Contribution of a mutational bias in hepatitis C virus replication to the genetic barrier in the development of drug resistance
Powdrill, Megan H, Tchesnokov, Egor P, Kozak, Robert A, Russell, Rodney S, Martin, Ross, Svarovskaia, Evguenia S, Mo, Hongmei, Kouyos, Roger D, Götte, Matthias
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (20.12.2011)
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Journal Article
A Bifunctional Nucleoside Probe for the Inhibition of the Human Immunodeficiency Virus-Type 1 Reverse Transcriptase
Shaw, Tyler A, Ablenas, Christopher J, Desrochers, Geneviève F, Powdrill, Megan H, Bilodeau, Didier A, Vincent-Rocan, Jean-François, Niu, Meijuan, Monette, Anne, Mouland, Andrew J, Beauchemin, André M, Pezacki, John Paul
Published in Bioconjugate chemistry (20.05.2020)
Published in Bioconjugate chemistry (20.05.2020)
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Journal Article
Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B
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Journal Article
Book Review
MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis
Shaw, Tyler A, Singaravelu, Ragunath, Powdrill, Megan H, Nhan, Jordan, Ahmed, Nadine, Özcelik, Dennis, Pezacki, John Paul
Published in iScience (21.12.2018)
Published in iScience (21.12.2018)
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Journal Article
Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase
MARTIN BERKE, Jan, VIJGEN, Leen, VAN DEN EYNDE, Christel, LECLERCQ, Laurent, JONCKERS, Tim H. M, RABOISSON, Pierre, NILSSON, Magnus, SAMUELSSON, Bertil, ROSENQUIST, Asa, FANNING, Gregory C, LIN, Tse-I, LACHAU-DURAND, Sophie, POWDRILL, Megan H, RAWE, Svea, SJUVARSSON, Elena, ERIKSSON, Staffan, GÖTTE, Matthias, FRANSEN, Els, DEHERTOGH, Pascale
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
Published in Antimicrobial Agents and Chemotherapy (01.08.2011)
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Journal Article
MicroRNA-7 mediates cross-talk between metabolic signaling pathways in the liver
Singaravelu, Ragunath, Quan, Curtis, Powdrill, Megan H, Shaw, Tyler A, Srinivasan, Prashanth, Lyn, Rodney K, Alonzi, Rhea C, Jones, Daniel M, Filip, Roxana, Russell, Rodney S, Pezacki, John P
Published in Scientific reports (10.01.2018)
Published in Scientific reports (10.01.2018)
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Journal Article
Dynamics of Hepatitis C Virus (HCV) RNA-dependent RNA Polymerase NS5B in Complex with RNA
Karam, Pierre, Powdrill, Megan H., Liu, Hsiao-Wei, Vasquez, Colins, Mah, Wayne, Bernatchez, Jean, Götte, Matthias, Cosa, Gonzalo
Published in The Journal of biological chemistry (16.05.2014)
Published in The Journal of biological chemistry (16.05.2014)
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Journal Article
The role of microRNAs in metabolic interactions between viruses and their hosts
Powdrill, Megan H, Desrochers, Geneviève F, Singaravelu, Ragunath, Pezacki, John Paul
Published in Current opinion in virology (01.08.2016)
Published in Current opinion in virology (01.08.2016)
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Journal Article
Reactivity of N -acyl hydrazone probes with the mammalian proteome
Shaw, Tyler A, Powdrill, Megan H, Sherratt, Allison R, Garland, Keira, Li, Bin-Jie, Beauchemin, André M, Pezacki, John Paul
Published in MedChemComm (26.05.2021)
Published in MedChemComm (26.05.2021)
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Journal Article
Hydrophobic Triaryl-Substituted β-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions
Nasheri, Neda, McKay, Craig S., Fulton, Kelly, Twine, Susan, Powdrill, Megan H., Sherratt, Allison R., Pezacki, John Paul
Published in Chembiochem : a European journal of chemical biology (13.10.2014)
Published in Chembiochem : a European journal of chemical biology (13.10.2014)
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Journal Article
Hepatitis C Virus Helicase Binding Activity Monitored through Site-Specific Labeling Using an Expanded Genetic Code
Ablenas, Christopher J, Gidi, Yasser, Powdrill, Megan H, Ahmed, Noreen, Shaw, Tyler A, Mesko, Mihai, Götte, Matthias, Cosa, Gonzalo, Pezacki, John Paul
Published in ACS infectious diseases (13.12.2019)
Published in ACS infectious diseases (13.12.2019)
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Synthesis and antiviral activity of 2′-deoxy-2′-fluoro-2′- C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates
Shi, Junxing, Zhou, Longhu, Zhang, Hongwang, McBrayer, Tamara R., Detorio, Mervi A., Johns, Melissa, Bassit, Leda, Powdrill, Megan H., Whitaker, Tony, Coats, Steven J., Götte, Matthias, Schinazi, Raymond F.
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Chemical Methods for Probing Virus–Host Proteomic Interactions
Strmiskova, Miroslava, Desrochers, Geneviève F, Shaw, Tyler A, Powdrill, Megan H, Lafreniere, Matthew A, Pezacki, John Paul
Published in ACS infectious diseases (11.11.2016)
Published in ACS infectious diseases (11.11.2016)
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Journal Article
Reactivity of -acyl hydrazone probes with the mammalian proteome
Shaw, Tyler A, Powdrill, Megan H, Sherratt, Allison R, Garland, Keira, Li, Bin-Jie, Beauchemin, André M, Pezacki, John Paul
Published in RSC medicinal chemistry (26.05.2021)
Published in RSC medicinal chemistry (26.05.2021)
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Journal Article
Hydrophobic Triaryl-Substituted [beta]-Lactams as Activity-Based Probes for Profiling Eukaryotic Enzymes and Host-Pathogen Interactions
Nasheri, Neda, McKay, Craig S, Fulton, Kelly, Twine, Susan, Powdrill, Megan H, Sherratt, Allison R, Pezacki, John Paul
Published in Chembiochem : a European journal of chemical biology (13.10.2014)
Published in Chembiochem : a European journal of chemical biology (13.10.2014)
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