Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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Journal Article
From benzimidazole to indole-5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase. Part 1: Indole C-2 SAR and discovery of diamide derivatives with nanomolar potency in cell-based subgenomic replicons
Beaulieu, Pierre L., Gillard, James, Jolicoeur, Eric, Duan, Jianmin, Garneau, Michel, Kukolj, George, Poupart, Marc-André
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors
Stammers, Timothy A., Coulombe, René, Rancourt, Jean, Thavonekham, Bounkham, Fazal, Gulrez, Goulet, Sylvie, Jakalian, Araz, Wernic, Dominic, Tsantrizos, Youla, Poupart, Marc-André, Bös, Michael, McKercher, Ginette, Thauvette, Louise, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization
Goulet, Sylvie, Poupart, Marc-André, Gillard, James, Poirier, Martin, Kukolj, George, Beaulieu, Pierre L.
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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Journal Article
Discovery of the First Thumb Pocket 1 NS5B Polymerase Inhibitor (BILB 1941) with Demonstrated Antiviral Activity in Patients Chronically Infected with Genotype 1 Hepatitis C Virus (HCV)
Beaulieu, Pierre L, Bös, Michael, Cordingley, Michael G, Chabot, Catherine, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Jolicoeur, Eric, LaPlante, Steven, McKercher, Ginette, Poirier, Martin, Poupart, Marc-André, Tsantrizos, Youla S, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Journal Article
Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): Central amino acid linker and right-hand-side SAR studies
Beaulieu, Pierre L., Chabot, Catherine, Duan, Jianmin, Garneau, Michel, Gillard, James, Jolicoeur, Eric, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy A., Kukolj, George, Tsantrizos, Youla S.
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
Published in Bioorganic & medicinal chemistry letters (15.06.2011)
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Journal Article
Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase — Acylsulfonamides and acylsulfamides as carboxylic acid replacements
Beaulieu, Pierre L., Coulombe, Rene, Gillard, James, Brochu, Christian, Duan, Jianmin, Garneau, Michel, Jolicoeur, Eric, Kuhn, Peter, Poupart, Marc-Andre, Rancourt, Jean, Stammers, Timothy A., Thavonekham, Bounkham, Kukolj, George
Published in Canadian journal of chemistry (01.01.2013)
Published in Canadian journal of chemistry (01.01.2013)
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Journal Article
Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor
FENWICK, Craig, AMAD, Ma'an, FADER, Lee D, FAUCHER, Anne-Marie, GARNEAU, Michel, JAKALIAN, Araz, KAWAI, Stephen, LAMORTE, Louie, LAPLANTE, Steven, LAIBIN LUO, MASON, Steve, POUPART, Marc-André, BAILEY, Murray D, RIOUX, Nathalie, SCHROEDER, Patricia, SIMONEAU, Bruno, TREMBLAY, Sonia, TSANTRIZOS, Youla, WITVROUW, Myriam, YOAKIM, Christiane, BETHELL, Richard, BÖS, Michael, BONNEAU, Pierre, CORDINGLEY, Michael, COULOMBE, René, DUAN, Jianmin, EDWARDS, Paul
Published in Antimicrobial agents and chemotherapy (01.06.2014)
Published in Antimicrobial agents and chemotherapy (01.06.2014)
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Journal Article
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor
Fandrick, Keith R., Li, Wenjie, Zhang, Yongda, Tang, Wenjun, Gao, Joe, Rodriguez, Sonia, Patel, Nitinchandra D., Reeves, Diana C., Wu, Jiang-Ping, Sanyal, Sanjit, Gonnella, Nina, Qu, Bo, Haddad, Nizar, Lorenz, Jon C., Sidhu, Kanwar, Wang, June, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Tsantrizos, Youla, Poupart, Marc-André, Busacca, Carl A., Yee, Nathan K., Lu, Bruce Z., Senanayake, Chris H.
Published in Angewandte Chemie (International ed.) (08.06.2015)
Published in Angewandte Chemie (International ed.) (08.06.2015)
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Journal Article
Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)
Llinàs-Brunet, Montse, Bailey, Murray D, Goudreau, Nathalie, Bhardwaj, Punit K, Bordeleau, Josée, Bös, Michael, Bousquet, Yves, Cordingley, Michael G, Duan, Jiamin, Forgione, Pat, Garneau, Michel, Ghiro, Elise, Gorys, Vida, Goulet, Sylvie, Halmos, Ted, Kawai, Stephen H, Naud, Julie, Poupart, Marc-André, White, Peter W
Published in Journal of medicinal chemistry (09.09.2010)
Published in Journal of medicinal chemistry (09.09.2010)
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Journal Article
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV‑1
Fader, Lee D, Malenfant, Eric, Parisien, Mathieu, Carson, Rebekah, Bilodeau, François, Landry, Serge, Pesant, Marc, Brochu, Christian, Morin, Sébastien, Chabot, Catherine, Halmos, Ted, Bousquet, Yves, Bailey, Murray D, Kawai, Stephen H, Coulombe, René, LaPlante, Steven, Jakalian, Araz, Bhardwaj, Punit K, Wernic, Dominik, Schroeder, Patricia, Amad, Ma’an, Edwards, Paul, Garneau, Michel, Duan, Jianmin, Cordingley, Michael, Bethell, Richard, Mason, Stephen W, Bös, Michael, Bonneau, Pierre, Poupart, Marc-André, Faucher, Anne-Marie, Simoneau, Bruno, Fenwick, Craig, Yoakim, Christiane, Tsantrizos, Youla
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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Journal Article
An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus
Lamarre, Daniel, Anderson, Paul C, Bailey, Murray, Beaulieu, Pierre, Bolger, Gordon, Bonneau, Pierre, Bös, Michael, Cameron, Dale R, Cartier, Mireille, Cordingley, Michael G, Faucher, Anne-Marie, Goudreau, Nathalie, Kawai, Stephen H, Kukolj, George, Lagacé, Lisette, LaPlante, Steven R, Narjes, Hans, Poupart, Marc-André, Rancourt, Jean, Sentjens, Roel E, St George, Roger, Simoneau, Bruno, Steinmann, Gerhard, Thibeault, Diane, Tsantrizos, Youla S, Weldon, Steven M, Yong, Chan-Loi, Llinàs-Brunet, Montse
Published in Nature (13.11.2003)
Published in Nature (13.11.2003)
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Journal Article
Cleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
Uhlmann, Frank, Wernic, Dominik, Poupart, Marc-André, Koonin, Eugene V, Nasmyth, Kim
Published in Cell (27.10.2000)
Published in Cell (27.10.2000)
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Journal Article
Discovery of BI 207524, an Indole Diamide NS5B Thumb Pocket 1 Inhibitor with Improved Potency for the Potential Treatment of Chronic Hepatitis C Virus Infection
Beaulieu, Pierre L, Anderson, Paul C, Bethell, Richard, Bös, Michael, Bousquet, Yves, Brochu, Christian, Cordingley, Michael G, Fazal, Gulrez, Garneau, Michel, Gillard, James R, Kawai, Stephen, Marquis, Martin, McKercher, Ginette, Poupart, Marc-André, Stammers, Timothy, Thavonekham, Bounkham, Wernic, Dominik, Duan, Jianmin, Kukolj, George
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase
Kukolj, George, McGibbon, Graham A., McKercher, Ginette, Marquis, Martin, Lefèbvre, Sylvain, Thauvette, Louise, Gauthier, Jean, Goulet, Sylvie, Poupart, Marc-André, Beaulieu, Pierre L.
Published in The Journal of biological chemistry (25.11.2005)
Published in The Journal of biological chemistry (25.11.2005)
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Journal Article
Phosphorylation of the Cohesin Subunit Scc1 by Polo/Cdc5 Kinase Regulates Sister Chromatid Separation in Yeast
Alexandru, Gabriela, Uhlmann, Frank, Mechtler, Karl, Poupart, Marc-André, Nasmyth, Kim
Published in Cell (18.05.2001)
Published in Cell (18.05.2001)
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Journal Article
N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies
Beaulieu, Pierre L., Jolicoeur, Eric, Gillard, James, Brochu, Christian, Coulombe, René, Dansereau, Nathalie, Duan, Jianmin, Garneau, Michel, Jakalian, Araz, Kühn, Peter, Lagacé, Lisette, LaPlante, Steven, McKercher, Ginette, Perrault, Stéphane, Poirier, Martin, Poupart, Marc-André, Stammers, Timothy, Thauvette, Louise, Thavonekham, Bounkham, Kukolj, George
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Studies directed toward the total synthesis of cerorubenic acid-III. 3. A convergent enantioselective approach involving new arrangements for the actuation of ring D cyclization
Paquette, Leo A, Deaton, David N, Endo, Yasuyuki, Poupart, Marc Andre
Published in Journal of organic chemistry (01.07.1993)
Published in Journal of organic chemistry (01.07.1993)
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Journal Article
Concise and Practical Asymmetric Synthesis of a Challenging Atropisomeric HIV Integrase Inhibitor
Fandrick, Keith R., Li, Wenjie, Zhang, Yongda, Tang, Wenjun, Gao, Joe, Rodriguez, Sonia, Patel, Nitinchandra D., Reeves, Diana C., Wu, Jiang-Ping, Sanyal, Sanjit, Gonnella, Nina, Qu, Bo, Haddad, Nizar, Lorenz, Jon C., Sidhu, Kanwar, Wang, June, Ma, Shengli, Grinberg, Nelu, Lee, Heewon, Tsantrizos, Youla, Poupart, Marc-André, Busacca, Carl A., Yee, Nathan K., Lu, Bruce Z., Senanayake, Chris H.
Published in Angewandte Chemie (08.06.2015)
Published in Angewandte Chemie (08.06.2015)
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Journal Article
α4β7 인테그린을 표적으로 하는 고리형 펩타이드
ROUGHTON ANDREW L, POUPART MARC ANDRE, VAZQUEZ MANUEL PEREZ, YANG GAOQIANG, GILLARD JAMES, MORSHED M. MONZUR, HICKEY JENNIFER L, KAFAL ADAM PAUL, PATEL NARENDRA, CHAKKA SAI KUMAR
Year of Publication 28.08.2018
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Year of Publication 28.08.2018
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