Inhibition of Inflammatory and Neuropathic Pain by Targeting a Mu Opioid Receptor/Chemokine Receptor5 Heteromer (MOR-CCR5)
Akgün, Eyup, Javed, Muhammad I, Lunzer, Mary M, Powers, Michael D, Sham, Yuk Y, Watanabe, Yoshikazu, Portoghese, Philip S
Published in Journal of medicinal chemistry (12.11.2015)
Published in Journal of medicinal chemistry (12.11.2015)
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Journal Article
Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception
Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Smeester, Branden A., Beitz, Al J., Portoghese, Philip S.
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (09.07.2013)
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Journal Article
A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance
Dutta, Raini, Lunzer, Mary M, Auger, Jennifer L, Akgün, Eyup, Portoghese, Philip S, Binstadt, Bryce A
Published in Arthritis research & therapy (27.07.2018)
Published in Arthritis research & therapy (27.07.2018)
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Journal Article
Opioid-Induced Tolerance and Dependence in Mice Is Modulated by the Distance between Pharmacophores in a Bivalent Ligand Series
David J. Daniels, Natalie R. Lenard, Chris L. Etienne, Law, Ping-Yee, Sandra C. Roerig, Portoghese, Philip S.
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (27.12.2005)
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Journal Article
Heteromer Induction: An Approach to Unique Pharmacology?
Portoghese, Philip S, Akgün, Eyup, Lunzer, Mary M
Published in ACS chemical neuroscience (15.03.2017)
Published in ACS chemical neuroscience (15.03.2017)
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Journal Article
Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model
Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
Published in European journal of pharmacology (15.11.2014)
Published in European journal of pharmacology (15.11.2014)
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Journal Article
Putative Kappa Opioid Heteromers As Targets for Developing Analgesics Free of Adverse Effects
Le Naour, Morgan, Lunzer, Mary M, Powers, Michael D, Kalyuzhny, Alexander E, Benneyworth, Michael A, Thomas, Mark J, Portoghese, Philip S
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
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Journal Article
A Heterodimer-Selective Agonist Shows in vivo Relevance of G Protein-Coupled Receptor Dimers
Waldhoer, Maria, Fong, Jamie, Jones, Robert M., Lunzer, Mary M., Sharma, Shiv K., Kostenis, Evi, Portoghese, Philip S., Whistler, Jennifer L., Lifton, Richard P.
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (21.06.2005)
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Journal Article
N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers
Yekkirala, Ajay S, Lunzer, Mary M, McCurdy, Christopher R, Powers, Michael D, Kalyuzhny, Alexander E, Roerig, Sandra C, Portoghese, Philip S
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (22.03.2011)
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Journal Article
In Memory of Professor Hualiang Jiang
Ding, Ke, Wang, Shaomeng, Georg, Gunda I., Portoghese, Philip S., Lindsley, Craig W.
Published in Journal of medicinal chemistry (14.09.2023)
Published in Journal of medicinal chemistry (14.09.2023)
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Journal Article
The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients
Adams, Timothy B, Cohen, Samuel M, Doull, John, Feron, Victor J, Goodman, Jay I, Marnett, Lawrence J, Munro, Ian C, Portoghese, Philip S, Smith, Robert L, Waddell, William J, Wagner, Bernard M
Published in Food and Chemical Toxicology (01.02.2004)
Published in Food and Chemical Toxicology (01.02.2004)
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Book Review
Journal Article
MMG22 Potently Blocks Hyperalgesia in Cisplatin-treated Mice
Cataldo, Giuseppe, Lunzer, Mary M., Akgün, Eyup, Wong, Henry L., Portoghese, Philip S., Simone, Donald A.
Published in Neuroscience (15.04.2023)
Published in Neuroscience (15.04.2023)
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Journal Article
FBNTI, a DOR-Selective Antagonist That Allosterically Activates MOR within a MOR–DOR Heteromer
Akgün, Eyup, Lunzer, Mary M, Tian, Defeng, Ansonoff, Michael, Pintar, John, Bruce, Daniel, Hawkinson, Jon E, Wilcox, George L, Portoghese, Philip S
Published in Biochemistry (Easton) (11.05.2021)
Published in Biochemistry (Easton) (11.05.2021)
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Journal Article
The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward
Cataldo, Giuseppe, Erb, Samuel J., Lunzer, Mary M., Luong, Nhungoc, Akgün, Eyup, Portoghese, Philip S., Olson, Julie K., Simone, Donald A.
Published in Neuropharmacology (01.11.2019)
Published in Neuropharmacology (01.11.2019)
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Journal Article
Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5
Shueb, Sarah S., Erb, Samuel J., Lunzer, Mary M., Speltz, Rebecca, Harding-Rose, Catherine, Akgün, Eyup, Simone, Donald A., Portoghese, Philip S.
Published in Neuropharmacology (01.12.2019)
Published in Neuropharmacology (01.12.2019)
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Journal Article
Bivalent Ligands That Target μ Opioid (MOP) and Cannabinoid1 (CB1) Receptors Are Potent Analgesics Devoid of Tolerance
Le Naour, Morgan, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M, Powers, Mike D, Kalyuzhny, Alexander E, Portoghese, Philip S
Published in Journal of medicinal chemistry (11.07.2013)
Published in Journal of medicinal chemistry (11.07.2013)
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Journal Article
The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids
Speltz, Rebecca, Lunzer, Mary M, Shueb, Sarah S, Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S, Simone, Donald A
Published in Pain (Amsterdam) (01.09.2020)
Published in Pain (Amsterdam) (01.09.2020)
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Journal Article