Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo
Porta, Sílvia, Xu, Yan, Restrepo, Clark R., Kwong, Linda K., Zhang, Bin, Brown, Hannah J., Lee, Edward B., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Nature communications (11.10.2018)
Published in Nature communications (11.10.2018)
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MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
Miñones-Moyano, Elena, Porta, Sílvia, Escaramís, Georgia, Rabionet, Raquel, Iraola, Susana, Kagerbauer, Birgit, Espinosa-Parrilla, Yolanda, Ferrer, Isidre, Estivill, Xavier, Martí, Eulàlia
Published in Human molecular genetics (01.08.2011)
Published in Human molecular genetics (01.08.2011)
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Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
Darwich, Nabil F, Phan, Jessica M, Kim, Boram, Suh, EunRan, Papatriantafyllou, John D, Changolkar, Lakshmi, Nguyen, Aivi T, O'Rourke, Caroline M, He, Zhuohao, Porta, Sílvia, Gibbons, Garrett S, Luk, Kelvin C, Papageorgiou, Sokratis G, Grossman, Murray, Massimo, Lauren, Irwin, David J, McMillan, Corey T, Nasrallah, Ilya M, Toro, Camilo, Aguirre, Geoffrey K, Van Deerlin, Vivianna M, Lee, Edward B
Published in Science (American Association for the Advancement of Science) (20.11.2020)
Published in Science (American Association for the Advancement of Science) (20.11.2020)
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Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease
Uemura, Maiko T., Robinson, John L., Cousins, Katheryn A. Q., Tropea, Thomas F., Kargilis, Daniel C., McBride, Jennifer D., Suh, EunRan, Xie, Sharon X., Xu, Yan, Porta, Sílvia, Uemura, Norihito, Van Deerlin, Vivianna M., Wolk, David A., Irwin, David J., Brunden, Kurt R., Lee, Virginia M.-Y., Lee, Edward B., Trojanowski, John Q.
Published in Acta neuropathologica (01.01.2022)
Published in Acta neuropathologica (01.01.2022)
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Journal Article
Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration
Robinson, John L, Porta, Sílvia, Garrett, Filip G, Zhang, Panpan, Xie, Sharon X, Suh, EunRan, Van Deerlin, Vivianna M, Abner, Erin L, Jicha, Gregory A, Barber, Justin M, Lee, Virginia M-Y, Lee, Edward B, Trojanowski, John Q, Nelson, Peter T
Published in Brain (London, England : 1878) (01.09.2020)
Published in Brain (London, England : 1878) (01.09.2020)
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ECLiPSE: a versatile classification technique for structural and morphological analysis of 2D and 3D single-molecule localization microscopy data
Hugelier, Siewert, Tang, Qing, Kim, Hannah Hyun-Sook, Gyparaki, Melina Theoni, Bond, Charles, Santiago-Ruiz, Adriana Naomi, Porta, Sílvia, Lakadamyali, Melike
Published in Nature methods (01.10.2024)
Published in Nature methods (01.10.2024)
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Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration
Lee, Edward B., Porta, Sílvia, Michael Baer, G., Xu, Yan, Suh, EunRan, Kwong, Linda K., Elman, Lauren, Grossman, Murray, Lee, Virginia M.-Y., Irwin, David J., Van Deerlin, Vivianna M., Trojanowski, John Q.
Published in Acta neuropathologica (01.07.2017)
Published in Acta neuropathologica (01.07.2017)
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Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo
Porta, Sílvia, Xu, Yan, Lehr, Tagan, Zhang, Bin, Meymand, Emily, Olufemi, Modupe, Stieber, Anna, Lee, Edward B., Trojanowski, John Q., Lee, Virginia M.‐Y.
Published in Neuropathology and applied neurobiology (01.12.2021)
Published in Neuropathology and applied neurobiology (01.12.2021)
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Journal Article
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD
Afroz, Tariq, Chevalier, Elodie, Audrain, Mickael, Dumayne, Christopher, Ziehm, Tamar, Moser, Roger, Egesipe, Anne-Laure, Mottier, Lorène, Ratnam, Monisha, Neumann, Manuela, Havas, Daniel, Ollier, Romain, Piorkowska, Kasia, Chauhan, Mayank, Silva, Alberto B., Thapa, Samjhana, Stöhr, Jan, Bavdek, Andrej, Eligert, Valerie, Adolfsson, Oskar, Nelson, Peter T., Porta, Sílvia, Lee, Virginia M.-Y., Pfeifer, Andrea, Kosco-Vilbois, Marie, Seredenina, Tamara
Published in Neurobiology of disease (01.04.2023)
Published in Neurobiology of disease (01.04.2023)
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Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage
Kumar, Senthil T., Nazarov, Sergey, Porta, Sílvia, Maharjan, Niran, Cendrowska, Urszula, Kabani, Malek, Finamore, Francesco, Xu, Yan, Lee, Virginia M.-Y., Lashuel, Hilal A.
Published in Nature neuroscience (01.06.2023)
Published in Nature neuroscience (01.06.2023)
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TMEM106B modifies TDP-43 pathology in human ALS brain and cell-based models of TDP-43 proteinopathy
Mao, Fei, Robinson, John L., Unger, Travis, Posavi, Marijan, Amado, Defne A., Elman, Lauren, Grossman, Murray, Wolk, David A., Lee, Edward B., Van Deerlin, Vivianna M., Porta, Sílvia, Lee, Virginia M. Y., Trojanowski, John Q., Chen-Plotkin, Alice S.
Published in Acta neuropathologica (01.10.2021)
Published in Acta neuropathologica (01.10.2021)
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Journal Article
Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
Chung, Chia-Yu, Berson, Amit, Kennerdell, Jason R., Sartoris, Ashley, Unger, Travis, Porta, Sílvia, Kim, Hyung-Jun, Smith, Edwin R., Shilatifard, Ali, Van Deerlin, Vivianna, Lee, Virginia M.-Y., Chen-Plotkin, Alice, Bonini, Nancy M.
Published in Nature communications (23.10.2018)
Published in Nature communications (23.10.2018)
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Journal Article
myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
Martí, Eulàlia, Pantano, Lorena, Bañez-Coronel, Mónica, Llorens, Franc, Miñones-Moyano, Elena, Porta, Sílvia, Sumoy, Lauro, Ferrer, Isidre, Estivill, Xavier
Published in Nucleic acids research (01.11.2010)
Published in Nucleic acids research (01.11.2010)
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Journal Article
TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling
Berson, Amit, Sartoris, Ashley, Nativio, Raffaella, Van Deerlin, Vivianna, Toledo, Jon B., Porta, Sílvia, Liu, Shichong, Chung, Chia-Yu, Garcia, Benjamin A., Lee, Virginia M.-Y., Trojanowski, John Q., Johnson, F. Brad, Berger, Shelley L., Bonini, Nancy M.
Published in Current biology (04.12.2017)
Published in Current biology (04.12.2017)
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Annexin A11 aggregation in FTLD–TDP type C and related neurodegenerative disease proteinopathies
Robinson, John L., Suh, EunRan, Xu, Yan, Hurtig, Howard I., Elman, Lauren, McMillan, Corey T., Irwin, David J., Porta, Sílvia, Van Deerlin, Vivianna M., Lee, Edward B.
Published in Acta neuropathologica (01.06.2024)
Published in Acta neuropathologica (01.06.2024)
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Increased striatal adenosine A2A receptor levels is an early event in Parkinson’s disease-related pathology and it is potentially regulated by miR-34b
Villar-Menéndez, Izaskun, Porta, Sílvia, Buira, Sandra P, Pereira-Veiga, Thais, Díaz-Sánchez, Sara, Albasanz, José Luis, Ferrer, Isidre, Martín, Mairena, Barrachina, Marta
Published in Neurobiology of disease (01.09.2014)
Published in Neurobiology of disease (01.09.2014)
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Association of quantitative histopathology measurements with antemortem medial temporal lobe cortical thickness in the Alzheimer’s disease continuum
Denning, Amanda E., Ittyerah, Ranjit, Levorse, Lisa M., Sadeghpour, Niyousha, Athalye, Chinmayee, Chung, Eunice, Ravikumar, Sadhana, Dong, Mengjin, Duong, Michael Tran, Li, Yue, Ilesanmi, Ademola, Sreepada, Lasya P., Sabatini, Philip, Lowe, MaKayla, Bahena, Alejandra, Zablah, Jamila, Spencer, Barbara E., Watanabe, Ryohei, Kim, Boram, Sørensen, Maja Højvang, Khandelwal, Pulkit, Brown, Christopher, Hrybouski, Stanislau, Xie, Sharon X., de Flores, Robin, Robinson, John L., Schuck, Theresa, Ohm, Daniel T., Arezoumandan, Sanaz, Porta, Sílvia, Detre, John A., Insausti, Ricardo, Wisse, Laura E. M., Das, Sandhitsu R., Irwin, David J., Lee, Edward B., Wolk, David A., Yushkevich, Paul A.
Published in Acta neuropathologica (03.09.2024)
Published in Acta neuropathologica (03.09.2024)
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Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory
MARTIN, Katherine R, CORLETT, Alicia, FINKELSTEIN, David I, PRITCHARD, Melanie A, DUBACH, Daphne, MUSTAFA, Tomris, COLEMAN, Harold A, PARKINGTON, Helena C, MERSON, Tobias D, BOURNE, James A, PORTA, Sílvia, ARBONES, Maria L
Published in Human molecular genetics (01.07.2012)
Published in Human molecular genetics (01.07.2012)
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Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
Chung, Chia-Yu, Berson, Amit, Kennerdell, Jason R., Sartoris, Ashley, Unger, Travis, Porta, Sílvia, Kim, Hyung-Jun, Smith, Edwin R., Shilatifard, Ali, Van Deerlin, Vivianna, Lee, Virginia M. -Y., Chen-Plotkin, Alice, Bonini, Nancy M.
Published in Nature communications (29.01.2019)
Published in Nature communications (29.01.2019)
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Journal Article
Drosha Inclusions Are New Components of Dipeptide-Repeat Protein Aggregates in FTLD-TDP and ALS C9orf72 Expansion Cases
Porta, Sílvia, Kwong, Linda K., Trojanowski, John Q., Lee, Virginia M.-Y.
Published in Journal of neuropathology and experimental neurology (01.04.2015)
Published in Journal of neuropathology and experimental neurology (01.04.2015)
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