Loading…
Potent reduction of plasma lipoprotein (a) with an antisense oligonucleotide in human subjects does not affect ex vivo fibrinolysis
Boffa, Michael B., Marar, Tanya T., Yeang, Calvin, Viney, Nicholas J., Xia, Shuting, Witztum, Joseph L., Koschinsky, Marlys L., Tsimikas, Sotirios
Published in Journal of lipid research (01.12.2019)
Published in Journal of lipid research (01.12.2019)
Get full text
Journal Article
Loading…
A potent hepatitis B surface antigen response in subjects with inactive hepatitis B surface antigen carrier treated with pegylated‐interferon alpha
Cao, Zhenhuan, Liu, Yali, Ma, Lina, Lu, Junfeng, Jin, Yi, Ren, Shan, He, Zhimin, Shen, Chengli, Chen, Xinyue
Published in Hepatology (Baltimore, Md.) (01.10.2017)
Published in Hepatology (Baltimore, Md.) (01.10.2017)
Get full text
Journal Article
Loading…
Endothelial Function in Human Immunodeficiency Virus-Infected Antiretroviral-Naive Subjects Before and After Starting Potent Antiretroviral Therapy : The ACTG (AIDS Clinical Trials Group) Study 5152s
TORRIANI, Francesca J, KOMAROW, Lauren, SQUIRES, Kathleen, STEIN, James H, PARKER, Robert A, COTTER, Bruno R, CURRIER, Judith S, DUBE, Michael P, FICHTENBAUM, Carl J, GERSCHENSON, Mariana, MITCHELL, Carol K. C, MURPHY, Robert L
Published in Journal of the American College of Cardiology (12.08.2008)
Published in Journal of the American College of Cardiology (12.08.2008)
Get full text
Journal Article
Loading…
Mass balance, metabolic disposition, and pharmacokinetics of [14C]ensartinib, a novel potent anaplastic lymphoma kinase (ALK) inhibitor, in healthy subjects following oral administration
Zhou, Sufeng, Liu, Wei, Zhou, Chen, Zhang, Lingling, Xie, Lijun, Xu, Zhaoqiang, Wang, Lu, Zhao, Yuqing, Guo, Lian, Chen, Juan, Ding, Lieming, Mao, Li, Tao, Yi, Zhang, Chen, Ding, Sijia, Shao, Feng
Published in Cancer chemotherapy and pharmacology (01.12.2020)
Published in Cancer chemotherapy and pharmacology (01.12.2020)
Get full text
Journal Article
Loading…
Loading…
Safety, pharmacokinetics and pharmacodynamics of GLPG0974, a potent and selective FFA2 antagonist, in healthy male subjects
Namour, Florence, Galien, René, Van Kaem, Tim, Van der Aa, Annegret, Vanhoutte, Frédéric, Beetens, Johan, Klooster, Gerben
Published in British journal of clinical pharmacology (01.07.2016)
Published in British journal of clinical pharmacology (01.07.2016)
Get full text
Journal Article
Loading…
Evaluation of drug–drug interactions of a novel potent FLT3 inhibitor SKLB1028 in healthy subjects
Chen, Jingcheng, Wu, Jingxuan, Guo, Nini, Song, Yuqin, Li, Lijun, Wang, Bingyan, Li, Jiangshuo, Hou, Mengyu, Yin, Hang, Zhang, Meijuan, Kong, Yanhong, Wu, Xiaofang, Li, Ran, Wu, Le, Gao, Qiannan, Dong, Ruihua
Published in Clinical and translational science (01.11.2024)
Published in Clinical and translational science (01.11.2024)
Get full text
Journal Article
Loading…
Potent Antibody Response Elicited by a Third Booster Dose of Inactivated COVID-19 Vaccine in Healthy Subjects
Ji, Ruili, Zhang, Jiaqi, Liang, Dan, Quan, Hongbing, Wu, Yue, Peng, Aiping, Li, Weili, Lu, Shaofang, Zhang, Xuedong, Ke, Changwen, Wang, Dawei, Xu, Jianhua
Published in Viral immunology (01.11.2023)
Published in Viral immunology (01.11.2023)
Get more information
Journal Article
Loading…
Loading…
Loading…
Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ Failure
Uckun, Fatih M., Carlson, James, Orhan, Cemal, Powell, Joy, Pizzimenti, Natalie M., van Wyk, Hendrik, Ozercan, Ibrahim H., Volk, Michael, Sahin, Kazim
Published in Frontiers in pharmacology (10.11.2020)
Published in Frontiers in pharmacology (10.11.2020)
Get full text
Journal Article
Loading…
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects
Tran, Phi, Hanna, Imad, Eggimann, Fabian Kurt, Schoepfer, Joseph, Ray, Tapan, Zhu, Bing, Wang, Lai, Priess, Petra, Tian, Xianbin, Hourcade-Potelleret, Florence, Einolf, Heidi J.
Published in Xenobiotica (01.02.2020)
Published in Xenobiotica (01.02.2020)
Get full text
Journal Article
Loading…
Microparticles Produced by Activated Platelets Carry a Potent and Functionally Active Angiogenic Signal in Subjects with Crohn’s Disease
Gaetani, Eleonora, Del Zompo, Fabio, Marcantoni, Margherita, Gatto, Ilaria, Giarretta, Igor, Porfidia, Angelo, Scaldaferri, Franco, Laterza, Lucrezia, Lopetuso, Loris, Gasbarrini, Antonio, Pola, Roberto
Published in International journal of molecular sciences (26.09.2018)
Published in International journal of molecular sciences (26.09.2018)
Get full text
Journal Article
Loading…
Empagliflozin (BI 10773), a Potent and Selective SGLT2 Inhibitor, Induces Dose-Dependent Glucosuria in Healthy Subjects
Seman, Leo, Macha, Sreeraj, Nehmiz, Gerhard, Simons, Gudrun, Ren, Bailuo, Pinnetti, Sabine, Woerle, Hans J, Dugi, Klaus
Published in Clinical pharmacology in drug development (01.04.2013)
Published in Clinical pharmacology in drug development (01.04.2013)
Get more information
Journal Article
Loading…
Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis
Barth, P., Bruijnzeel, P., Wach, A., Sellier Kessler, O., Hooftman, L., Zimmermann, J., Naue, N., Huber, B., Heimbeck, I., Kappeler, D., Timmer, W., Chevalier, E.
Published in Journal of cystic fibrosis (01.03.2020)
Published in Journal of cystic fibrosis (01.03.2020)
Get full text
Journal Article
Loading…
WED-361 Dosing with the Capsid Assembly Modulator ALG-000184 in Untreated HBeAg Negative CHB Subjects Results in Potent Antiviral Effects Including Suppression of HBV DNA/RNA and Declines in HBcrAg Levels
Agarwal, Kosh, Gane, Edward J., Yuen, Man-Fung, Schwabe, Christian, Jucov, Alina, Haceatrean, Alexei, Wu, Min, Le, Kha, Maderazo, Maida, Blatt, Lawrence, Chanda, Sushmita, Lin, Tse-I, McClure, Matt
Published in Journal of hepatology (01.06.2024)
Published in Journal of hepatology (01.06.2024)
Get full text
Journal Article
Loading…
Multiple-dose pharmacodynamics and pharmacokinetics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects
Krishna, R, Bergman, A J, Jin, B, Fallon, M, Cote, J, Van Hoydonck, P, Laethem, T, Gendrano, 3rd, I N, Van Dyck, K, Hilliard, D, Laterza, O, Snyder, K, Chavez-Eng, C, Lutz, R, Chen, J, Bloomfield, D M, De Smet, M, Van Bortel, L M, Gutierrez, M, Al-Huniti, N, Dykstra, K, Gottesdiener, K M, Wagner, J A
Published in Clinical pharmacology and therapeutics (01.12.2008)
Published in Clinical pharmacology and therapeutics (01.12.2008)
Get more information
Journal Article
Loading…
The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells
Weng, Zuyi, Patel, Arti B., Panagiotidou, Smaro, Theoharides, Theoharis C.
Published in Journal of allergy and clinical immunology (01.04.2015)
Published in Journal of allergy and clinical immunology (01.04.2015)
Get full text
Journal Article
Loading…
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Chen, Qian, Wu, Qingqing, Song, Rong, Wang, Yating, Zhang, Mengqi, Li, Fangqiong, Zeng, Weifang, Wang, Wei, Jia, Jingying, Yu, Chen, Liu, Yanmei
Published in Frontiers in pharmacology (11.12.2023)
Published in Frontiers in pharmacology (11.12.2023)
Get full text
Journal Article
Loading…
Clinical Pharmacology of the Reversible and Potent P2Y 12 Receptor Antagonist ACT-246475 After Single Subcutaneous Administration in Healthy Male Subjects
Juif, Pierre-Eric, Boehler, Margaux, Dobrow, Michael, Ufer, Mike, Dingemanse, Jasper
Published in Journal of clinical pharmacology (01.01.2019)
Published in Journal of clinical pharmacology (01.01.2019)
Get more information
Journal Article