyak, Ildiko, Chaby, Lauren, Rodriguez, Elizabeth, Chaar, Dima, Oscherwitz, Jon, Liberzon, Israel
Published in Behavioural brain research (01.01.2021)
Published in Behavioural brain research (01.01.2021)
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Journal Article
Discovery of biaryls as RORγ inverse agonists by using structure-based design
Enyedy, Istvan J., Powell, Noel A., Caravella, Justin, van Vloten, Kurt, Chao, Jianhua, Banerjee, Daliya, Marcotte, Douglas, Silvian, Laura, McKenzie, Andres, Hong, Victor Sukbong, Fontenot, Jason D.
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
Published in Bioorganic & medicinal chemistry letters (15.05.2016)
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Journal Article
Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand
Marcotte, Douglas J, Liu, YuTing, Little, Kevin, Jones, John H, Powell, Noel A, Wildes, Craig P, Silvian, Laura F, Chodaparambil, Jayanth V
Published in BMC structural biology (01.06.2016)
Published in BMC structural biology (01.06.2016)
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Journal Article
Novel and selective spiroindoline-based inhibitors of sky kinase
Powell, Noel A., Kohrt, Jeffrey T., Filipski, Kevin J., Kaufman, Michael, Sheehan, Derek, Edmunds, Jeremy E., Delaney, Amy, Wang, Yuli, Bourbonais, Francis, Lee, Doh-Yeel, Schwende, Frank, Sun, Fang, McConnell, Pat, Catana, Cornel, Chen, Huifen, Ohren, Jeff, Perrin, Lisa A.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ
Casimiro-Garcia, Agustin, Heemstra, Ronald J., Bigge, Christopher F., Chen, Jing, Ciske, Fred A., Davis, Jo Ann, Ellis, Teresa, Esmaeil, Nadia, Flynn, Declan, Han, Seungil, Jalaie, Mehran, Ohren, Jeffrey F., Powell, Noel A.
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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Journal Article
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
Powell, Noel A., Hoffman, Jennifer K., Ciske, Fred L., Kaufman, Michael D., Kohrt, Jeffrey T., Quin, John, Sheehan, Derek J., Delaney, Amy, Baxi, Sangita M., Catana, Cornel, McConnell, Patrick, Ohren, Jeff, Perrin, Lisa A., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
Published in Bioorganic & medicinal chemistry letters (15.02.2013)
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Journal Article
Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors
Powell, Noel A., Ciske, Fred L., Cai, Cuiman, Holsworth, Daniel D., Mennen, Ken, Van Huis, Chad A., Jalaie, Mehran, Day, Jacqueline, Mastronardi, Michelle, McConnell, Pat, Mochalkin, Igor, Zhang, Erli, Ryan, Michael J., Bryant, John, Collard, Wendy, Ferreira, Suzie, Gu, Chungang, Collins, Roxane, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.09.2007)
Published in Bioorganic & medicinal chemistry (01.09.2007)
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Journal Article
Binding thermodynamics of substituted diaminopyrimidine renin inhibitors
Sarver, Ronald W., Peevers, Jeanette, Cody, Wayne L., Ciske, Fred L., Dyer, Jim, Emerson, S. Donald, Hagadorn, Jeanne C., Holsworth, Daniel D., Jalaie, Mehran, Kaufman, Michael, Mastronardi, Michelle, McConnell, Patrick, Powell, Noel A., Quin, John, Van Huis, Chad A., Zhang, Erli, Mochalkin, Igor
Published in Analytical biochemistry (2007)
Published in Analytical biochemistry (2007)
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Journal Article
Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors
Holsworth, Daniel D., Jalaie, Mehran, Belliotti, Thomas, Cai, Cuiman, Collard, Wendy, Ferreira, Suzie, Powell, Noel A., Stier, Michael, Zhang, Erli, McConnell, Pat, Mochalkin, Igor, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Subedi, Rajendra, Maiti, Samarendra N., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
Published in Bioorganic & medicinal chemistry letters (01.07.2007)
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Journal Article
Total Synthesis of Formamicin
Durham, Timothy B, Blanchard, Nicolas, Savall, Brad M, Powell, Noel A, Roush, William R
Published in Journal of the American Chemical Society (04.08.2004)
Published in Journal of the American Chemical Society (04.08.2004)
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Journal Article
Ketopiperazine-based renin inhibitors: Optimization of the “C” ring
Holsworth, Daniel D., Cai, Cuiman, Cheng, Xue-Min, Cody, Wayne L., Downing, Dennis M., Erasga, Noe, Lee, Chitase, Powell, Noel A., Edmunds, Jeremy J., Stier, Michael, Jalaie, Mehran, Zhang, Erli, McConnell, Pat, Ryan, Michael J., Bryant, John, Li, Tingsheng, Kasani, Aparna, Hall, Eric, Subedi, Rajendra, Rahim, Mohammad, Maiti, Samarendra
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Journal Article
The discovery and preparation of disubstituted novel amino-aryl-piperidine-based renin inhibitors
Cody, Wayne L., Holsworth, Daniel D., Powell, Noel A., Jalaie, Mehran, Zhang, Erli, Wang, Wei, Samas, Brian, Bryant, John, Ostroski, Robert, Ryan, Michael J., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (03.01.2005)
Published in Bioorganic & medicinal chemistry (03.01.2005)
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Journal Article
Discovery of novel non-peptidic ketopiperazine-based renin inhibitors
Holsworth, Daniel D., Powell, Noel A., Downing, Dennis M., Cai, Cuiman, Cody, Wayne L., Ryan, J. Michael, Ostroski, Robert, Jalaie, Mehran, Bryant, John W., Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry (01.04.2005)
Published in Bioorganic & medicinal chemistry (01.04.2005)
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Journal Article
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors
Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors
Powell, Noel A., Clay, Emma H., Holsworth, Daniel D., Bryant, John W., Ryan, Michael J., Jalaie, Mehran, Zhang, Erli, Edmunds, Jeremy J.
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
Published in Bioorganic & medicinal chemistry letters (02.05.2005)
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Journal Article
An improved method for the synthesis of enantiomerically pure amino acid ester isocyanates
Nowick, James S, Powell, Noel A, Nguyen, Tram M, Noronha, Glenn
Published in Journal of organic chemistry (01.12.1992)
Published in Journal of organic chemistry (01.12.1992)
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Journal Article
Practical Synthesis of 1-Aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo Amide−Epoxide Cyclization
Powell, Noel A, Ciske, Fred L, Clay, Emma C, Cody, Wayne L, Downing, Dennis M, Blazecka, Peter G, Holsworth, Daniel D, Edmunds, Jeremy J
Published in Organic letters (28.10.2004)
Published in Organic letters (28.10.2004)
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Journal Article